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Glaucoma and the applications of carbonic anhydrase inhibitors.
Scozzafava A, Supuran CT. Scozzafava A, et al. Subcell Biochem. 2014;75:349-59. doi: 10.1007/978-94-007-7359-2_17. Subcell Biochem. 2014. PMID: 24146387 Review.
Inhibition of carbonic anhydrase (CA, EC 4.2.1.1) has pharmacologic applications in the treatment of glaucoma, a disease affecting a large number of people and characterized by an elevated intraocular pressure (IOP). ...
Inhibition of carbonic anhydrase (CA, EC 4.2.1.1) has pharmacologic applications in the treatment of glaucoma, a disease affecting …
Carbonic Anhydrase Inhibitors Part 72 Synthesis and Antiglaucoma Properties of Metal Complexes of p-Fluorobenzolamide.
Supuran CT, Scozzafava A, Menabuoni L, Mincione F, Briganti F, Mincione G. Supuran CT, et al. Among authors: scozzafava a. Met Based Drugs. 1999;6(2):67-73. doi: 10.1155/MBD.1999.67. Met Based Drugs. 1999. PMID: 18475883 Free PMC article.
Metal complexes of a heterocyclic sulfonamides possessing very strong carbonic anhydrase (CA) inhibitory properties, i.e., 5-(p-fluorobenzenesulfonylamido)-1,3,4-thiadiazole-2-sulfonamide (p-fluorobenzolamide) were prepared. ...Some of these new complexes as well as the pa …
Metal complexes of a heterocyclic sulfonamides possessing very strong carbonic anhydrase (CA) inhibitory properties, i.e., 5-(p-fluor …
Carbonic Anhydrase Inhibitors. Part 55 Metal Complexes of 1,3,4-Thiadiazole-2-Sulfonamide Derivatives: In Vitro Inhibition Studies With Carbonic Anhydrase Isozymes I, II and IV.
Supuran CT, Scozzafava A, Briganti F, Ilies MA, Jitianu A. Supuran CT, et al. Among authors: scozzafava a. Met Based Drugs. 1998;5(2):103-14. doi: 10.1155/MBD.1998.103. Met Based Drugs. 1998. PMID: 18475829 Free PMC article.
Complexes with biologically active ligands. Part 11. Synthesis and carbonic anhydrase inhibitory activity of metal complexes of 4,5-disubstituted-3-mercapto-1,2,4-triazole derivatives.
Scozzafava A, Cavazza C, Supuran CT, Saramet I, Briganti F, Banciu MD. Scozzafava A, et al. Met Based Drugs. 1998;5(1):11-8. doi: 10.1155/MBD.1998.11. Met Based Drugs. 1998. PMID: 18475819 Free PMC article.
Carbonic Anhydrase Activators. Part 19 Spectroscopic and Kinetic Investigations for the Interaction of Isozymes I and II With Primary Amines.
Briganti F, Scozzafava A, Supuran CT. Briganti F, et al. Among authors: scozzafava a. Met Based Drugs. 1997;4(4):221-7. doi: 10.1155/MBD.1997.221. Met Based Drugs. 1997. PMID: 18475791 Free PMC article.
This is a direct spectroscopic evidence that the activator molecules bind within the active site, but not directly to the metal ion. ...
This is a direct spectroscopic evidence that the activator molecules bind within the active site, but not directly to the metal ion. …
Carbonic anhydrase activation enhances object recognition memory in mice through phosphorylation of the extracellular signal-regulated kinase in the cortex and the hippocampus.
Canto de Souza L, Provensi G, Vullo D, Carta F, Scozzafava A, Costa A, Schmidt SD, Passani MB, Supuran CT, Blandina P. Canto de Souza L, et al. Among authors: scozzafava a. Neuropharmacology. 2017 May 15;118:148-156. doi: 10.1016/j.neuropharm.2017.03.009. Epub 2017 Mar 9. Neuropharmacology. 2017. PMID: 28286213
Rats injected with by d-phenylalanine, a carbonic anhydrase (CA) activator, enhanced spatial learning, whereas rats given acetazolamide, a CA inhibitor, exhibited impairments of fear memory consolidation. ...We investigated if CAs are involved in a non-spatia …
Rats injected with by d-phenylalanine, a carbonic anhydrase (CA) activator, enhanced spatial learning, whereas rats given acetazolami …
Anion inhibition studies of two α-carbonic anhydrases from Lotus japonicus, LjCAA1 and LjCAA2.
Vullo D, Flemetakis E, Scozzafava A, Capasso C, Supuran CT. Vullo D, et al. Among authors: scozzafava a. J Inorg Biochem. 2014 Jul;136:67-72. doi: 10.1016/j.jinorgbio.2014.03.014. Epub 2014 Apr 8. J Inorg Biochem. 2014. PMID: 24769135
LjCAA1 showed a high catalytic activity for the CO2 hydration reaction, with a k(cat) of 7.4∗10(5) s(-1) and a k(cat)/K(m) of 9.6∗10(7) M(-1) s(-1) and was inhibited in the low micromolar range by N,N-diethyldithiocarbamate, sulfamide, sulfamic acid, phenylbo …
LjCAA1 showed a high catalytic activity for the CO2 hydration reaction, with a k(cat) of 7.4∗10(5) s(-1) and a k(cat)/K …
X-ray structure of the first `extremo-α-carbonic anhydrase', a dimeric enzyme from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1.
Di Fiore A, Capasso C, De Luca V, Monti SM, Carginale V, Supuran CT, Scozzafava A, Pedone C, Rossi M, De Simone G. Di Fiore A, et al. Among authors: scozzafava a. Acta Crystallogr D Biol Crystallogr. 2013 Jun;69(Pt 6):1150-9. doi: 10.1107/S0907444913007208. Epub 2013 May 16. Acta Crystallogr D Biol Crystallogr. 2013. PMID: 23695259
SspCA, a novel `extremo-α-carbonic anhydrase' isolated from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1, is an efficient catalyst for the hydration of CO2 and presents exceptional thermostability. ...These findings are of extreme importance, sinc …
SspCA, a novel `extremo-α-carbonic anhydrase' isolated from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1, i …
7-Substituted-sulfocoumarins are isoform-selective, potent carbonic anhydrase II inhibitors.
Tanc M, Carta F, Bozdag M, Scozzafava A, Supuran CT. Tanc M, et al. Among authors: scozzafava a. Bioorg Med Chem. 2013 Aug 1;21(15):4502-10. doi: 10.1016/j.bmc.2013.05.032. Epub 2013 May 31. Bioorg Med Chem. 2013. PMID: 23769167
A series of 7-substituted sulfocoumarins and 3,4-dihydrosulfocoumarins was obtained by cyclization of the methanesulfonate of 2,4-dihydroxy- or 2-hydroxy-4-methoxybenzaldehyde, followed by derivatization reactions. The new compounds incorporate a range of substituen
A series of 7-substituted sulfocoumarins and 3,4-dihydrosulfocoumarins was obtained by cyclization of the methanesulfonate of 2,4-dih
Peptidomimetics as protein arginine deiminase 4 (PAD4) inhibitors.
Trabocchi A, Pala N, Krimmelbein I, Menchi G, Guarna A, Sechi M, Dreker T, Scozzafava A, Supuran CT, Carta F. Trabocchi A, et al. Among authors: scozzafava a. J Enzyme Inhib Med Chem. 2015 Jun;30(3):466-71. doi: 10.3109/14756366.2014.947976. Epub 2014 Sep 8. J Enzyme Inhib Med Chem. 2015. PMID: 25198885
The protein arginine deiminase 4 (PAD4) is a calcium-dependent enzyme, which catalyses the irreversible conversion of peptidyl-arginines into peptidyl-citrullines and plays an important role in several diseases such as in the rheumatoid arthritis, multiple sclerosis, Alzhe …
The protein arginine deiminase 4 (PAD4) is a calcium-dependent enzyme, which catalyses the irreversible conversion of peptidyl-argini …
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