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Evidence for GABA-A receptor dysregulation in gambling disorder: correlation with impulsivity.
Mick I, Ramos AC, Myers J, Stokes PR, Chandrasekera S, Erritzoe D, Mendez MA, Gunn RN, Rabiner EA, Searle GE, Galduróz JCF, Waldman AD, Bowden-Jones H, Clark L, Nutt DJ, Lingford-Hughes AR. Mick I, et al. Among authors: searle ge. Addict Biol. 2017 Nov;22(6):1601-1609. doi: 10.1111/adb.12457. Epub 2016 Oct 13. Addict Biol. 2017. PMID: 27739164 Free PMC article.
Positron emission tomography imaging of amphetamine-induced dopamine release in the human cortex: a comparative evaluation of the high affinity dopamine D2/3 radiotracers [11C]FLB 457 and [11C]fallypride.
Narendran R, Frankle WG, Mason NS, Rabiner EA, Gunn RN, Searle GE, Vora S, Litschge M, Kendro S, Cooper TB, Mathis CA, Laruelle M. Narendran R, et al. Among authors: searle ge. Synapse. 2009 Jun;63(6):447-61. doi: 10.1002/syn.20628. Synapse. 2009. PMID: 19217025
A multi-center randomized proof-of-concept clinical trial applying [¹⁸F]FDG-PET for evaluation of metabolic therapy with rosiglitazone XR in mild to moderate Alzheimer's disease.
Tzimopoulou S, Cunningham VJ, Nichols TE, Searle G, Bird NP, Mistry P, Dixon IJ, Hallett WA, Whitcher B, Brown AP, Zvartau-Hind M, Lotay N, Lai RY, Castiglia M, Jeter B, Matthews JC, Chen K, Bandy D, Reiman EM, Gold M, Rabiner EA, Matthews PM. Tzimopoulou S, et al. J Alzheimers Dis. 2010;22(4):1241-56. doi: 10.3233/JAD-2010-100939. J Alzheimers Dis. 2010. PMID: 20930300 Clinical Trial.
Prediction of repeat-dose occupancy from single-dose data: characterisation of the relationship between plasma pharmacokinetics and brain target occupancy.
Abanades S, van der Aart J, Barletta JA, Marzano C, Searle GE, Salinas CA, Ahmad JJ, Reiley RR, Pampols-Maso S, Zamuner S, Cunningham VJ, Rabiner EA, Laruelle MA, Gunn RN. Abanades S, et al. Among authors: searle ge. J Cereb Blood Flow Metab. 2011 Mar;31(3):944-52. doi: 10.1038/jcbfm.2010.175. Epub 2010 Oct 13. J Cereb Blood Flow Metab. 2011. PMID: 20940733 Free PMC article.
Pharmacological differentiation of opioid receptor antagonists by molecular and functional imaging of target occupancy and food reward-related brain activation in humans.
Rabiner EA, Beaver J, Makwana A, Searle G, Long C, Nathan PJ, Newbould RD, Howard J, Miller SR, Bush MA, Hill S, Reiley R, Passchier J, Gunn RN, Matthews PM, Bullmore ET. Rabiner EA, et al. Mol Psychiatry. 2011 Aug;16(8):826-35, 785. doi: 10.1038/mp.2011.29. Epub 2011 Apr 19. Mol Psychiatry. 2011. PMID: 21502953 Free PMC article. Clinical Trial.
Within-subject comparison of [(11)C]-(+)-PHNO and [(11)C]raclopride sensitivity to acute amphetamine challenge in healthy humans.
Shotbolt P, Tziortzi AC, Searle GE, Colasanti A, van der Aart J, Abanades S, Plisson C, Miller SR, Huiban M, Beaver JD, Gunn RN, Laruelle M, Rabiner EA. Shotbolt P, et al. Among authors: searle ge. J Cereb Blood Flow Metab. 2012 Jan;32(1):127-36. doi: 10.1038/jcbfm.2011.115. Epub 2011 Aug 31. J Cereb Blood Flow Metab. 2012. PMID: 21878947 Free PMC article.
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