Searle PF - Search Results

1

Virus-directed enzyme prodrug therapy using CB1954.

Grove JI, Searle PF, Weedon SJ, Green NK, McNeish IA, Kerr DJ. Grove JI, et al. Among authors: searle pf. Anticancer Drug Des. 1999 Dec;14(6):461-72. Anticancer Drug Des. 1999. PMID: 10834268 Review.

2

Sensitization of colorectal and pancreatic cancer cell lines to the prodrug 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954) by retroviral transduction and expression of the E. coli nitroreductase gene.

Green NK, Youngs DJ, Neoptolemos JP, Friedlos F, Knox RJ, Springer CJ, Anlezark GM, Michael NP, Melton RG, Ford MJ, Young LS, Kerr DJ, Searle PF. Green NK, et al. Among authors: searle pf. Cancer Gene Ther. 1997 Jul-Aug;4(4):229-38. Cancer Gene Ther. 1997. PMID: 9253508

3

Adenoviral delivery of B7-1 (CD80) increases the immunogenicity of human ovarian and cervical carcinoma cells.

Gilligan MG, Knox P, Weedon S, Barton R, Kerr DJ, Searle P, Young LS. Gilligan MG, et al. Gene Ther. 1998 Jul;5(7):965-74. doi: 10.1038/sj.gt.3300672. Gene Ther. 1998. PMID: 9813668

4

Sensitisation of human ovarian cancer cells to killing by the prodrug CB1954 following retroviral or adenoviral transfer of the E. coli nitroreductase gene.

Searle PF, Weedon SJ, McNeish IA, Gilligan MG, Ford MJ, Friedlos F, Springer CJ, Young LS, Kerr DJ. Searle PF, et al. Adv Exp Med Biol. 1998;451:107-13. doi: 10.1007/978-1-4615-5357-1_17. Adv Exp Med Biol. 1998. PMID: 10026858 No abstract available.

5

Virus directed enzyme prodrug therapy for ovarian and pancreatic cancer using retrovirally delivered E. coli nitroreductase and CB1954.

McNeish IA, Green NK, Gilligan MG, Ford MJ, Mautner V, Young LS, Kerr DJ, Searle PF. McNeish IA, et al. Among authors: searle pf. Gene Ther. 1998 Aug;5(8):1061-9. doi: 10.1038/sj.gt.3300744. Gene Ther. 1998. PMID: 10326029

6

Gene therapy strategies for colon cancer.

Chung-Faye GA, Kerr DJ, Young LS, Searle PF. Chung-Faye GA, et al. Among authors: searle pf. Mol Med Today. 2000 Feb;6(2):82-7. doi: 10.1016/s1357-4310(99)01598-1. Mol Med Today. 2000. PMID: 10652481 Review.

7

Expression of Escherichia coli B nitroreductase in established human tumor xenografts in mice results in potent antitumoral and bystander effects upon systemic administration of the prodrug CB1954.

Djeha AH, Hulme A, Dexter MT, Mountain A, Young LS, Searle PF, Kerr DJ, Wrighton CJ. Djeha AH, et al. Among authors: searle pf. Cancer Gene Ther. 2000 May;7(5):721-31. doi: 10.1038/sj.cgt.7700171. Cancer Gene Ther. 2000. PMID: 10830719

8

Sensitisation of human carcinoma cells to the prodrug CB1954 by adenovirus vector-mediated expression of E. coli nitroreductase.

Weedon SJ, Green NK, McNeish IA, Gilligan MG, Mautner V, Wrighton CJ, Mountain A, Young LS, Kerr DJ, Searle PF. Weedon SJ, et al. Among authors: searle pf. Int J Cancer. 2000 Jun 15;86(6):848-54. doi: 10.1002/(sici)1097-0215(20000615)86:6<848::aid-ijc14>3.0.co;2-b. Int J Cancer. 2000. PMID: 10842200 Free article.

9

Combined adenovirus-mediated nitroreductase gene delivery and CB1954 treatment: a well-tolerated therapy for established solid tumors.

Djeha AH, Thomson TA, Leung H, Searle PF, Young LS, Kerr DJ, Harris PA, Mountain A, Wrighton CJ. Djeha AH, et al. Among authors: searle pf. Mol Ther. 2001 Feb;3(2):233-40. doi: 10.1006/mthe.2000.0250. Mol Ther. 2001. PMID: 11237680 Free article.

10

Tumour-specific therapeutic adenovirus vectors: repression of transgene expression in healthy cells by endogenous p53.

Lipinski KS, Djeha AH, Krausz E, Lane DP, Searle PF, Mountain A, Wrighton CJ. Lipinski KS, et al. Among authors: searle pf. Gene Ther. 2001 Feb;8(4):274-81. doi: 10.1038/sj.gt.3301403. Gene Ther. 2001. PMID: 11313801

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