Sebti SM - Search Results

1

A novel mechanism by which small molecule inhibitors induce the DFG flip in Aurora A.

Martin MP, Zhu JY, Lawrence HR, Pireddu R, Luo Y, Alam R, Ozcan S, Sebti SM, Lawrence NJ, Schönbrunn E. Martin MP, et al. Among authors: sebti sm. ACS Chem Biol. 2012 Apr 20;7(4):698-706. doi: 10.1021/cb200508b. Epub 2012 Jan 27. ACS Chem Biol. 2012. PMID: 22248356 Free PMC article.

2

Development of o-chlorophenyl substituted pyrimidines as exceptionally potent aurora kinase inhibitors.

Lawrence HR, Martin MP, Luo Y, Pireddu R, Yang H, Gevariya H, Ozcan S, Zhu JY, Kendig R, Rodriguez M, Elias R, Cheng JQ, Sebti SM, Schonbrunn E, Lawrence NJ. Lawrence HR, et al. Among authors: sebti sm. J Med Chem. 2012 Sep 13;55(17):7392-7416. doi: 10.1021/jm300334d. Epub 2012 Aug 30. J Med Chem. 2012. PMID: 22803810 Free PMC article.

3

RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer.

Patel RA, Forinash KD, Pireddu R, Sun Y, Sun N, Martin MP, Schönbrunn E, Lawrence NJ, Sebti SM. Patel RA, et al. Among authors: sebti sm. Cancer Res. 2012 Oct 1;72(19):5025-34. doi: 10.1158/0008-5472.CAN-12-0954. Epub 2012 Jul 30. Cancer Res. 2012. PMID: 22846914 Free PMC article.

4

Dual Aurora A and JAK2 kinase blockade effectively suppresses malignant transformation.

Yang H, Lawrence HR, Kazi A, Gevariya H, Patel R, Luo Y, Rix U, Schonbrunn E, Lawrence NJ, Sebti SM. Yang H, et al. Among authors: sebti sm. Oncotarget. 2014 May 30;5(10):2947-61. doi: 10.18632/oncotarget.1615. Oncotarget. 2014. PMID: 24930769 Free PMC article.

5

Discovery of a novel shp2 protein tyrosine phosphatase inhibitor.

Chen L, Sung SS, Yip ML, Lawrence HR, Ren Y, Guida WC, Sebti SM, Lawrence NJ, Wu J. Chen L, et al. Among authors: sebti sm. Mol Pharmacol. 2006 Aug;70(2):562-70. doi: 10.1124/mol.106.025536. Epub 2006 May 22. Mol Pharmacol. 2006. PMID: 16717135

6

Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds.

Lawrence HR, Pireddu R, Chen L, Luo Y, Sung SS, Szymanski AM, Yip ML, Guida WC, Sebti SM, Wu J, Lawrence NJ. Lawrence HR, et al. Among authors: sebti sm. J Med Chem. 2008 Aug 28;51(16):4948-56. doi: 10.1021/jm8002526. Epub 2008 Aug 5. J Med Chem. 2008. PMID: 18680359 Free PMC article.

7

Targeting protein tyrosine phosphatases for anticancer drug discovery.

Scott LM, Lawrence HR, Sebti SM, Lawrence NJ, Wu J. Scott LM, et al. Among authors: sebti sm. Curr Pharm Des. 2010 Jun;16(16):1843-62. doi: 10.2174/138161210791209027. Curr Pharm Des. 2010. PMID: 20337577 Free PMC article. Review.

8

Shp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogs.

Scott LM, Chen L, Daniel KG, Brooks WH, Guida WC, Lawrence HR, Sebti SM, Lawrence NJ, Wu J. Scott LM, et al. Among authors: sebti sm. Bioorg Med Chem Lett. 2011 Jan 15;21(2):730-3. doi: 10.1016/j.bmcl.2010.11.117. Epub 2010 Dec 4. Bioorg Med Chem Lett. 2011. PMID: 21193311 Free PMC article.

9

Discovery and synthesis of hydronaphthoquinones as novel proteasome inhibitors.

Ge Y, Kazi A, Marsilio F, Luo Y, Jain S, Brooks W, Daniel KG, Guida WC, Sebti SM, Lawrence HR. Ge Y, et al. Among authors: sebti sm. J Med Chem. 2012 Mar 8;55(5):1978-98. doi: 10.1021/jm201118h. Epub 2012 Feb 14. J Med Chem. 2012. PMID: 22220566 Free PMC article.

10

Fragment-based and structure-guided discovery and optimization of Rho kinase inhibitors.

Li R, Martin MP, Liu Y, Wang B, Patel RA, Zhu JY, Sun N, Pireddu R, Lawrence NJ, Li J, Haura EB, Sung SS, Guida WC, Schonbrunn E, Sebti SM. Li R, et al. Among authors: sebti sm. J Med Chem. 2012 Mar 8;55(5):2474-8. doi: 10.1021/jm201289r. Epub 2012 Feb 15. J Med Chem. 2012. PMID: 22272748 Free PMC article.

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