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The identification of a second cell cycle control on the HO promoter in yeast: cell cycle regulation of SW15 nuclear entry.
Nasmyth K, Adolf G, Lydall D, Seddon A. Nasmyth K, et al. Among authors: seddon a. Cell. 1990 Aug 24;62(4):631-47. doi: 10.1016/0092-8674(90)90110-z. Cell. 1990. PMID: 2167175
HO encodes a site-specific endonuclease that initiates mating type switching in S. cerevisiae. It is expressed only transiently during the cell cycle of mother cells, as they undergo Start, but not in daughter cells. ...A version of the HO promoter that has lost its …
HO encodes a site-specific endonuclease that initiates mating type switching in S. cerevisiae. It is expressed only transiently durin …
Characteristics of Plant Essential Genes Allow for within- and between-Species Prediction of Lethal Mutant Phenotypes.
Lloyd JP, Seddon AE, Moghe GD, Simenc MC, Shiu SH. Lloyd JP, et al. Among authors: seddon ae. Plant Cell. 2015 Aug;27(8):2133-47. doi: 10.1105/tpc.15.00051. Epub 2015 Aug 18. Plant Cell. 2015. PMID: 26286535 Free PMC article.
Essential genes in A. thaliana are often single copy or derived from older duplications, highly and broadly expressed, slow evolving, and highly connected within molecular networks compared with genes with nonlethal mutant phenotypes. ...Prediction models from A. th …
Essential genes in A. thaliana are often single copy or derived from older duplications, highly and broadly expressed, slow evolving, …
Cell cycle regulation of SW15 is required for mother-cell-specific HO transcription in yeast.
Nasmyth K, Seddon A, Ammerer G. Nasmyth K, et al. Among authors: seddon a. Cell. 1987 May 22;49(4):549-58. doi: 10.1016/0092-8674(87)90457-0. Cell. 1987. PMID: 3552251
In haploid homothallic yeast, cell division gives rise to a mother cell that transiently transcribes the HO gene (as it undergoes START) and a daughter cell that does not. ...Here, we test the proposition that a transcription factor called SWI5 is the "determ …
In haploid homothallic yeast, cell division gives rise to a mother cell that transiently transcribes the HO gene (as it undergoes STA …
Characterization of a transcription factor involved in mother cell specific transcription of the yeast HO gene.
Stillman DJ, Bankier AT, Seddon A, Groenhout EG, Nasmyth KA. Stillman DJ, et al. Among authors: seddon a. EMBO J. 1988 Feb;7(2):485-94. EMBO J. 1988. PMID: 3284746 Free PMC article.
It has been demonstrated that the SWI5 gene, which is an activator of HO expression, plays a critical role in this differential mother/daughter expression of HO. ...A region of the HO promoter involved in the SWI5-dependent transcriptional activation of HO was ident …
It has been demonstrated that the SWI5 gene, which is an activator of HO expression, plays a critical role in this differential mothe …
Predictive Models of Spatial Transcriptional Response to High Salinity.
Uygun S, Seddon AE, Azodi CB, Shiu SH. Uygun S, et al. Among authors: seddon ae. Plant Physiol. 2017 May;174(1):450-464. doi: 10.1104/pp.16.01828. Epub 2017 Apr 3. Plant Physiol. 2017. PMID: 28373393 Free PMC article.
Using Arabidopsis (Arabidopsis thaliana) as a model, we identified a set of 1,894 putative cis-regulatory elements (pCREs) that are associated with high-salinity (salt) up-regulated genes in the root or the shoot. ...Our results suggest that the plant organ transcri …
Using Arabidopsis (Arabidopsis thaliana) as a model, we identified a set of 1,894 putative cis-regulatory elements (pCREs) tha …
Characteristics and significance of intergenic polyadenylated RNA transcription in Arabidopsis.
Moghe GD, Lehti-Shiu MD, Seddon AE, Yin S, Chen Y, Juntawong P, Brandizzi F, Bailey-Serres J, Shiu SH. Moghe GD, et al. Among authors: seddon ae. Plant Physiol. 2013 Jan;161(1):210-24. doi: 10.1104/pp.112.205245. Epub 2012 Nov 6. Plant Physiol. 2013. PMID: 23132786 Free PMC article.
A surprisingly large number of ITFs (32.1%) may be protein coding based on evidence of translation. However, our results indicate that these "translated" ITFs tend to be close to and are likely associated with known genes. ...
A surprisingly large number of ITFs (32.1%) may be protein coding based on evidence of translation. However, our results indicate tha
Determinants of nucleosome positioning and their influence on plant gene expression.
Liu MJ, Seddon AE, Tsai ZT, Major IT, Floer M, Howe GA, Shiu SH. Liu MJ, et al. Among authors: seddon ae. Genome Res. 2015 Aug;25(8):1182-95. doi: 10.1101/gr.188680.114. Epub 2015 Jun 10. Genome Res. 2015. PMID: 26063739 Free PMC article.
Intriguingly, this 6-mer-specific nucleosome depletion pattern occurs not only in promoter but also in genic regions and is significantly correlated with higher gene expression level, a phenomenon also found in rice but not in yeast. ...Our study provides a global a …
Intriguingly, this 6-mer-specific nucleosome depletion pattern occurs not only in promoter but also in genic regions and is significantly co …
Cis-regulatory code of stress-responsive transcription in Arabidopsis thaliana.
Zou C, Sun K, Mackaluso JD, Seddon AE, Jin R, Thomashow MF, Shiu SH. Zou C, et al. Among authors: seddon ae. Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14992-7. doi: 10.1073/pnas.1103202108. Epub 2011 Aug 17. Proc Natl Acad Sci U S A. 2011. PMID: 21849619 Free PMC article.
Although substantial knowledge has accumulated on how a few plant cis-regulatory elements (CREs) function in stress regulation, many more CREs remain to be discovered. ...Furthermore, instead of a few master combinatorial rules for each stress condition, many rules …
Although substantial knowledge has accumulated on how a few plant cis-regulatory elements (CREs) function in stress regulation, many …
Experimental Investigation of Actively Q-Switched Er3+:ZBLAN Fiber Laser Operating at around 2.8 µm.
Sojka L, Pajewski L, Lamrini S, Farries M, Benson TM, Seddon AB, Sujecki S. Sojka L, et al. Among authors: seddon ab. Sensors (Basel). 2020 Aug 18;20(16):4642. doi: 10.3390/s20164642. Sensors (Basel). 2020. PMID: 32824714 Free PMC article.
Outcomes of COVID-19 in patients with CLL: a multicenter international experience.
Mato AR, Roeker LE, Lamanna N, Allan JN, Leslie L, Pagel JM, Patel K, Osterborg A, Wojenski D, Kamdar M, Huntington SF, Davids MS, Brown JR, Antic D, Jacobs R, Ahn IE, Pu J, Isaac KM, Barr PM, Ujjani CS, Geyer MB, Berman E, Zelenetz AD, Malakhov N, Furman RR, Koropsak M, Bailey N, Hanson L, Perini GF, Ma S, Ryan CE, Wiestner A, Portell CA, Shadman M, Chong EA, Brander DM, Sundaram S, Seddon AN, Seymour E, Patel M, Martinez-Calle N, Munir T, Walewska R, Broom A, Walter H, El-Sharkawi D, Parry H, Wilson MR, Patten PEM, Hernández-Rivas JÁ, Miras F, Fernández Escalada N, Ghione P, Nabhan C, Lebowitz S, Bhavsar E, López-Jiménez J, Naya D, Garcia-Marco JA, Skånland SS, Cordoba R, Eyre TA. Mato AR, et al. Among authors: seddon an. Blood. 2020 Sep 3;136(10):1134-1143. doi: 10.1182/blood.2020006965. Blood. 2020. PMID: 32688395 Free PMC article. Clinical Trial.
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