Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

My NCBI Filters
Text availability
Article attribute
Article type
Publication date

Search Results

100 results
Filters applied: . Clear all Results are displayed in a computed author sort order. Results by year timeline is unavailable
Page 1
The role of Trypanosoma brucei MRPA in melarsoprol susceptibility.
Alibu VP, Richter C, Voncken F, Marti G, Shahi S, Renggli CK, Seebeck T, Brun R, Clayton C. Alibu VP, et al. Mol Biochem Parasitol. 2006 Mar;146(1):38-44. doi: 10.1016/j.molbiopara.2005.10.016. Epub 2005 Nov 18. Mol Biochem Parasitol. 2006. PMID: 16343658
We previously showed that over-expression of Trypanosoma brucei MRPA, a member of the multidrug resistance protein family in T. brucei, reproducibly resulted in resistance to the anti-trypanosomal drug melarsoprol in vitro. ...
We previously showed that over-expression of Trypanosoma brucei MRPA, a member of the multidrug resistance protein family in T. bruce …
The Trypanosoma brucei cAMP phosphodiesterases TbrPDEB1 and TbrPDEB2: flagellar enzymes that are essential for parasite virulence.
Oberholzer M, Marti G, Baresic M, Kunz S, Hemphill A, Seebeck T. Oberholzer M, et al. FASEB J. 2007 Mar;21(3):720-31. doi: 10.1096/fj.06-6818com. Epub 2006 Dec 13. FASEB J. 2007. PMID: 17167070
Furthermore, they are compatible with the notion that the flagellum of T. brucei is an important site of cAMP signaling....
Furthermore, they are compatible with the notion that the flagellum of T. brucei is an important site of cAMP signaling....
Molecular pharmacology of adenosine transport in Trypanosoma brucei: P1/P2 revisited.
Geiser F, Lüscher A, de Koning HP, Seebeck T, Mäser P. Geiser F, et al. Mol Pharmacol. 2005 Sep;68(3):589-95. doi: 10.1124/mol.104.010298. Epub 2005 Jun 2. Mol Pharmacol. 2005. PMID: 15933219
T. brucei possess two distinct adenosine transport systems, P1 and P2, the latter of which also mediates cellular uptake of the drugs melarsoprol and pentamidine. ...
T. brucei possess two distinct adenosine transport systems, P1 and P2, the latter of which also mediates cellular uptake of the drugs
Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei.
Matovu E, Stewart ML, Geiser F, Brun R, Mäser P, Wallace LJ, Burchmore RJ, Enyaru JC, Barrett MP, Kaminsky R, Seebeck T, de Koning HP. Matovu E, et al. Eukaryot Cell. 2003 Oct;2(5):1003-8. doi: 10.1128/ec.2.5.1003-1008.2003. Eukaryot Cell. 2003. PMID: 14555482 Free PMC article.
In T. brucei, the uptake of melarsoprol as well as diamidines is thought to be mediated by the P2 aminopurine transporter, and loss of P2 function has been implicated in resistance to these agents. ...Here we investigate the role of TbAT1 in drug uptake and drug resistance …
In T. brucei, the uptake of melarsoprol as well as diamidines is thought to be mediated by the P2 aminopurine transporter, and loss o …
The cAMP-specific phosphodiesterase TbPDE2C is an essential enzyme in bloodstream form Trypanosoma brucei.
Zoraghi R, Seebeck T. Zoraghi R, et al. Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4343-8. doi: 10.1073/pnas.062716599. Proc Natl Acad Sci U S A. 2002. PMID: 11930001 Free PMC article.
This study reports the characterization of a cAMP-specific phosphodiesterase from T. brucei, TbPDE2C. This enzyme is a class I phosphodiesterase, and it is a member of a small enzyme family in T. brucei, TbPDE2. ...
This study reports the characterization of a cAMP-specific phosphodiesterase from T. brucei, TbPDE2C. This enzyme is a class I phosph …
Enhanced endothelial nitric oxide-synthase activity in mice infected with Trypanosoma brucei.
Viswambharan H, Seebeck T, Yang Z. Viswambharan H, et al. Int J Parasitol. 2003 Sep 15;33(10):1099-104. doi: 10.1016/s0020-7519(03)00180-2. Int J Parasitol. 2003. PMID: 13129532
The present study explores the effect of T. brucei infection on the endothelium-dependent in vitro vasomotor response of isolated mouse aortas. ...Thus, T. brucei infection enhances eNOS protein expression in the endothelium, causing a pronounced vasodilation. Overp …
The present study explores the effect of T. brucei infection on the endothelium-dependent in vitro vasomotor response of isolated mou …
Pharmacological validation of Trypanosoma brucei phosphodiesterases as novel drug targets.
de Koning HP, Gould MK, Sterk GJ, Tenor H, Kunz S, Luginbuehl E, Seebeck T. de Koning HP, et al. Among authors: seebeck t. J Infect Dis. 2012 Jul 15;206(2):229-37. doi: 10.1093/infdis/jir857. Epub 2012 Jan 30. J Infect Dis. 2012. PMID: 22291195 Free PMC article.
Trypanocidal action of neuroleptic phenothiazines in Trypanosoma brucei.
Seebeck T, Gehr P. Seebeck T, et al. Mol Biochem Parasitol. 1983 Nov;9(3):197-208. doi: 10.1016/0166-6851(83)90097-x. Mol Biochem Parasitol. 1983. PMID: 6144043
cAMP signalling in Trypanosoma brucei.
Seebeck T, Gong K, Kunz S, Schaub R, Shalaby T, Zoraghi R. Seebeck T, et al. Int J Parasitol. 2001 May 1;31(5-6):491-8. doi: 10.1016/s0020-7519(01)00164-3. Int J Parasitol. 2001. PMID: 11334934 Review.
A newly identified adenylyl cyclase, GRESAG4.4B, a member of a small family of closely related genes, is being used as a model molecule for investigating the mechanisms which control cyclase activity in the T. brucei cell. ...
A newly identified adenylyl cyclase, GRESAG4.4B, a member of a small family of closely related genes, is being used as a model molecule for …
100 results
Jump to page
Feedback