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Atypical antipsychotics: mechanism of action.
Seeman P. Seeman P. Can J Psychiatry. 2002 Feb;47(1):27-38. Can J Psychiatry. 2002. PMID: 11873706 Review.
Cell membrane lytic action of metoclopramide and its relation to tardive dyskinesia.
Lai TK, Seeman P, Liu F. Lai TK, et al. Among authors: seeman p. Synapse. 2012 Mar;66(3):273-6. doi: 10.1002/syn.21504. Epub 2011 Nov 29. Synapse. 2012. PMID: 22034087
Anesthetics inhibit high-affinity states of dopamine D2 and other G-linked receptors.
Seeman P, Kapur S. Seeman P, et al. Synapse. 2003 Oct;50(1):35-40. doi: 10.1002/syn.10221. Synapse. 2003. PMID: 12872292
Binding Interactions of Dopamine and Apomorphine in D2High and D2Low States of Human Dopamine D2 Receptor Using Computational and Experimental Techniques.
Durdagi S, Salmas RE, Stein M, Yurtsever M, Seeman P. Durdagi S, et al. Among authors: seeman p. ACS Chem Neurosci. 2016 Feb 17;7(2):185-95. doi: 10.1021/acschemneuro.5b00271. Epub 2015 Dec 22. ACS Chem Neurosci. 2016. PMID: 26645629
Clozapine, a fast-off-D2 antipsychotic.
Seeman P. Seeman P. ACS Chem Neurosci. 2014 Jan 15;5(1):24-9. doi: 10.1021/cn400189s. Epub 2013 Nov 18. ACS Chem Neurosci. 2014. PMID: 24219174 Free PMC article. Review.
Is schizophrenia a dopamine supersensitivity psychotic reaction?
Seeman MV, Seeman P. Seeman MV, et al. Among authors: seeman p. Prog Neuropsychopharmacol Biol Psychiatry. 2014 Jan 3;48:155-60. doi: 10.1016/j.pnpbp.2013.10.003. Epub 2013 Oct 12. Prog Neuropsychopharmacol Biol Psychiatry. 2014. PMID: 24128684 Free PMC article. Review.
Exposure to nicotine produces an increase in dopamine D2(High) receptors: a possible mechanism for dopamine hypersensitivity.
Novak G, Seeman P, Le Foll B. Novak G, et al. Among authors: seeman p. Int J Neurosci. 2010 Nov;120(11):691-7. doi: 10.3109/00207454.2010.513462. Int J Neurosci. 2010. PMID: 20942582
Less is more: antipsychotic drug effects are greater with transient rather than continuous delivery.
Samaha AN, Reckless GE, Seeman P, Diwan M, Nobrega JN, Kapur S. Samaha AN, et al. Among authors: seeman p. Biol Psychiatry. 2008 Jul 15;64(2):145-52. doi: 10.1016/j.biopsych.2008.01.010. Epub 2008 Mar 4. Biol Psychiatry. 2008. PMID: 18295747
"Breakthrough" dopamine supersensitivity during ongoing antipsychotic treatment leads to treatment failure over time.
Samaha AN, Seeman P, Stewart J, Rajabi H, Kapur S. Samaha AN, et al. Among authors: seeman p. J Neurosci. 2007 Mar 14;27(11):2979-86. doi: 10.1523/JNEUROSCI.5416-06.2007. J Neurosci. 2007. PMID: 17360921 Free PMC article.
Radiosynthesis and evaluation of [11C]-(+)-4-propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol as a potential radiotracer for in vivo imaging of the dopamine D2 high-affinity state with positron emission tomography.
Wilson AA, McCormick P, Kapur S, Willeit M, Garcia A, Hussey D, Houle S, Seeman P, Ginovart N. Wilson AA, et al. Among authors: seeman p. J Med Chem. 2005 Jun 16;48(12):4153-60. doi: 10.1021/jm050155n. J Med Chem. 2005. PMID: 15943487
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