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76 results

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Page 1
Fungal Attachment-Resistant Polymers for the Additive Manufacture of Medical Devices.
Yong LX, Sefton J, Vallières C, Rance GA, Hill J, Cuzzucoli Crucitti V, Dundas AA, Rose FRAJ, Alexander MR, Wildman R, He Y, Avery SV, Irvine DJ. Yong LX, et al. ACS Appl Mater Interfaces. 2024 Oct 9;16(40):54508-54519. doi: 10.1021/acsami.4c04833. Epub 2024 Sep 30. ACS Appl Mater Interfaces. 2024. PMID: 39349401 Free PMC article.
Of the copolymers produced, triethylene glycol methyl ether methacrylate (TEGMA) copolymerized with (r)-alpha-acryloyloxy-beta,beta-dimethyl-gamma-butyrolactone (AODMBA) at a 40:60 copolymer ratio was found to be the most promising candidate by meeting all of the above cri …
Of the copolymers produced, triethylene glycol methyl ether methacrylate (TEGMA) copolymerized with (r)-alpha-acryloyloxy-beta,beta-d …
Aspects of the alternative host response to methacrylic acid containing biomaterials.
Ortaleza K, Won SY, Kinney SM, Sefton MV. Ortaleza K, et al. J Biomed Mater Res A. 2024 Aug;112(8):1276-1285. doi: 10.1002/jbm.a.37652. Epub 2023 Dec 6. J Biomed Mater Res A. 2024. PMID: 38053493
Methacrylic acid (MAA)-based biomaterials promote a vascularized host response without the addition of exogenous factors such as cells or growth factors. ...
Methacrylic acid (MAA)-based biomaterials promote a vascularized host response without the addition of exogenous factors such as cell …
Effect of Cell Density of a Methacrylic Acid-Based Hydrogel Implant on Embedded Islet Function and Viability.
Ortaleza K, Sefton MV. Ortaleza K, et al. Tissue Eng Part A. 2024 Mar;30(5-6):204-213. doi: 10.1089/ten.TEA.2023.0155. Epub 2023 Dec 19. Tissue Eng Part A. 2024. PMID: 37962272
Subcutaneous delivery of islets in a methacrylic acid-based hydrogel may offer a functional cure for type 1 diabetes. Here we show in mice that the hydrogel is able to provide sufficient vasculature to support islet function and viability, when islets are used at a low isl …
Subcutaneous delivery of islets in a methacrylic acid-based hydrogel may offer a functional cure for type 1 diabetes. Here we show in …
Screening of Oligomeric (Meth)acrylate Vaccine Adjuvants Synthesized via Catalytic Chain Transfer Polymerization.
Hege CS, Stimpson A, Sefton J, Summers J, Henke H, Dundas AA, Phan T, Kinsey R, Guderian JA, Sivananthan SJ, Mohamath R, Lykins WR, Ramer-Denisoff G, Lin S, Fox CB, Irvine DJ. Hege CS, et al. Polymers (Basel). 2023 Sep 20;15(18):3831. doi: 10.3390/polym15183831. Polymers (Basel). 2023. PMID: 37765685 Free PMC article.
This report details the first systematic screening of free-radical-produced methacrylate oligomer reaction mixtures as alternative vaccine adjuvant components to replace the current benchmark compound squalene, which is unsustainably sourced from shark livers. Homo-/co-oli …
This report details the first systematic screening of free-radical-produced methacrylate oligomer reaction mixtures as alternative va …
Immunomodulation by subcutaneously injected methacrylic acid-based hydrogels and tolerogenic dendritic cells in a mouse model of autoimmune diabetes.
Kinney SM, Ortaleza K, Won SY, Licht BJM, Sefton MV. Kinney SM, et al. Biomaterials. 2023 Oct;301:122265. doi: 10.1016/j.biomaterials.2023.122265. Epub 2023 Aug 1. Biomaterials. 2023. PMID: 37586232
In this study we show that degradable, synthetic methacrylic acid (MAA)-based hydrogels are an inherently immunomodulating delivery vehicle that enhances tolerogenic DC therapy in the context of autoimmune diabetes. ...
In this study we show that degradable, synthetic methacrylic acid (MAA)-based hydrogels are an inherently immunomodulating delivery v …
Degradable methacrylic acid-based synthetic hydrogel for subcutaneous islet transplantation.
Kinney SM, Ortaleza K, Vlahos AE, Sefton MV. Kinney SM, et al. Biomaterials. 2022 Feb;281:121342. doi: 10.1016/j.biomaterials.2021.121342. Epub 2021 Dec 30. Biomaterials. 2022. PMID: 34995903
In this study we demonstrate that islets engraft in the subcutaneous space when injected in an inherently vascularizing, degradable methacrylic acid-polyethylene glycol (MAA-PEG) hydrogel; no vascularizing cells or growth factors were required. ...
In this study we demonstrate that islets engraft in the subcutaneous space when injected in an inherently vascularizing, degradable metha …
Methacrylic acid-based hydrogels enhance skeletal muscle regeneration after volumetric muscle loss in mice.
Carleton MM, Locke M, Sefton MV. Carleton MM, et al. Biomaterials. 2021 Aug;275:120909. doi: 10.1016/j.biomaterials.2021.120909. Epub 2021 May 24. Biomaterials. 2021. PMID: 34087582
Regenerative biomaterials, such as those containing methacrylic-acid (MAA), are proposed as a novel approach to enhancing muscle regeneration without added cells, growth factors or drugs. ...
Regenerative biomaterials, such as those containing methacrylic-acid (MAA), are proposed as a novel approach to enhancing muscle rege …
Poly-Methacrylic Acid Cross-Linked with Collagen Accelerates Diabetic Wound Closure.
Coindre VF, Hu Y, Sefton MV. Coindre VF, et al. ACS Biomater Sci Eng. 2020 Nov 9;6(11):6368-6377. doi: 10.1021/acsbiomaterials.0c01222. Epub 2020 Oct 27. ACS Biomater Sci Eng. 2020. PMID: 33449665
Nonbiologic vascular regenerative materials made of methacrylic acid (MAA) copolymer, such as MAA-co-methyl methacrylate beads, have shown to enhance wound healing in a diabetic animal model, but their lack of biodegradability precludes their clinical implementation …
Nonbiologic vascular regenerative materials made of methacrylic acid (MAA) copolymer, such as MAA-co-methyl methacrylate beads …
76 results