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Aspects of the alternative host response to methacrylic acid containing biomaterials.
Ortaleza K, Won SY, Kinney SM, Sefton MV. Ortaleza K, et al. J Biomed Mater Res A. 2024 Aug;112(8):1276-1285. doi: 10.1002/jbm.a.37652. Epub 2023 Dec 6. J Biomed Mater Res A. 2024. PMID: 38053493
Methacrylic acid (MAA)-based biomaterials promote a vascularized host response without the addition of exogenous factors such as cells or growth factors. ...We also compared the host response to a MAA-PEG (polyethylene glycol) hydrogel at day 1, with pancreat …
Methacrylic acid (MAA)-based biomaterials promote a vascularized host response without the addition of exogenous factors such as cell …
Degradable methacrylic acid-based synthetic hydrogel for subcutaneous islet transplantation.
Kinney SM, Ortaleza K, Vlahos AE, Sefton MV. Kinney SM, et al. Biomaterials. 2022 Feb;281:121342. doi: 10.1016/j.biomaterials.2021.121342. Epub 2021 Dec 30. Biomaterials. 2022. PMID: 34995903
In this study we demonstrate that islets engraft in the subcutaneous space when injected in an inherently vascularizing, degradable methacrylic acid-polyethylene glycol (MAA-PEG) hydrogel; no vascularizing cells or growth factors were required. ...Our finding …
In this study we demonstrate that islets engraft in the subcutaneous space when injected in an inherently vascularizing, degradable metha …
Methacrylic acid-based hydrogels enhance skeletal muscle regeneration after volumetric muscle loss in mice.
Carleton MM, Locke M, Sefton MV. Carleton MM, et al. Biomaterials. 2021 Aug;275:120909. doi: 10.1016/j.biomaterials.2021.120909. Epub 2021 May 24. Biomaterials. 2021. PMID: 34087582
Here, the regenerative effects of two hydrogels were investigated: MAA-poly(ethylene glycol) (MAA-PEG) and MAA-collagen. These hydrogels were used to treat VML injuries in murine tibialis anterior muscles. ...While both hydrogels increased vascularizat …
Here, the regenerative effects of two hydrogels were investigated: MAA-poly(ethylene glycol) (MAA-PEG) and MAA-collagen. These …
Injectable and degradable methacrylic acid hydrogel alters macrophage response in skeletal muscle.
Carleton MM, Sefton MV. Carleton MM, et al. Biomaterials. 2019 Dec;223:119477. doi: 10.1016/j.biomaterials.2019.119477. Epub 2019 Sep 5. Biomaterials. 2019. PMID: 31521886
To study the innate immune response to MAA in skeletal muscle, MAA-poly(ethylene glycol) (MAA-PEG) hydrogels were synthesized with degradation rates of either 2 (fast-degrading) or 7 days (slow-degrading). ...Overall, this study shows that MAA hydrogels bias …
To study the innate immune response to MAA in skeletal muscle, MAA-poly(ethylene glycol) (MAA-PEG) hydrogels were synthesized …
Injectable and inherently vascularizing semi-interpenetrating polymer network for delivering cells to the subcutaneous space.
Mahou R, Zhang DKY, Vlahos AE, Sefton MV. Mahou R, et al. Biomaterials. 2017 Jul;131:27-35. doi: 10.1016/j.biomaterials.2017.03.032. Epub 2017 Mar 24. Biomaterials. 2017. PMID: 28371625
Injectable hydrogels are suitable for local cell delivery to the subcutaneous space, but the lack of vasculature remains a limiting factor. Previously we demonstrated that biomaterials containing methacrylic acid promoted vascularization. Here we report the preparat …
Injectable hydrogels are suitable for local cell delivery to the subcutaneous space, but the lack of vasculature remains a limiting f …