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Activation of NADPH oxidase involves the dissociation of p21rac from its inhibitory GDP/GTP exchange protein (rhoGDI) followed by its translocation to the plasma membrane.
Abo A, Webb MR, Grogan A, Segal AW. Abo A, et al. Among authors: segal aw. Biochem J. 1994 Mar 15;298 Pt 3(Pt 3):585-91. doi: 10.1042/bj2980585. Biochem J. 1994. PMID: 8141770 Free PMC article.
Effects of microinjected small GTPases on the actin cytoskeleton of human neutrophils.
Bird MM, Lopez-Lluch G, Ridley AJ, Segal AW. Bird MM, et al. Among authors: segal aw. J Anat. 2003 Oct;203(4):379-89. doi: 10.1046/j.1469-7580.2003.00222.x. J Anat. 2003. PMID: 14620378 Free PMC article.
The major phosphorylation site of the NADPH oxidase component p67phox is Thr233.
Forbes LV, Truong O, Wientjes FB, Moss SJ, Segal AW. Forbes LV, et al. Among authors: segal aw. Biochem J. 1999 Feb 15;338 ( Pt 1)(Pt 1):99-105. Biochem J. 1999. PMID: 9931304 Free PMC article.
Phosphorylation of p67phox in the neutrophil occurs in the cytosol and is independent of p47phox.
Forbes LV, Moss SJ, Segal AW. Forbes LV, et al. Among authors: segal aw. FEBS Lett. 1999 Apr 23;449(2-3):225-9. doi: 10.1016/s0014-5793(99)00444-5. FEBS Lett. 1999. PMID: 10338137
The NADPH oxidase components p47(phox) and p40(phox) bind to moesin through their PX domain.
Wientjes FB, Reeves EP, Soskic V, Furthmayr H, Segal AW. Wientjes FB, et al. Among authors: segal aw. Biochem Biophys Res Commun. 2001 Nov 30;289(2):382-8. doi: 10.1006/bbrc.2001.5982. Biochem Biophys Res Commun. 2001. PMID: 11716484
NADPH oxidase is not essential for low density lipoprotein oxidation by human monocyte-derived macrophages.
Wilkins GM, Segal AW, Leake DS. Wilkins GM, et al. Among authors: segal aw. Biochem Biophys Res Commun. 1994 Aug 15;202(3):1300-7. doi: 10.1006/bbrc.1994.2072. Biochem Biophys Res Commun. 1994. PMID: 8060307
Interaction of Rac with p67phox and regulation of phagocytic NADPH oxidase activity.
Diekmann D, Abo A, Johnston C, Segal AW, Hall A. Diekmann D, et al. Among authors: segal aw. Science. 1994 Jul 22;265(5171):531-3. doi: 10.1126/science.8036496. Science. 1994. PMID: 8036496
Functional reconstitution of the NADPH-oxidase by adeno-associated virus gene transfer.
Thrasher AJ, de Alwis M, Casimir CM, Kinnon C, Page K, Lebkowski J, Segal AW, Levinsky RJ. Thrasher AJ, et al. Among authors: segal aw. Blood. 1995 Jul 15;86(2):761-5. Blood. 1995. PMID: 7606005
Generation of recombinant adeno-associated virus (rAAV) from an adenoviral vector and functional reconstitution of the NADPH-oxidase.
Thrasher AJ, de Alwis M, Casimir CM, Kinnon C, Page K, Lebkowski J, Segal AW, Levinsky RJ. Thrasher AJ, et al. Among authors: segal aw. Gene Ther. 1995 Sep;2(7):481-5. Gene Ther. 1995. PMID: 7584126
Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1.
Abo A, Pick E, Hall A, Totty N, Teahan CG, Segal AW. Abo A, et al. Among authors: segal aw. Nature. 1991 Oct 17;353(6345):668-70. doi: 10.1038/353668a0. Nature. 1991. PMID: 1922386
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