Segal DJ - Search Results

1

Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases.

Szczepek M, Brondani V, Büchel J, Serrano L, Segal DJ, Cathomen T. Szczepek M, et al. Among authors: segal dj. Nat Biotechnol. 2007 Jul;25(7):786-93. doi: 10.1038/nbt1317. Epub 2007 Jul 1. Nat Biotechnol. 2007. PMID: 17603476

2

Generation and functional analysis of zinc finger nucleases.

Cathomen T, Segal DJ, Brondani V, Müller-Lerch F. Cathomen T, et al. Among authors: segal dj. Methods Mol Biol. 2008;434:277-90. doi: 10.1007/978-1-60327-248-3_17. Methods Mol Biol. 2008. PMID: 18470651

3

Custom zinc-finger nucleases for use in human cells.

Alwin S, Gere MB, Guhl E, Effertz K, Barbas CF 3rd, Segal DJ, Weitzman MD, Cathomen T. Alwin S, et al. Among authors: segal dj. Mol Ther. 2005 Oct;12(4):610-7. doi: 10.1016/j.ymthe.2005.06.094. Mol Ther. 2005. PMID: 16039907 Free article.

4

Adding fingers to an engineered zinc finger nuclease can reduce activity.

Shimizu Y, Şöllü C, Meckler JF, Adriaenssens A, Zykovich A, Cathomen T, Segal DJ. Shimizu Y, et al. Among authors: segal dj. Biochemistry. 2011 Jun 7;50(22):5033-41. doi: 10.1021/bi200393g. Epub 2011 May 11. Biochemistry. 2011. PMID: 21528840 Free PMC article.

5

Critical parameters for genome editing using zinc finger nucleases.

Camenisch TD, Brilliant MH, Segal DJ. Camenisch TD, et al. Among authors: segal dj. Mini Rev Med Chem. 2008 Jun;8(7):669-76. doi: 10.2174/138955708784567458. Mini Rev Med Chem. 2008. PMID: 18537722 Review.

6

Restricted spacer tolerance of a zinc finger nuclease with a six amino acid linker.

Shimizu Y, Bhakta MS, Segal DJ. Shimizu Y, et al. Among authors: segal dj. Bioorg Med Chem Lett. 2009 Jul 15;19(14):3970-2. doi: 10.1016/j.bmcl.2009.02.109. Epub 2009 Mar 3. Bioorg Med Chem Lett. 2009. PMID: 19289279 Free PMC article.

7

The generation of zinc finger proteins by modular assembly.

Bhakta MS, Segal DJ. Bhakta MS, et al. Among authors: segal dj. Methods Mol Biol. 2010;649:3-30. doi: 10.1007/978-1-60761-753-2_1. Methods Mol Biol. 2010. PMID: 20680825 Free PMC article.

8

Custom DNA-binding proteins come of age: polydactyl zinc-finger proteins.

Segal DJ, Barbas CF 3rd. Segal DJ, et al. Curr Opin Biotechnol. 2001 Dec;12(6):632-7. doi: 10.1016/s0958-1669(01)00272-5. Curr Opin Biotechnol. 2001. PMID: 11849947 Review.

9

Structure of Aart, a designed six-finger zinc finger peptide, bound to DNA.

Segal DJ, Crotty JW, Bhakta MS, Barbas CF 3rd, Horton NC. Segal DJ, et al. J Mol Biol. 2006 Oct 20;363(2):405-21. doi: 10.1016/j.jmb.2006.08.016. Epub 2006 Aug 11. J Mol Biol. 2006. PMID: 16963084

10

The use of zinc finger peptides to study the role of specific factor binding sites in the chromatin environment.

Segal DJ. Segal DJ. Methods. 2002 Jan;26(1):76-83. doi: 10.1016/S1046-2023(02)00009-9. Methods. 2002. PMID: 12054906

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