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16 results
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Colorectal cancer and genetic alterations in the Wnt pathway.
Segditsas S, Tomlinson I. Segditsas S, et al. Oncogene. 2006 Dec 4;25(57):7531-7. doi: 10.1038/sj.onc.1210059. Oncogene. 2006. PMID: 17143297 Review.
APC and the three-hit hypothesis.
Segditsas S, Rowan AJ, Howarth K, Jones A, Leedham S, Wright NA, Gorman P, Chambers W, Domingo E, Roylance RR, Sawyer EJ, Sieber OM, Tomlinson IP. Segditsas S, et al. Oncogene. 2009 Jan 8;28(1):146-55. doi: 10.1038/onc.2008.361. Epub 2008 Oct 6. Oncogene. 2009. PMID: 18836487
Analysis of copy number changes suggests chromosomal instability in a minority of large colorectal adenomas.
Jones AM, Thirlwell C, Howarth KM, Graham T, Chambers W, Segditsas S, Page KM, Phillips RK, Thomas HJ, Sieber OM, Sawyer EJ, Tomlinson IP. Jones AM, et al. Among authors: segditsas s. J Pathol. 2007 Nov;213(3):249-56. doi: 10.1002/path.2234. J Pathol. 2007. PMID: 17893889
Investigation of pathogenic mechanisms in multiple colorectal adenoma patients without germline APC or MYH/MUTYH mutations.
Thirlwell C, Howarth KM, Segditsas S, Guerra G, Thomas HJ, Phillips RK, Talbot IC, Gorman M, Novelli MR, Sieber OM, Tomlinson IP. Thirlwell C, et al. Among authors: segditsas s. Br J Cancer. 2007 Jun 4;96(11):1729-34. doi: 10.1038/sj.bjc.6603789. Epub 2007 May 15. Br J Cancer. 2007. PMID: 17505512 Free PMC article.
Disease severity and genetic pathways in attenuated familial adenomatous polyposis vary greatly but depend on the site of the germline mutation.
Sieber OM, Segditsas S, Knudsen AL, Zhang J, Luz J, Rowan AJ, Spain SL, Thirlwell C, Howarth KM, Jaeger EE, Robinson J, Volikos E, Silver A, Kelly G, Aretz S, Frayling I, Hutter P, Dunlop M, Guenther T, Neale K, Phillips R, Heinimann K, Tomlinson IP. Sieber OM, et al. Among authors: segditsas s. Gut. 2006 Oct;55(10):1440-8. doi: 10.1136/gut.2005.087106. Epub 2006 Feb 4. Gut. 2006. PMID: 16461775 Free PMC article.
The Apc 1322T mouse develops severe polyposis associated with submaximal nuclear beta-catenin expression.
Pollard P, Deheragoda M, Segditsas S, Lewis A, Rowan A, Howarth K, Willis L, Nye E, McCart A, Mandir N, Silver A, Goodlad R, Stamp G, Cockman M, East P, Spencer-Dene B, Poulsom R, Wright N, Tomlinson I. Pollard P, et al. Among authors: segditsas s. Gastroenterology. 2009 Jun;136(7):2204-2213.e1-13. doi: 10.1053/j.gastro.2009.02.058. Epub 2009 Feb 25. Gastroenterology. 2009. PMID: 19248780
A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts.
Leedham SJ, Rodenas-Cuadrado P, Howarth K, Lewis A, Mallappa S, Segditsas S, Davis H, Jeffery R, Rodriguez-Justo M, Keshav S, Travis SP, Graham TA, East J, Clark S, Tomlinson IP. Leedham SJ, et al. Among authors: segditsas s. Gut. 2013 Jan;62(1):83-93. doi: 10.1136/gutjnl-2011-301601. Epub 2012 Jan 27. Gut. 2013. PMID: 22287596 Free PMC article.
Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1.
Jaeger E, Leedham S, Lewis A, Segditsas S, Becker M, Cuadrado PR, Davis H, Kaur K, Heinimann K, Howarth K; HMPS Collaboration, East J, Taylor J, Thomas H, Tomlinson I. Jaeger E, et al. Among authors: segditsas s. Nat Genet. 2012 May 6;44(6):699-703. doi: 10.1038/ng.2263. Nat Genet. 2012. PMID: 22561515 Free PMC article.
The C-terminus of Apc does not influence intestinal adenoma development or progression.
Lewis A, Davis H, Deheragoda M, Pollard P, Nye E, Jeffery R, Segditsas S, East P, Poulsom R, Stamp G, Wright N, Tomlinson I. Lewis A, et al. Among authors: segditsas s. J Pathol. 2012 Jan;226(1):73-83. doi: 10.1002/path.2972. Epub 2011 Oct 18. J Pathol. 2012. PMID: 22009253 Free PMC article.
Down-regulation of serum/glucocorticoid regulated kinase 1 in colorectal tumours is largely independent of promoter hypermethylation.
Lessi F, Beggs A, de Palo M, Anti M, Macarone Palmieri R, Francesconi S, Gomes V, Bevilacqua G, Tomlinson I, Segditsas S. Lessi F, et al. Among authors: segditsas s. PLoS One. 2010 Nov 5;5(11):e13840. doi: 10.1371/journal.pone.0013840. PLoS One. 2010. PMID: 21079778 Free PMC article.
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