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The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation.
Walter AO, Seghezzi W, Korver W, Sheung J, Lees E. Walter AO, et al. Among authors: seghezzi w. Oncogene. 2000 Oct 5;19(42):4906-16. doi: 10.1038/sj.onc.1203847. Oncogene. 2000. PMID: 11039908
AuroraA overexpression overrides the mitotic spindle checkpoint triggered by nocodazole, a microtubule destabilizer.
Jiang Y, Zhang Y, Lees E, Seghezzi W. Jiang Y, et al. Among authors: seghezzi w. Oncogene. 2003 Nov 13;22(51):8293-301. doi: 10.1038/sj.onc.1206873. Oncogene. 2003. PMID: 14614453
Dinaciclib (SCH 727965), a novel and potent cyclin-dependent kinase inhibitor.
Parry D, Guzi T, Shanahan F, Davis N, Prabhavalkar D, Wiswell D, Seghezzi W, Paruch K, Dwyer MP, Doll R, Nomeir A, Windsor W, Fischmann T, Wang Y, Oft M, Chen T, Kirschmeier P, Lees EM. Parry D, et al. Among authors: seghezzi w. Mol Cancer Ther. 2010 Aug;9(8):2344-53. doi: 10.1158/1535-7163.MCT-10-0324. Epub 2010 Jul 27. Mol Cancer Ther. 2010. PMID: 20663931
Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest.
Shanahan F, Seghezzi W, Parry D, Mahony D, Lees E. Shanahan F, et al. Among authors: seghezzi w. Mol Cell Biol. 1999 Feb;19(2):1460-9. doi: 10.1128/mcb.19.2.1460. Mol Cell Biol. 1999. PMID: 9891079 Free PMC article.
Cyclin C/CDK8 is a novel CTD kinase associated with RNA polymerase II.
Rickert P, Seghezzi W, Shanahan F, Cho H, Lees E. Rickert P, et al. Among authors: seghezzi w. Oncogene. 1996 Jun 20;12(12):2631-40. Oncogene. 1996. PMID: 8700522
Cyclin E associates with components of the pre-mRNA splicing machinery in mammalian cells.
Seghezzi W, Chua K, Shanahan F, Gozani O, Reed R, Lees E. Seghezzi W, et al. Mol Cell Biol. 1998 Aug;18(8):4526-36. doi: 10.1128/mcb.18.8.4526. Mol Cell Biol. 1998. PMID: 9671462 Free PMC article.
A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells.
Kumagai H, Sato N, Yamada M, Mahony D, Seghezzi W, Lees E, Arai K, Masai H. Kumagai H, et al. Among authors: seghezzi w. Mol Cell Biol. 1999 Jul;19(7):5083-95. doi: 10.1128/mcb.19.7.5083. Mol Cell Biol. 1999. PMID: 10373557 Free PMC article.
Targeting the replication checkpoint using SCH 900776, a potent and functionally selective CHK1 inhibitor identified via high content screening.
Guzi TJ, Paruch K, Dwyer MP, Labroli M, Shanahan F, Davis N, Taricani L, Wiswell D, Seghezzi W, Penaflor E, Bhagwat B, Wang W, Gu D, Hsieh Y, Lee S, Liu M, Parry D. Guzi TJ, et al. Among authors: seghezzi w. Mol Cancer Ther. 2011 Apr;10(4):591-602. doi: 10.1158/1535-7163.MCT-10-0928. Epub 2011 Feb 14. Mol Cancer Ther. 2011. PMID: 21321066
Pyrazolo[1,5-a]pyrimidines as orally available inhibitors of cyclin-dependent kinase 2.
Paruch K, Dwyer MP, Alvarez C, Brown C, Chan TY, Doll RJ, Keertikar K, Knutson C, McKittrick B, Rivera J, Rossman R, Tucker G, Fischmann TO, Hruza A, Madison V, Nomeir AA, Wang Y, Lees E, Parry D, Sgambellone N, Seghezzi W, Schultz L, Shanahan F, Wiswell D, Xu X, Zhou Q, James RA, Paradkar VM, Park H, Rokosz LR, Stauffer TM, Guzi TJ. Paruch K, et al. Among authors: seghezzi w. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6220-3. doi: 10.1016/j.bmcl.2007.09.017. Epub 2007 Sep 8. Bioorg Med Chem Lett. 2007. PMID: 17904841
Phosphorylation of spliceosomal protein SAP 155 coupled with splicing catalysis.
Wang C, Chua K, Seghezzi W, Lees E, Gozani O, Reed R. Wang C, et al. Among authors: seghezzi w. Genes Dev. 1998 May 15;12(10):1409-14. doi: 10.1101/gad.12.10.1409. Genes Dev. 1998. PMID: 9585501 Free PMC article.
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