Seibler J - Search Results

1

Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b.

Kornfeld JW, Baitzel C, Könner AC, Nicholls HT, Vogt MC, Herrmanns K, Scheja L, Haumaitre C, Wolf AM, Knippschild U, Seibler J, Cereghini S, Heeren J, Stoffel M, Brüning JC. Kornfeld JW, et al. Among authors: seibler j. Nature. 2013 Feb 7;494(7435):111-5. doi: 10.1038/nature11793. Nature. 2013. PMID: 23389544

2

Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism.

Jordan SD, Krüger M, Willmes DM, Redemann N, Wunderlich FT, Brönneke HS, Merkwirth C, Kashkar H, Olkkonen VM, Böttger T, Braun T, Seibler J, Brüning JC. Jordan SD, et al. Among authors: seibler j. Nat Cell Biol. 2011 Apr;13(4):434-46. doi: 10.1038/ncb2211. Epub 2011 Mar 27. Nat Cell Biol. 2011. PMID: 21441927

3

Central insulin action regulates peripheral glucose and fat metabolism in mice.

Koch L, Wunderlich FT, Seibler J, Könner AC, Hampel B, Irlenbusch S, Brabant G, Kahn CR, Schwenk F, Brüning JC. Koch L, et al. Among authors: seibler j. J Clin Invest. 2008 Jun;118(6):2132-47. doi: 10.1172/JCI31073. J Clin Invest. 2008. PMID: 18451994 Free PMC article.

4

Reversible gene knockdown in mice using a tight, inducible shRNA expression system.

Seibler J, Kleinridders A, Küter-Luks B, Niehaves S, Brüning JC, Schwenk F. Seibler J, et al. Nucleic Acids Res. 2007;35(7):e54. doi: 10.1093/nar/gkm122. Epub 2007 Mar 21. Nucleic Acids Res. 2007. PMID: 17376804 Free PMC article.

5

Single copy shRNA configuration for ubiquitous gene knockdown in mice.

Seibler J, Küter-Luks B, Kern H, Streu S, Plum L, Mauer J, Kühn R, Brüning JC, Schwenk F. Seibler J, et al. Nucleic Acids Res. 2005 Apr 14;33(7):e67. doi: 10.1093/nar/gni065. Nucleic Acids Res. 2005. PMID: 15831785 Free PMC article.

6

Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity.

Plum L, Ma X, Hampel B, Balthasar N, Coppari R, Münzberg H, Shanabrough M, Burdakov D, Rother E, Janoschek R, Alber J, Belgardt BF, Koch L, Seibler J, Schwenk F, Fekete C, Suzuki A, Mak TW, Krone W, Horvath TL, Ashcroft FM, Brüning JC. Plum L, et al. Among authors: seibler j. J Clin Invest. 2006 Jul;116(7):1886-901. doi: 10.1172/JCI27123. Epub 2006 Jun 22. J Clin Invest. 2006. PMID: 16794735 Free PMC article.

7

Transgenic RNAi applications in the mouse.

Seibler J, Schwenk F. Seibler J, et al. Methods Enzymol. 2010;477:367-86. doi: 10.1016/S0076-6879(10)77019-1. Methods Enzymol. 2010. PMID: 20699151

8

Lgr6 is a stem cell marker in mouse skin squamous cell carcinoma.

Huang PY, Kandyba E, Jabouille A, Sjolund J, Kumar A, Halliwill K, McCreery M, DelRosario R, Kang HC, Wong CE, Seibler J, Beuger V, Pellegrino M, Sciambi A, Eastburn DJ, Balmain A. Huang PY, et al. Among authors: seibler j. Nat Genet. 2017 Nov;49(11):1624-1632. doi: 10.1038/ng.3957. Epub 2017 Sep 25. Nat Genet. 2017. PMID: 28945253 Free PMC article.

9

Inducible transgenic rat model for diabetes mellitus based on shRNA-mediated gene knockdown.

Kotnik K, Popova E, Todiras M, Mori MA, Alenina N, Seibler J, Bader M. Kotnik K, et al. Among authors: seibler j. PLoS One. 2009;4(4):e5124. doi: 10.1371/journal.pone.0005124. Epub 2009 Apr 2. PLoS One. 2009. PMID: 19340286 Free PMC article.

10

Inducible and reversible gene silencing by stable integration of an shRNA-encoding lentivirus in transgenic rats.

Herold MJ, van den Brandt J, Seibler J, Reichardt HM. Herold MJ, et al. Among authors: seibler j. Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18507-12. doi: 10.1073/pnas.0806213105. Epub 2008 Nov 18. Proc Natl Acad Sci U S A. 2008. PMID: 19017805 Free PMC article.

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