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The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo[a]pyrene: effects in Trp53(+/+), Trp53(+/-) and Trp53(-/-) mice.
Krais AM, Speksnijder EN, Melis JP, Indra R, Moserova M, Godschalk RW, van Schooten FJ, Seidel A, Kopka K, Schmeiser HH, Stiborova M, Phillips DH, Luijten M, Arlt VM. Krais AM, et al. Among authors: seidel a. Arch Toxicol. 2016 Apr;90(4):839-51. doi: 10.1007/s00204-015-1531-8. Epub 2015 May 21. Arch Toxicol. 2016. PMID: 25995008 Free PMC article.
A secondary metabolite of Brassicales, 1-methoxy-3-indolylmethyl glucosinolate, as well as its degradation product, 1-methoxy-3-indolylmethyl alcohol, forms DNA adducts in the mouse, but in varying tissues and cells.
Schumacher F, Florian S, Schnapper A, Monien BH, Mewis I, Schreiner M, Seidel A, Engst W, Glatt H. Schumacher F, et al. Among authors: seidel a. Arch Toxicol. 2014 Mar;88(3):823-36. doi: 10.1007/s00204-013-1149-7. Epub 2013 Oct 24. Arch Toxicol. 2014. PMID: 24154822
495 results