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Cardiac Resynchronization Therapy Reduces Subcellular Heterogeneity of Ryanodine Receptors, T-Tubules, and Ca2+ Sparks Produced by Dyssynchronous Heart Failure.
Li H, Lichter JG, Seidel T, Tomaselli GF, Bridge JH, Sachse FB. Li H, et al. Among authors: Seidel T. Circ Heart Fail. 2015 Nov;8(6):1105-14. doi: 10.1161/CIRCHEARTFAILURE.115.002352. Epub 2015 Aug 20. Circ Heart Fail. 2015. PMID: 26294422 Free PMC article.
In anterior left ventricular cardiomyocytes, however, we found a similar degree of heterogeneous RyR remodeling, despite preserved t-system. ...RyR remodeling occurred in lateral and anterior cardiomyocytes, but remodeling of t-system was confined to lateral myocytes. ...
In anterior left ventricular cardiomyocytes, however, we found a similar degree of heterogeneous RyR remodeling, despite preserved t- …
Increased Susceptibility to Atrial Fibrillation Secondary to Atrial Fibrosis in Transgenic Goats Expressing Transforming Growth Factor-β1.
Polejaeva IA, Ranjan R, Davies CJ, Regouski M, Hall J, Olsen AL, Meng Q, Rutigliano HM, Dosdall DJ, Angel NA, Sachse FB, Seidel T, Thomas AJ, Stott R, Panter KE, Lee PM, Van Wettere AJ, Stevens JR, Wang Z, MacLeod RS, Marrouche NF, White KL. Polejaeva IA, et al. Among authors: Seidel T. J Cardiovasc Electrophysiol. 2016 Oct;27(10):1220-1229. doi: 10.1111/jce.13049. Epub 2016 Aug 30. J Cardiovasc Electrophysiol. 2016. PMID: 27447370 Free PMC article.
Diffusion tensor imaging and histology of developing hearts.
Abdullah OM, Seidel T, Dahl M, Gomez AD, Yiep G, Cortino J, Sachse FB, Albertine KH, Hsu EW. Abdullah OM, et al. Among authors: Seidel T. NMR Biomed. 2016 Oct;29(10):1338-49. doi: 10.1002/nbm.3576. Epub 2016 Aug 3. NMR Biomed. 2016. PMID: 27485033 Free PMC article.
Sheet-Like Remodeling of the Transverse Tubular System in Human Heart Failure Impairs Excitation-Contraction Coupling and Functional Recovery by Mechanical Unloading.
Seidel T, Navankasattusas S, Ahmad A, Diakos NA, Xu WD, Tristani-Firouzi M, Bonios MJ, Taleb I, Li DY, Selzman CH, Drakos SG, Sachse FB. Seidel T, et al. Circulation. 2017 Apr 25;135(17):1632-1645. doi: 10.1161/CIRCULATIONAHA.116.024470. Epub 2017 Jan 10. Circulation. 2017. PMID: 28073805 Free PMC article.
Hallmarks of HF are depletion and disorganization of the transverse tubular system (t-system) in cardiomyocytes. Here, we investigated remodeling of the t-system in human end-stage HF and its role in cardiac recovery. ...Three-dimensional confocal microscopy and computational image analysis were applied to assess t-system structure, density, and distance of ryanodine receptor clusters to the sarcolemma, including the t-system. ...
Hallmarks of HF are depletion and disorganization of the transverse tubular system (t-system) in cardiomyocytes. Here, we investigate …
Remodeling of the transverse tubular system after myocardial infarction in rabbit correlates with local fibrosis: A potential role of biomechanics.
Seidel T, Sankarankutty AC, Sachse FB. Seidel T, et al. Prog Biophys Mol Biol. 2017 Nov;130(Pt B):302-314. doi: 10.1016/j.pbiomolbio.2017.07.006. Epub 2017 Jul 11. Prog Biophys Mol Biol. 2017. PMID: 28709857 Free PMC article.
In cardiac diseases, such as heart failure, remodeling of the t-system contributes to reduced cardiac contractility. However, mechanisms of t-system remodeling are incompletely understood. ...Thus, locally altered tissue mechanics may contribute to t-system remodeling....
In cardiac diseases, such as heart failure, remodeling of the t-system contributes to reduced cardiac contractility. However, mechani …
On the role of the gap junction protein Cx43 (GJA1) in human cardiac malformations with Fallot-pathology. a study on paediatric cardiac specimen.
Salameh A, Haunschild J, Bräuchle P, Peim O, Seidel T, Reitmann M, Kostelka M, Bakhtiary F, Dhein S, Dähnert I. Salameh A, et al. Among authors: Seidel T. PLoS One. 2014 Apr 21;9(4):e95344. doi: 10.1371/journal.pone.0095344. eCollection 2014. PLoS One. 2014. PMID: 24751918 Free PMC article.
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