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Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes.
Kessler JH, Khan S, Seifert U, Le Gall S, Chow KM, Paschen A, Bres-Vloemans SA, de Ru A, van Montfoort N, Franken KL, Benckhuijsen WE, Brooks JM, van Hall T, Ray K, Mulder A, Doxiadis II, van Swieten PF, Overkleeft HS, Prat A, Tomkinson B, Neefjes J, Kloetzel PM, Rodgers DW, Hersh LB, Drijfhout JW, van Veelen PA, Ossendorp F, Melief CJ. Kessler JH, et al. Among authors: seifert u. Nat Immunol. 2011 Jan;12(1):45-53. doi: 10.1038/ni.1974. Epub 2010 Dec 12. Nat Immunol. 2011. PMID: 21151101
An essential role for tripeptidyl peptidase in the generation of an MHC class I epitope.
Seifert U, Marañón C, Shmueli A, Desoutter JF, Wesoloski L, Janek K, Henklein P, Diescher S, Andrieu M, de la Salle H, Weinschenk T, Schild H, Laderach D, Galy A, Haas G, Kloetzel PM, Reiss Y, Hosmalin A. Seifert U, et al. Nat Immunol. 2003 Apr;4(4):375-9. doi: 10.1038/ni905. Epub 2003 Feb 24. Nat Immunol. 2003. PMID: 12598896
Immunoproteasome LMP2 60HH variant alters MBP epitope generation and reduces the risk to develop multiple sclerosis in Italian female population.
Mishto M, Bellavista E, Ligorio C, Textoris-Taube K, Santoro A, Giordano M, D'Alfonso S, Listì F, Nacmias B, Cellini E, Leone M, Grimaldi LM, Fenoglio C, Esposito F, Martinelli-Boneschi F, Galimberti D, Scarpini E, Seifert U, Amato MP, Caruso C, Foschini MP, Kloetzel PM, Franceschi C. Mishto M, et al. Among authors: seifert u. PLoS One. 2010 Feb 18;5(2):e9287. doi: 10.1371/journal.pone.0009287. PLoS One. 2010. PMID: 20174631 Free PMC article.
The efficiency of human cytomegalovirus pp65(495-503) CD8+ T cell epitope generation is determined by the balanced activities of cytosolic and endoplasmic reticulum-resident peptidases.
Urban S, Textoris-Taube K, Reimann B, Janek K, Dannenberg T, Ebstein F, Seifert C, Zhao F, Kessler JH, Halenius A, Henklein P, Paschke J, Cadel S, Bernhard H, Ossendorp F, Foulon T, Schadendorf D, Paschen A, Seifert U. Urban S, et al. Among authors: seifert u, seifert c. J Immunol. 2012 Jul 15;189(2):529-38. doi: 10.4049/jimmunol.1101886. Epub 2012 Jun 15. J Immunol. 2012. PMID: 22706083
The proteasome immunosubunits, PA28 and ER-aminopeptidase 1 protect melanoma cells from efficient MART-126-35 -specific T-cell recognition.
Keller M, Ebstein F, Bürger E, Textoris-Taube K, Gorny X, Urban S, Zhao F, Dannenberg T, Sucker A, Keller C, Saveanu L, Krüger E, Rothkötter HJ, Dahlmann B, Henklein P, Voigt A, Kuckelkorn U, Paschen A, Kloetzel PM, Seifert U. Keller M, et al. Among authors: seifert u. Eur J Immunol. 2015 Dec;45(12):3257-68. doi: 10.1002/eji.201445243. Epub 2015 Oct 19. Eur J Immunol. 2015. PMID: 26399368 Free article.
227 results