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Different activation domains stimulate transcription from remote ('enhancer') and proximal ('promoter') positions.
Seipel K, Georgiev O, Schaffner W. Seipel K, et al. EMBO J. 1992 Dec;11(13):4961-8. EMBO J. 1992. PMID: 1464321 Free PMC article.
Functional interplay of SP family members and nuclear factor Y is essential for transcriptional activation of the human Calreticulin gene.
Schardt JA, Keller M, Seipel K, Pabst T. Schardt JA, et al. Among authors: seipel k. Biochim Biophys Acta. 2015 Sep;1849(9):1188-97. doi: 10.1016/j.bbagrm.2015.07.003. Epub 2015 Jul 8. Biochim Biophys Acta. 2015. PMID: 26162987
Transcriptional activation modulated by homopolymeric glutamine and proline stretches.
Gerber HP, Seipel K, Georgiev O, Höfferer M, Hug M, Rusconi S, Schaffner W. Gerber HP, et al. Among authors: seipel k. Science. 1994 Feb 11;263(5148):808-11. doi: 10.1126/science.8303297. Science. 1994. PMID: 8303297
C-terminal domain (CTD) of RNA-polymerase II and N-terminal segment of the human TATA binding protein (TBP) can mediate remote and proximal transcriptional activation, respectively.
Seipel K, Georgiev O, Gerber HP, Schaffner W. Seipel K, et al. Nucleic Acids Res. 1993 Dec 11;21(24):5609-15. doi: 10.1093/nar/21.24.5609. Nucleic Acids Res. 1993. PMID: 8284205 Free PMC article.
A minimal transcription activation domain consisting of a specific array of aspartic acid and leucine residues.
Seipel K, Georgiev O, Schaffner W. Seipel K, et al. Biol Chem Hoppe Seyler. 1994 Jul;375(7):463-70. doi: 10.1515/bchm3.1994.375.7.463. Biol Chem Hoppe Seyler. 1994. PMID: 7945996
Different potential of cellular and viral activators of transcription revealed in oocytes and early embryos of Xenopus laevis.
Xu L, Rungger D, Georgiev O, Seipel K, Schaffner W. Xu L, et al. Among authors: seipel k. Biol Chem Hoppe Seyler. 1994 Feb;375(2):105-12. doi: 10.1515/bchm3.1994.375.2.105. Biol Chem Hoppe Seyler. 1994. PMID: 8192855
Functional differences between mammalian transcription activation domains at the yeast GAL1 promoter.
Künzler M, Braus GH, Georgiev O, Seipel K, Schaffner W. Künzler M, et al. Among authors: seipel k. EMBO J. 1994 Feb 1;13(3):641-5. EMBO J. 1994. PMID: 8313909 Free PMC article.
Basal components of the transcription apparatus (RNA polymerase II, TATA-binding protein) contain activation domains: is the repetitive C-terminal domain (CTD) of RNA polymerase II a "portable enhancer domain"?
Seipel K, Georgiev O, Gerber HP, Schaffner W. Seipel K, et al. Mol Reprod Dev. 1994 Oct;39(2):215-25. doi: 10.1002/mrd.1080390215. Mol Reprod Dev. 1994. PMID: 7826625
RNA polymerase II C-terminal domain required for enhancer-driven transcription.
Gerber HP, Hagmann M, Seipel K, Georgiev O, West MA, Litingtung Y, Schaffner W, Corden JL. Gerber HP, et al. Among authors: seipel k. Nature. 1995 Apr 13;374(6523):660-2. doi: 10.1038/374660a0. Nature. 1995. PMID: 7715709
Promoters with the octamer DNA motif (ATGCAAAT) can be ubiquitous or cell type-specific depending on binding affinity of the octamer site and Oct-factor concentration.
Kemler I, Bucher E, Seipel K, Müller-Immerglück MM, Schaffner W. Kemler I, et al. Among authors: seipel k. Nucleic Acids Res. 1991 Jan 25;19(2):237-42. doi: 10.1093/nar/19.2.237. Nucleic Acids Res. 1991. PMID: 2014164 Free PMC article.
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