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EUCOMM--the European conditional mouse mutagenesis program.
Friedel RH, Seisenberger C, Kaloff C, Wurst W. Friedel RH, et al. Among authors: seisenberger c. Brief Funct Genomic Proteomic. 2007 Sep;6(3):180-5. doi: 10.1093/bfgp/elm022. Epub 2007 Oct 29. Brief Funct Genomic Proteomic. 2007. PMID: 17967808
Genomewide production of multipurpose alleles for the functional analysis of the mouse genome.
Schnütgen F, De-Zolt S, Van Sloun P, Hollatz M, Floss T, Hansen J, Altschmied J, Seisenberger C, Ghyselinck NB, Ruiz P, Chambon P, Wurst W, von Melchner H. Schnütgen F, et al. Proc Natl Acad Sci U S A. 2005 May 17;102(20):7221-6. doi: 10.1073/pnas.0502273102. Epub 2005 May 3. Proc Natl Acad Sci U S A. 2005. PMID: 15870191 Free PMC article.
CRISPR-Cas9 enables conditional mutagenesis of challenging loci.
Schick JA, Seisenberger C, Beig J, Bürger A, Iyer V, Maier V, Perera S, Rosen B, Skarnes WC, Wurst W. Schick JA, et al. Among authors: seisenberger c. Sci Rep. 2016 Sep 1;6:32326. doi: 10.1038/srep32326. Sci Rep. 2016. PMID: 27580957 Free PMC article.
High-throughput trapping of secretory pathway genes in mouse embryonic stem cells.
De-Zolt S, Schnütgen F, Seisenberger C, Hansen J, Hollatz M, Floss T, Ruiz P, Wurst W, von Melchner H. De-Zolt S, et al. Among authors: seisenberger c. Nucleic Acids Res. 2006 Feb 13;34(3):e25. doi: 10.1093/nar/gnj026. Nucleic Acids Res. 2006. PMID: 16478711 Free PMC article.
The mammalian gene function resource: the International Knockout Mouse Consortium.
Bradley A, Anastassiadis K, Ayadi A, Battey JF, Bell C, Birling MC, Bottomley J, Brown SD, Bürger A, Bult CJ, Bushell W, Collins FS, Desaintes C, Doe B, Economides A, Eppig JT, Finnell RH, Fletcher C, Fray M, Frendewey D, Friedel RH, Grosveld FG, Hansen J, Hérault Y, Hicks G, Hörlein A, Houghton R, Hrabé de Angelis M, Huylebroeck D, Iyer V, de Jong PJ, Kadin JA, Kaloff C, Kennedy K, Koutsourakis M, Lloyd KC, Marschall S, Mason J, McKerlie C, McLeod MP, von Melchner H, Moore M, Mujica AO, Nagy A, Nefedov M, Nutter LM, Pavlovic G, Peterson JL, Pollock J, Ramirez-Solis R, Rancourt DE, Raspa M, Remacle JE, Ringwald M, Rosen B, Rosenthal N, Rossant J, Ruiz Noppinger P, Ryder E, Schick JZ, Schnütgen F, Schofield P, Seisenberger C, Selloum M, Simpson EM, Skarnes WC, Smedley D, Stanford WL, Stewart AF, Stone K, Swan K, Tadepally H, Teboul L, Tocchini-Valentini GP, Valenzuela D, West AP, Yamamura K, Yoshinaga Y, Wurst W. Bradley A, et al. Among authors: seisenberger c. Mamm Genome. 2012 Oct;23(9-10):580-6. doi: 10.1007/s00335-012-9422-2. Epub 2012 Sep 12. Mamm Genome. 2012. PMID: 22968824 Free PMC article.
Functional embryonic cardiomyocytes after disruption of the L-type alpha1C (Cav1.2) calcium channel gene in the mouse.
Seisenberger C, Specht V, Welling A, Platzer J, Pfeifer A, Kühbandner S, Striessnig J, Klugbauer N, Feil R, Hofmann F. Seisenberger C, et al. J Biol Chem. 2000 Dec 15;275(50):39193-9. doi: 10.1074/jbc.M006467200. J Biol Chem. 2000. PMID: 10973973
Homozygous knockout embryos (Ca(v)1. 2-/-) died before day 14.5 postcoitum (p.c.). At day 12.5 p.c., the embryonic heart contracted with identical frequency in wild type (+/+), heterozygous (+/-), and homozygous (-/-) Ca(v)1.2 embryos. ...The low affinity I(Ba) was …
Homozygous knockout embryos (Ca(v)1. 2-/-) died before day 14.5 postcoitum (p.c.). At day 12.5 p.c., the embryonic heart contr …
L-type Ca2+ channels of the embryonic mouse heart.
Klugbauer N, Welling A, Specht V, Seisenberger C, Hofmann F. Klugbauer N, et al. Eur J Pharmacol. 2002 Jul 5;447(2-3):279-84. doi: 10.1016/s0014-2999(02)01850-2. Eur J Pharmacol. 2002. PMID: 12151019 Review.
Mice with a homozygous deletion of the L-type Ca(v)1.2 Ca(2+) channel gene die before day 14.5 p.c. Electrophysiological and pharmacological investigations on Ca(v)1.2-/- cardiomyocytes demonstrated that contractions depended on the influx of Ca(2+) through an L-type-like …
Mice with a homozygous deletion of the L-type Ca(v)1.2 Ca(2+) channel gene die before day 14.5 p.c. Electrophysiological and pharmaco …
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