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Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial.
Kumar P, Liu C, Hsu JW, Chacko S, Minard C, Jahoor F, Sekhar RV. Kumar P, et al. Clin Transl Med. 2021 Mar;11(3):e372. doi: 10.1002/ctm2.372. Clin Transl Med. 2021. PMID: 33783984 Free PMC article.
BACKGROUND: Oxidative stress (OxS) and mitochondrial dysfunction are implicated as causative factors for aging. Older adults (OAs) have an increased prevalence of elevated OxS, impaired mitochondrial fuel-oxidation (MFO), elevated inflammation, endothelial dy …
BACKGROUND: Oxidative stress (OxS) and mitochondrial dysfunction are implicated as causative factors for aging. Older adult …
GlyNAC Supplementation Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Aging Hallmarks, Metabolic Defects, Muscle Strength, Cognitive Decline, and Body Composition: Implications for Healthy Aging.
Sekhar RV. Sekhar RV. J Nutr. 2021 Dec 3;151(12):3606-3616. doi: 10.1093/jn/nxab309. J Nutr. 2021. PMID: 34587244 Free article. Review.
It is particularly exciting that GlyNAC supplementation appears to reverse multiple aging hallmarks, and if confirmed in a randomized clinical trial, it could introduce a transformative paradigm shift in aging and geriatrics. GlyNAC supplementation cou …
It is particularly exciting that GlyNAC supplementation appears to reverse multiple aging hallmarks, and if confirmed in a ran …