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Selective remediation of reversal learning deficits in the neurodevelopmental MAM model of schizophrenia by a novel mGlu5 positive allosteric modulator.
Gastambide F, Cotel MC, Gilmour G, O'Neill MJ, Robbins TW, Tricklebank MD. Gastambide F, et al. Neuropsychopharmacology. 2012 Mar;37(4):1057-66. doi: 10.1038/npp.2011.298. Epub 2011 Nov 30. Neuropsychopharmacology. 2012. PMID: 22129780 Free PMC article.
Results showed that LSN2463359 selectively attenuated reversal learning deficits in the MAM but not acute PCP model. Whilst both models led to deficits in reversal learning and extra-dimensional set-shifting, the reversal im …
Results showed that LSN2463359 selectively attenuated reversal learning deficits in the MAM but not acute PCP mo …
Auditory Training Reverses Lead (Pb)-Toxicity-Induced Changes in Sound-Azimuth Selectivity of Cortical Neurons.
Liu X, Wei F, Cheng Y, Zhang Y, Jia G, Zhou J, Zhu M, Shan Y, Sun X, Yu L, Merzenich MM, Lurie DI, Zheng Q, Zhou X. Liu X, et al. Cereb Cortex. 2019 Jul 22;29(8):3294-3304. doi: 10.1093/cercor/bhy199. Cereb Cortex. 2019. PMID: 30137254
This reversal of cortical spatial fidelity was paralleled by changes in cortical expression of certain excitatory and inhibitory neurotransmitter receptor subunits. ...They also indicate that attention-demanding auditory training may remediate lead-induced cortical …
This reversal of cortical spatial fidelity was paralleled by changes in cortical expression of certain excitatory and inhibitory neur …
Age-related changes in prefrontal norepinephrine transporter density: The basis for improved cognitive flexibility after low doses of atomoxetine in adolescent rats.
Bradshaw SE, Agster KL, Waterhouse BD, McGaughy JA. Bradshaw SE, et al. Brain Res. 2016 Jun 15;1641(Pt B):245-57. doi: 10.1016/j.brainres.2016.01.001. Epub 2016 Jan 14. Brain Res. 2016. PMID: 26774596 Free PMC article.
The current study uses an adolescent rat model to study the effect of standard ADHD treatments, atomoxetine and methylphenidate on attentional set shifting and reversal learning. While both of these drugs act as norepinephrine reuptake inhibitors, higher doses of at …
The current study uses an adolescent rat model to study the effect of standard ADHD treatments, atomoxetine and methylphenidate on attention …
Mindfulness as a potential intervention for stimulus over-selectivity in older adults.
McHugh L, Simpson A, Reed P. McHugh L, et al. Res Dev Disabil. 2010 Jan-Feb;31(1):178-84. doi: 10.1016/j.ridd.2009.08.009. Epub 2009 Oct 7. Res Dev Disabil. 2010. PMID: 19815376 Clinical Trial.
This effect can have a serious impact on the physical and psychological health of older adults as well as their quality of life. One phenomenon linked to cognitive deficits, particularly attention, that has been demonstrated to emerge with ageing is over-selectivity
This effect can have a serious impact on the physical and psychological health of older adults as well as their quality of life. One phenome …