Selkoe D - Search Results

1

A new method for quantitative immunoblotting of endogenous α-synuclein.

Newman AJ, Selkoe D, Dettmer U. Newman AJ, et al. Among authors: selkoe d. PLoS One. 2013 Nov 20;8(11):e81314. doi: 10.1371/journal.pone.0081314. eCollection 2013. PLoS One. 2013. PMID: 24278419 Free PMC article.

2

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease.

Shimura H, Schlossmacher MG, Hattori N, Frosch MP, Trockenbacher A, Schneider R, Mizuno Y, Kosik KS, Selkoe DJ. Shimura H, et al. Among authors: selkoe dj. Science. 2001 Jul 13;293(5528):263-9. doi: 10.1126/science.1060627. Epub 2001 Jun 28. Science. 2001. PMID: 11431533

3

alpha-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins.

Sharon R, Goldberg MS, Bar-Josef I, Betensky RA, Shen J, Selkoe DJ. Sharon R, et al. Among authors: selkoe dj. Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9110-5. doi: 10.1073/pnas.171300598. Proc Natl Acad Sci U S A. 2001. PMID: 11481478 Free PMC article.

4

The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease.

Sharon R, Bar-Joseph I, Frosch MP, Walsh DM, Hamilton JA, Selkoe DJ. Sharon R, et al. Neuron. 2003 Feb 20;37(4):583-95. doi: 10.1016/s0896-6273(03)00024-2. Neuron. 2003. PMID: 12597857 Free article.

5

Altered fatty acid composition of dopaminergic neurons expressing alpha-synuclein and human brains with alpha-synucleinopathies.

Sharon R, Bar-Joseph I, Mirick GE, Serhan CN, Selkoe DJ. Sharon R, et al. J Biol Chem. 2003 Dec 12;278(50):49874-81. doi: 10.1074/jbc.M309127200. Epub 2003 Sep 23. J Biol Chem. 2003. PMID: 14507911 Free article.

6

Evidence that alpha-synuclein does not inhibit phospholipase D.

Rappley I, Gitler AD, Selvy PE, LaVoie MJ, Levy BD, Brown HA, Lindquist S, Selkoe DJ. Rappley I, et al. Among authors: selkoe dj. Biochemistry. 2009 Feb 10;48(5):1077-83. doi: 10.1021/bi801871h. Biochemistry. 2009. PMID: 19146388 Free PMC article.

7

Lipidomic profiling in mouse brain reveals differences between ages and genders, with smaller changes associated with alpha-synuclein genotype.

Rappley I, Myers DS, Milne SB, Ivanova PT, Lavoie MJ, Brown HA, Selkoe DJ. Rappley I, et al. J Neurochem. 2009 Oct;111(1):15-25. doi: 10.1111/j.1471-4159.2009.06290.x. Epub 2009 Jul 17. J Neurochem. 2009. PMID: 19627450 Free PMC article.

8

Identification of beta-secretase (BACE1) substrates using quantitative proteomics.

Hemming ML, Elias JE, Gygi SP, Selkoe DJ. Hemming ML, et al. PLoS One. 2009 Dec 29;4(12):e8477. doi: 10.1371/journal.pone.0008477. PLoS One. 2009. PMID: 20041192 Free PMC article.

9

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation.

Bartels T, Choi JG, Selkoe DJ. Bartels T, et al. Nature. 2011 Aug 14;477(7362):107-10. doi: 10.1038/nature10324. Nature. 2011. PMID: 21841800 Free PMC article.

10

In vivo cross-linking reveals principally oligomeric forms of α-synuclein and β-synuclein in neurons and non-neural cells.

Dettmer U, Newman AJ, Luth ES, Bartels T, Selkoe D. Dettmer U, et al. Among authors: selkoe d. J Biol Chem. 2013 Mar 1;288(9):6371-85. doi: 10.1074/jbc.M112.403311. Epub 2013 Jan 14. J Biol Chem. 2013. PMID: 23319586 Free PMC article.

We recently reported that alphaSyn can instead exist in cells as a helically folded tetramer that resists aggregation and binds lipid vesicles more avidly than unfolded recombinant monomers (Bartels, T., Choi, J. G., and Selkoe, D. J. (2011) Nature 477, 107-110). Ho …

We recently reported that alphaSyn can instead exist in cells as a helically folded tetramer that resists aggregation and binds lipid vesicl …

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