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226 results

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Page 1
Semax peptide targets the mu opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice.
Liu R, Chen Y, Huang H, Li X, Lv J, Jiang L, Jiang H, Wu C, Chen W, Xu H, Zhu Z, Cai H, Xiao J, Yin L, Ni W. Liu R, et al. Br J Pharmacol. 2025 Nov;182(22):5489-5516. doi: 10.1111/bph.70122. Epub 2025 Jul 21. Br J Pharmacol. 2025. PMID: 40692165
RNA sequencing, network pharmacology and molecular docking were used to identify possible molecular targets of Semax. KEY RESULTS: Semax improved SCI functional recovery and inhibited LMP-related pyroptosis in SCI mice and neuroinflammation models, by decreasing oxi …
RNA sequencing, network pharmacology and molecular docking were used to identify possible molecular targets of Semax. KEY RESULTS: …
Semax, synthetic ACTH(4-10) analogue, attenuates behavioural and neurochemical alterations following early-life fluvoxamine exposure in white rats.
Glazova NY, Manchenko DM, Volodina MA, Merchieva SA, Andreeva LA, Kudrin VS, Myasoedov NF, Levitskaya NG. Glazova NY, et al. Neuropeptides. 2021 Apr;86:102114. doi: 10.1016/j.npep.2020.102114. Epub 2020 Dec 28. Neuropeptides. 2021. PMID: 33418449
After FA treatment, rats were administered with Semax or vehicle on postnatal days 15-28. During the 2nd month of life, the rats underwent behavioural testing, and monoamine levels in brain structures were measured. ...Thus, peptide Semax can prevent behavioural def …
After FA treatment, rats were administered with Semax or vehicle on postnatal days 15-28. During the 2nd month of life, the rats unde …
Semax, a Synthetic Regulatory Peptide, Affects Copper-Induced Abeta Aggregation and Amyloid Formation in Artificial Membrane Models.
Sciacca MFM, Naletova I, Giuffrida ML, Attanasio F. Sciacca MFM, et al. ACS Chem Neurosci. 2022 Feb 16;13(4):486-496. doi: 10.1021/acschemneuro.1c00707. Epub 2022 Jan 26. ACS Chem Neurosci. 2022. PMID: 35080861 Free PMC article.
Here we tested the anti-aggregating properties of a heptapeptide, Semax, an ACTH-like peptide, which is known to form a stable complex with Cu(2+) ions and has been proven to have neuroprotective and nootropic effects. ...The results suggest that Semax inhibits fibe …
Here we tested the anti-aggregating properties of a heptapeptide, Semax, an ACTH-like peptide, which is known to form a stable comple …
Effects of Semax on the Default Mode Network of the Brain.
Lebedeva IS, Panikratova YR, Sokolov OY, Kupriyanov DA, Rumshiskaya AD, Kost NV, Myasoedov NF. Lebedeva IS, et al. Bull Exp Biol Med. 2018 Sep;165(5):653-656. doi: 10.1007/s10517-018-4234-3. Epub 2018 Sep 17. Bull Exp Biol Med. 2018. PMID: 30225715
The effects of nootropic drug Semax on the neuronal network of the brain were studied by the resting state functional magnetic-resonance imaging (resting state fMRI). ...A greater volume of the default mode network rostral (medial frontal cortex) subcomponent was detected …
The effects of nootropic drug Semax on the neuronal network of the brain were studied by the resting state functional magnetic-resona …
Semax, an analog of ACTH((4-7)), regulates expression of immune response genes during ischemic brain injury in rats.
Medvedeva EV, Dmitrieva VG, Limborska SA, Myasoedov NF, Dergunova LV. Medvedeva EV, et al. Mol Genet Genomics. 2017 Jun;292(3):635-653. doi: 10.1007/s00438-017-1297-1. Epub 2017 Mar 2. Mol Genet Genomics. 2017. PMID: 28255762
We suppose that neuroprotective mechanism of Semax is realized via the neuroimmune crosstalk, and the new properties of PGP were found under ischemia. Our results provided the basis for further proteomic investigations in the field of searching Semax neuroprotection …
We suppose that neuroprotective mechanism of Semax is realized via the neuroimmune crosstalk, and the new properties of PGP were foun …
Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia.
Dmitrieva VG, Povarova OV, Skvortsova VI, Limborska SA, Myasoedov NF, Dergunova LV. Dmitrieva VG, et al. Cell Mol Neurobiol. 2010 Jan;30(1):71-9. doi: 10.1007/s10571-009-9432-0. Epub 2009 Jul 25. Cell Mol Neurobiol. 2010. PMID: 19633950 Free PMC article.
Consisting of a fragment of ACTH(4-7) and C-terminal PGP tripeptide, the polypeptide Semax is successfully used for acute stroke therapy. Previous experiments showed rapid induction of Bdnf, Ngf, and TrkB expression in intact rat hippocampus following Semax treatmen …
Consisting of a fragment of ACTH(4-7) and C-terminal PGP tripeptide, the polypeptide Semax is successfully used for acute stroke ther …
Functional Connectomic Approach to Studying Selank and Semax Effects.
Panikratova YR, Lebedeva IS, Sokolov OY, Rumshiskaya AD, Kupriyanov DA, Kost NV, Myasoedov NF. Panikratova YR, et al. Dokl Biol Sci. 2020 Jan;490(1):9-11. doi: 10.1134/S001249662001007X. Epub 2020 Apr 27. Dokl Biol Sci. 2020. PMID: 32342318
The present study was aimed at the assessment of effects of anxiolytic Selank and nootropic Semax on the whole-brain resting-state functional connectivity (FC) of each of the predefined regions of interest (ROIs) in 52 healthy participants. ...Post hoc analysis allowed us …
The present study was aimed at the assessment of effects of anxiolytic Selank and nootropic Semax on the whole-brain resting-state fu …
Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents.
Eremin KO, Kudrin VS, Saransaari P, Oja SS, Grivennikov IA, Myasoedov NF, Rayevsky KS. Eremin KO, et al. Neurochem Res. 2005 Dec;30(12):1493-500. doi: 10.1007/s11064-005-8826-8. Neurochem Res. 2005. PMID: 16362768
The tissue content of 5-hydroxyindoleacetic acid (5-HIAA) in the striatum was significantly increased (+25%) 2 h after Semax administration. The extracellular striatal level of 5-HIAA gradually increased up to 180% within 1-4 h after Semax (0.15 mg/kg, ip) administr …
The tissue content of 5-hydroxyindoleacetic acid (5-HIAA) in the striatum was significantly increased (+25%) 2 h after Semax administ …
Semax, an analogue of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain.
Dolotov OV, Karpenko EA, Seredenina TS, Inozemtseva LS, Levitskaya NG, Zolotarev YA, Kamensky AA, Grivennikov IA, Engele J, Myasoedov NF. Dolotov OV, et al. J Neurochem. 2006 Apr;97 Suppl 1:82-6. doi: 10.1111/j.1471-4159.2006.03658.x. J Neurochem. 2006. PMID: 16635254 Free article.
In addition, we examined whether cell membranes isolated from this brain region contained binding sites for Semax. The binding of tritium-labelled Semax was found to be time dependent, specific and reversible. ...These results point to the presence of specific bindi …
In addition, we examined whether cell membranes isolated from this brain region contained binding sites for Semax. The binding of tri …
Semax, a Copper Chelator Peptide, Decreases the Cu(II)-Catalyzed ROS Production and Cytotoxicity of abeta by Metal Ion Stripping and Redox Silencing.
Tomasello MF, Di Rosa MC, Naletova I, Sciacca MFM, Giuffrida A, Maccarrone G, Attanasio F. Tomasello MF, et al. Bioinorg Chem Appl. 2025 Jun 3;2025:4226220. doi: 10.1155/bca/4226220. eCollection 2025. Bioinorg Chem Appl. 2025. PMID: 40496623 Free PMC article.
The ability of the peptide Semax to inhibit the copper-catalyzed oxidation of abeta was studied in vitro and discussed. ...Finally, our data suggest that Semax shows cytoprotective properties for SH-SY5Y cells against oxidative stress induced by copper-catalyzed oxi …
The ability of the peptide Semax to inhibit the copper-catalyzed oxidation of abeta was studied in vitro and discussed. ...Finally, o …
226 results