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Did you mean emax acth fragment (2 results)?
Functional Connectomic Approach to Studying Selank and Semax Effects.
Panikratova YR, Lebedeva IS, Sokolov OY, Rumshiskaya AD, Kupriyanov DA, Kost NV, Myasoedov NF. Panikratova YR, et al. Dokl Biol Sci. 2020 Jan;490(1):9-11. doi: 10.1134/S001249662001007X. Epub 2020 Apr 27. Dokl Biol Sci. 2020. PMID: 32342318
The present study was aimed at the assessment of effects of anxiolytic Selank and nootropic Semax on the whole-brain resting-state functional connectivity (FC) of each of the predefined regions of interest (ROIs) in 52 healthy participants. ...Post hoc analysis allowed us …
The present study was aimed at the assessment of effects of anxiolytic Selank and nootropic Semax on the whole-brain resting-state fu …
Semax peptide targets the mu opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice.
Liu R, Chen Y, Huang H, Li X, Lv J, Jiang L, Jiang H, Wu C, Chen W, Xu H, Zhu Z, Cai H, Xiao J, Yin L, Ni W. Liu R, et al. Br J Pharmacol. 2025 Nov;182(22):5489-5516. doi: 10.1111/bph.70122. Epub 2025 Jul 21. Br J Pharmacol. 2025. PMID: 40692165
Ubiquitination may affect LMP by regulating the stability and functionality of lysosomal membranes. Semax, a synthetic heptapeptide, comprising the ACTH (4-7) fragment and a C-terminal Pro-Gly-Pro tripeptide, exhibits neuroprotective properties and improves c …
Ubiquitination may affect LMP by regulating the stability and functionality of lysosomal membranes. Semax, a synthetic heptapeptide, …
Semax, synthetic ACTH(4-10) analogue, attenuates behavioural and neurochemical alterations following early-life fluvoxamine exposure in white rats.
Glazova NY, Manchenko DM, Volodina MA, Merchieva SA, Andreeva LA, Kudrin VS, Myasoedov NF, Levitskaya NG. Glazova NY, et al. Neuropeptides. 2021 Apr;86:102114. doi: 10.1016/j.npep.2020.102114. Epub 2020 Dec 28. Neuropeptides. 2021. PMID: 33418449
The mechanisms of SSRI effects on developing brain remain largely unknown and there are no directional approaches for prevention of the consequences of maternal SSRI treatment during pregnancy. The heptapeptide Semax (MEHFPGP) is a synthetic analogue of ACTH(4-10) w …
The mechanisms of SSRI effects on developing brain remain largely unknown and there are no directional approaches for prevention of the cons …
Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents.
Eremin KO, Kudrin VS, Saransaari P, Oja SS, Grivennikov IA, Myasoedov NF, Rayevsky KS. Eremin KO, et al. Neurochem Res. 2005 Dec;30(12):1493-500. doi: 10.1007/s11064-005-8826-8. Neurochem Res. 2005. PMID: 16362768
Corticotrophin (ACTH) and its analogues, particularly Semax (Met-Glu-His-Phe-Pro-Gly-Pro), demonstrate nootropic activity. ...Our results reveal the positive modulatory effect of Semax on the striatal serotonergic system and the ability of Semax to enh …
Corticotrophin (ACTH) and its analogues, particularly Semax (Met-Glu-His-Phe-Pro-Gly-Pro), demonstrate nootropic activity. ... …
Semax, an analog of ACTH((4-7)), regulates expression of immune response genes during ischemic brain injury in rats.
Medvedeva EV, Dmitrieva VG, Limborska SA, Myasoedov NF, Dergunova LV. Medvedeva EV, et al. Mol Genet Genomics. 2017 Jun;292(3):635-653. doi: 10.1007/s00438-017-1297-1. Epub 2017 Mar 2. Mol Genet Genomics. 2017. PMID: 28255762
To build the effective strategies for stroke treatment it is necessary to understand the neuroprotective mechanisms that are able to prevent the ischemic injury. Consisting of the ACTH((4-7)) fragment and the tripeptide Pro-Gly-Pro (PGP), the synthetic peptide Se …
To build the effective strategies for stroke treatment it is necessary to understand the neuroprotective mechanisms that are able to prevent …
Influence of the N-terminus acetylation of Semax, a synthetic analog of ACTH(4-10), on copper(II) and zinc(II) coordination and biological properties.
Magrì A, Tabbì G, Giuffrida A, Pappalardo G, Satriano C, Naletova I, Nicoletti VG, Attanasio F. Magrì A, et al. J Inorg Biochem. 2016 Nov;164:59-69. doi: 10.1016/j.jinorgbio.2016.08.013. Epub 2016 Aug 27. J Inorg Biochem. 2016. PMID: 27586814
Semax is a heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) that encompasses the sequence 4-7 of N-terminal domain of the adrenocorticotropic hormone and a C-terminal Pro-Gly-Pro tripeptide. N-terminal amino group acetylation (Ac-Semax) modulates the chemica …
Semax is a heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) that encompasses the sequence 4-7 of N-terminal domain of the adrenocorticot …
Antidepressant-like and antistress effects of the ACTH(4-10) synthetic analogs Semax and Melanotan II on male rats in a model of chronic unpredictable stress.
Inozemtseva LS, Yatsenko KA, Glazova NY, Kamensky AA, Myasoedov NF, Levitskaya NG, Grivennikov IA, Dolotov OV. Inozemtseva LS, et al. Eur J Pharmacol. 2024 Dec 5;984:177068. doi: 10.1016/j.ejphar.2024.177068. Epub 2024 Oct 21. Eur J Pharmacol. 2024. PMID: 39442746
HPA axis activity is self-regulated by negative feedback at several levels including adrenocorticotropic hormone (ACTH)-mediated feedback. Here, we investigated whether noncorticotropic synthetic analogs of the ACTH(4-10) fragment, ACTH( …
HPA axis activity is self-regulated by negative feedback at several levels including adrenocorticotropic hormone (ACTH) …
The Effect of Peptide Semax, an ACTH(4-10) Analogue, on Intracellular Calcium Dynamics in Rat Brain Neurons.
Kolbaev SN, Sharonova IN, Skrebitsky VG. Kolbaev SN, et al. Bull Exp Biol Med. 2025 Aug;179(4):416-420. doi: 10.1007/s10517-025-06501-z. Epub 2025 Oct 31. Bull Exp Biol Med. 2025. PMID: 41171324
We studied the effects of Semax on spontaneous fluctuations of intracellular calcium ion concentration [Ca(2+)](i) in pyramidal neurons on hippocampal slices and on proton-induced increase in [Ca(2+)](i) in cerebellar granule cells in cerebellar slices. ...The primary mech …
We studied the effects of Semax on spontaneous fluctuations of intracellular calcium ion concentration [Ca(2+)](i) in pyramidal neuro …
Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus.
Dolotov OV, Karpenko EA, Inozemtseva LS, Seredenina TS, Levitskaya NG, Rozyczka J, Dubynina EV, Novosadova EV, Andreeva LA, Alfeeva LY, Kamensky AA, Grivennikov IA, Myasoedov NF, Engele J. Dolotov OV, et al. Brain Res. 2006 Oct 30;1117(1):54-60. doi: 10.1016/j.brainres.2006.07.108. Epub 2006 Sep 22. Brain Res. 2006. PMID: 16996037
The heptapeptide Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is an analog of the adrenocorticotropin fragment (4-10) which after intranasal application has profound effects on learning and exerts marked neuroprotective activities. ...Semax-treated animals showed a di …
The heptapeptide Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is an analog of the adrenocorticotropin fragment (4-10) which after intra …
Novel Insights into the Protective Properties of ACTH((4-7))PGP (Semax) Peptide at the Transcriptome Level Following Cerebral Ischaemia-Reperfusion in Rats.
Filippenkov IB, Stavchansky VV, Denisova AE, Yuzhakov VV, Sevan'kaeva LE, Sudarkina OY, Dmitrieva VG, Gubsky LV, Myasoedov NF, Limborska SA, Dergunova LV. Filippenkov IB, et al. Genes (Basel). 2020 Jun 22;11(6):681. doi: 10.3390/genes11060681. Genes (Basel). 2020. PMID: 32580520 Free PMC article.
Biologically active peptides represent potential drugs for reducing the damage that occurs after ischaemia. The synthetic melanocortin derivative, ACTH((4-7))PGP (Semax), has been used successfully in the treatment of patients with severe impairment of cerebral bloo …
Biologically active peptides represent potential drugs for reducing the damage that occurs after ischaemia. The synthetic melanocortin deriv …
184 results