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Matrix elasticity directs stem cell lineage specification.
Engler AJ, Sen S, Sweeney HL, Discher DE. Engler AJ, et al. Cell. 2006 Aug 25;126(4):677-89. doi: 10.1016/j.cell.2006.06.044. Cell. 2006. PMID: 16923388
Upregulation of paxillin and focal adhesion signaling follows Dystroglycan Complex deletions and promotes a hypertensive state of differentiation.
Sen S, Tewari M, Zajac A, Barton E, Sweeney HL, Discher DE. Sen S, et al. Eur J Cell Biol. 2011 Feb-Mar;90(2-3):249-60. doi: 10.1016/j.ejcb.2010.06.005. Eur J Cell Biol. 2011. PMID: 20663583 Free PMC article.
Matrix strains induced by cells: Computing how far cells can feel.
Sen S, Engler AJ, Discher DE. Sen S, et al. Cell Mol Bioeng. 2009 Mar 1;2(1):39-48. doi: 10.1007/s12195-009-0052-z. Cell Mol Bioeng. 2009. PMID: 20582230 Free PMC article.
Species- and cell type-specific interactions between CD47 and human SIRPalpha.
Subramanian S, Parthasarathy R, Sen S, Boder ET, Discher DE. Subramanian S, et al. Blood. 2006 Mar 15;107(6):2548-56. doi: 10.1182/blood-2005-04-1463. Epub 2005 Nov 15. Blood. 2006. PMID: 16291597 Free PMC article.
Myotubes differentiate optimally on substrates with tissue-like stiffness: pathological implications for soft or stiff microenvironments.
Engler AJ, Griffin MA, Sen S, Bönnemann CG, Sweeney HL, Discher DE. Engler AJ, et al. J Cell Biol. 2004 Sep 13;166(6):877-87. doi: 10.1083/jcb.200405004. J Cell Biol. 2004. PMID: 15364962 Free PMC article.
However, myosin/actin striations emerge later only on gels with stiffness typical of normal muscle (passive Young's modulus, E approximately 12 kPa). ...
However, myosin/actin striations emerge later only on gels with stiffness typical of normal muscle (passive Young's modulus, E approx …
Adhesion-contractile balance in myocyte differentiation.
Griffin MA, Sen S, Sweeney HL, Discher DE. Griffin MA, et al. J Cell Sci. 2004 Nov 15;117(Pt 24):5855-63. doi: 10.1242/jcs.01496. Epub 2004 Nov 2. J Cell Sci. 2004. PMID: 15522893
Polymersome delivery of siRNA and antisense oligonucleotides.
Kim Y, Tewari M, Pajerowski JD, Cai S, Sen S, Williams JH, Sirsi SR, Lutz GJ, Discher DE. Kim Y, et al. J Control Release. 2009 Mar 4;134(2):132-40. doi: 10.1016/j.jconrel.2008.10.020. Epub 2008 Nov 12. J Control Release. 2009. PMID: 19084037 Free PMC article.
Membrane mobility and clustering of Integrin Associated Protein (IAP, CD47)--major differences between mouse and man and implications for signaling.
Subramanian S, Tsai R, Sen S, Dahl KN, Discher DE. Subramanian S, et al. Blood Cells Mol Dis. 2006 May-Jun;36(3):364-72. doi: 10.1016/j.bcmd.2006.01.012. Epub 2006 May 11. Blood Cells Mol Dis. 2006. PMID: 16697668
SIRPalpha is CD47's main receptor on phagocytes plus a number of other cell types, and SIRPalpha-CD47 interactions in clusters are believed to mediate signaling. ...
SIRPalpha is CD47's main receptor on phagocytes plus a number of other cell types, and SIRPalpha-CD47 interactions in clusters are be …
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