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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1947 1
1948 2
1949 3
1950 3
1951 9
1952 2
1953 1
1954 2
1955 2
1957 10
1958 5
1959 2
1960 7
1961 7
1962 5
1963 12
1964 10
1965 9
1968 3
1969 1
1970 2
1971 1
1972 3
1973 2
1974 1
1975 1
1976 1
1978 3
1979 3
1980 8
1981 8
1982 7
1983 4
1984 4
1985 7
1986 4
1987 6
1988 24
1989 6
1990 4
1991 5
1992 6
1993 25
1994 3
1995 8
1996 8
1997 1
1998 7
1999 8
2000 10
2001 8
2002 5
2003 3
2004 11
2005 6
2006 13
2007 8
2008 12
2009 8
2010 8
2011 11
2012 11
2013 15
2014 15
2015 17
2016 17
2017 11
2018 14
2019 20
2020 25
2021 26
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514 results
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Page 1
Sennoside A drug capped biogenic fabrication of silver nanoparticles and their antibacterial and antifungal activities.
Al-Ghamdi AD, Zaheer Z, Aazam ES. Al-Ghamdi AD, et al. Saudi Pharm J. 2020 Aug;28(8):1035-1048. doi: 10.1016/j.jsps.2020.07.003. Epub 2020 Jul 6. Saudi Pharm J. 2020. PMID: 32792848 Free PMC article.
Sennoside A capped silver nanoparticles (Ag/sennoside A) were synthesized at room temperature for the first time by using sennoside A as reducing and capping agent. UV-visible spectroscopic data reveals that the absorption peaks of pure sennoside A was
Sennoside A capped silver nanoparticles (Ag/sennoside A) were synthesized at room temperature for the first time by using s
[Determination of sennoside B, sennoside A and physcion in slimming health foods].
Diao F, Xie Q, Wu X, Liu C, Li X, Li Q. Diao F, et al. Wei Sheng Yan Jiu. 2020 Sep;49(5):809-814. doi: 10.19813/j.cnki.weishengyanjiu.2020.05.020. Wei Sheng Yan Jiu. 2020. PMID: 33070828 Chinese.
Sennoside A, sennoside B or physcion were detected in 19 out of 40 batches of samples. ...CONCLUSION: The method is simple, accurate and suitable for the determination of sennoside A, sennoside B and physcion....
Sennoside A, sennoside B or physcion were detected in 19 out of 40 batches of samples. ...CONCLUSION: The method is simple, ac
Pharmacokinetic and metabolic profiling studies of sennoside B by UPLC-MS/MS and UPLC-Q-TOF-MS.
Wu H, Feng F, Jiang X, Hu B, Qiu J, Wang C, Xiang Z. Wu H, et al. J Pharm Biomed Anal. 2020 Feb 5;179:112938. doi: 10.1016/j.jpba.2019.112938. Epub 2019 Oct 21. J Pharm Biomed Anal. 2020. PMID: 31816471
Sennoside B is a specific dianthrone compound extracted from senna, which is widely used as a stimulant laxative but has potential side effects. This study aimed to obtain the metabolic and pharmacokinetic data of sennoside B. The metabolic profiles of sennoside
Sennoside B is a specific dianthrone compound extracted from senna, which is widely used as a stimulant laxative but has potential si
Gut Bacteria Selectively Altered by Sennoside A Alleviate Type 2 Diabetes and Obesity Traits.
Wei Z, Shen P, Cheng P, Lu Y, Wang A, Sun Z. Wei Z, et al. Oxid Med Cell Longev. 2020 Jun 25;2020:2375676. doi: 10.1155/2020/2375676. eCollection 2020. Oxid Med Cell Longev. 2020. PMID: 32685087 Free PMC article.
Here, we put forward the hypothesis that the structural alteration of gut microbiota in obesity mice may be involved in the pathogenesis of type 2 diabetes (T2D) which may be ameliorated by Sennoside A. We investigated the appearance of obesity, insulin resistance, host in …
Here, we put forward the hypothesis that the structural alteration of gut microbiota in obesity mice may be involved in the pathogenesis of …
Sennoside A Induces GLP-1 Secretion Through Activation of the ERK1/2 Pathway in L-Cells.
Ma L, Cao X, Ye X, Ye J, Sun Y. Ma L, et al. Diabetes Metab Syndr Obes. 2020 Apr 29;13:1407-1415. doi: 10.2147/DMSO.S247251. eCollection 2020. Diabetes Metab Syndr Obes. 2020. PMID: 32425572 Free PMC article.
PURPOSE: Glucagon-like peptide-1 (GLP-1) is secreted from the intestinal L-cells to stimulate insulin secretion in the blood glucose control. Our previous study indicates that Sennoside A (SA) can increase the plasma GLP-1 level in a mouse model of type 2 diabetes. ...
PURPOSE: Glucagon-like peptide-1 (GLP-1) is secreted from the intestinal L-cells to stimulate insulin secretion in the blood glucose control …
Sennoside A restores colonic barrier function through protecting colon enterocytes from ROS-induced mitochondrial damage in diet-induced obese mice.
Ma L, Cao X, Ye X, Qi Y, Zhu Y, Ye J, Sun Y. Ma L, et al. Biochem Biophys Res Commun. 2020 May 28;526(2):519-524. doi: 10.1016/j.bbrc.2020.03.117. Epub 2020 Mar 31. Biochem Biophys Res Commun. 2020. PMID: 32245617
It is generally believed that degradation of colon enterocytes contributes to intestinal barrier dysfunction in the pathological process of obesity. Sennoside A (SA) is reported to improve metabolic disorders, but the effect and mechanism of SA on colonic barrier function …
It is generally believed that degradation of colon enterocytes contributes to intestinal barrier dysfunction in the pathological process of …
Sennoside A prevents liver fibrosis by binding DNMT1 and suppressing DNMT1-mediated PTEN hypermethylation in HSC activation and proliferation.
Zhu H, He C, Zhao H, Jiang W, Xu S, Li J, Ma T, Huang C. Zhu H, et al. FASEB J. 2020 Nov;34(11):14558-14571. doi: 10.1096/fj.202000494RR. Epub 2020 Sep 18. FASEB J. 2020. PMID: 32946656
DNA methyltransferase 1 (DNMT1), which catalyzes DNA methylation and subsequently leads to the transcriptional repression of PTEN, is selectively induced in myofibroblasts from diseased livers. Sennoside A (SA), a major purgative constituent of senna and the Chinese herb r …
DNA methyltransferase 1 (DNMT1), which catalyzes DNA methylation and subsequently leads to the transcriptional repression of PTEN, is select …
Sennoside B inhibits PDGF receptor signaling and cell proliferation induced by PDGF-BB in human osteosarcoma cells.
Chen YC, Chang CN, Hsu HC, Chiou SJ, Lee LT, Hseu TH. Chen YC, et al. Life Sci. 2009 Jun 19;84(25-26):915-22. doi: 10.1016/j.lfs.2009.04.003. Epub 2009 Apr 22. Life Sci. 2009. PMID: 19393247
The effect was specific for sennoside B; other similar compounds including aloe-emodin, rhein and the meso isomer (sennoside A) failed to inhibit PDGFR activation or downstream signaling. Sennoside B also inhibited PDGF-BB stimulation of MG63 cell proliferati …
The effect was specific for sennoside B; other similar compounds including aloe-emodin, rhein and the meso isomer (sennoside A …
The influence of rhein 8-O-beta-D-glucopyranoside on the purgative action of sennoside A from rhubarb in mice.
Takayama K, Tsutsumi H, Ishizu T, Okamura N. Takayama K, et al. Biol Pharm Bull. 2012;35(12):2204-8. doi: 10.1248/bpb.b12-00632. Biol Pharm Bull. 2012. PMID: 23207772 Free article.
Sennoside A in rhubarb showed significantly accelerated metabolic activity in intestinal bacteria in comparison with sennoside A alone. ...Moreover, rhein, emodin and aloe-emodin also accelerated sennoside A metabolism. The purgative activity of sennoside
Sennoside A in rhubarb showed significantly accelerated metabolic activity in intestinal bacteria in comparison with sennoside
514 results