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Sensitization effect of thimerosal is mediated in vitro via reactive oxygen species and calcium signaling.
Migdal C, Foggia L, Tailhardat M, Courtellemont P, Haftek M, Serres M. Migdal C, et al. Toxicology. 2010 Jul-Aug;274(1-3):1-9. doi: 10.1016/j.tox.2010.04.016. Epub 2010 May 10. Toxicology. 2010. PMID: 20457211
Non-sensitizers, dichloronitrobenzene (DCNB), TSA and sodium dodecyl sulfate (SDS), an irritant, had no effect. U937 activation was prevented by cell pretreatment with N-acetyl-L-cysteine (NAC) but not with thiol-independent antioxidants except vitamin E which affec …
Non-sensitizers, dichloronitrobenzene (DCNB), TSA and sodium dodecyl sulfate (SDS), an irritant, had no effect. U937 activatio …
Hydrogen peroxide potentiates the EDHF phenomenon by promoting endothelial Ca2+ mobilization.
Edwards DH, Li Y, Griffith TM. Edwards DH, et al. Arterioscler Thromb Vasc Biol. 2008 Oct;28(10):1774-81. doi: 10.1161/ATVBAHA.108.172692. Epub 2008 Jul 31. Arterioscler Thromb Vasc Biol. 2008. PMID: 18669883
Imaging of cytosolic and endoplasmic reticulum [Ca(2+)] in rabbit aortic valve endothelial cells with Fura-2 and Mag-fluo-4 demonstrated that H(2)O(2) and thimerosal, which sensitizes the InsP(3) receptor, both enhanced CPA-evoked Ca(2+) release from stores, and tha …
Imaging of cytosolic and endoplasmic reticulum [Ca(2+)] in rabbit aortic valve endothelial cells with Fura-2 and Mag-fluo-4 demonstrated tha …