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The biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificity.
Sents W, Ivanova E, Lambrecht C, Haesen D, Janssens V. Sents W, et al. FEBS J. 2013 Jan;280(2):644-61. doi: 10.1111/j.1742-4658.2012.08579.x. Epub 2012 Apr 25. FEBS J. 2013. PMID: 22443683 Free article. Review.
Loss of protein phosphatase 2A regulatory subunit B56δ promotes spontaneous tumorigenesis in vivo.
Lambrecht C, Libbrecht L, Sagaert X, Pauwels P, Hoorne Y, Crowther J, Louis JV, Sents W, Sablina A, Janssens V. Lambrecht C, et al. Among authors: sents w. Oncogene. 2018 Jan 25;37(4):544-552. doi: 10.1038/onc.2017.350. Epub 2017 Oct 2. Oncogene. 2018. PMID: 28967903
PP2A Inactivation Mediated by PPP2R4 Haploinsufficiency Promotes Cancer Development.
Sents W, Meeusen B, Kalev P, Radaelli E, Sagaert X, Miermans E, Haesen D, Lambrecht C, Dewerchin M, Carmeliet P, Westermarck J, Sablina A, Janssens V. Sents W, et al. Cancer Res. 2017 Dec 15;77(24):6825-6837. doi: 10.1158/0008-5472.CAN-16-2911. Epub 2017 Oct 18. Cancer Res. 2017. PMID: 29046336 Free article.
The Basic Biology of PP2A in Hematologic Cells and Malignancies.
Haesen D, Sents W, Lemaire K, Hoorne Y, Janssens V. Haesen D, et al. Among authors: sents w. Front Oncol. 2014 Dec 11;4:347. doi: 10.3389/fonc.2014.00347. eCollection 2014. Front Oncol. 2014. PMID: 25566494 Free PMC article. Review.
Structure, regulation, and pharmacological modulation of PP2A phosphatases.
Lambrecht C, Haesen D, Sents W, Ivanova E, Janssens V. Lambrecht C, et al. Among authors: sents w. Methods Mol Biol. 2013;1053:283-305. doi: 10.1007/978-1-62703-562-0_17. Methods Mol Biol. 2013. PMID: 23860660 Review.
Mice lacking phosphatase PP2A subunit PR61/B'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3beta.
Louis JV, Martens E, Borghgraef P, Lambrecht C, Sents W, Longin S, Zwaenepoel K, Pijnenborg R, Landrieu I, Lippens G, Ledermann B, Götz J, Van Leuven F, Goris J, Janssens V. Louis JV, et al. Among authors: sents w. Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6957-62. doi: 10.1073/pnas.1018777108. Epub 2011 Apr 11. Proc Natl Acad Sci U S A. 2011. PMID: 21482799 Free PMC article.
Stalk cell phenotype depends on integration of Notch and Smad1/5 signaling cascades.
Moya IM, Umans L, Maas E, Pereira PN, Beets K, Francis A, Sents W, Robertson EJ, Mummery CL, Huylebroeck D, Zwijsen A. Moya IM, et al. Among authors: sents w. Dev Cell. 2012 Mar 13;22(3):501-14. doi: 10.1016/j.devcel.2012.01.007. Epub 2012 Feb 23. Dev Cell. 2012. PMID: 22364862 Free PMC article.
Doxorubicin plus dacarbazine, doxorubicin plus ifosfamide, or doxorubicin alone as a first-line treatment for advanced leiomyosarcoma: A propensity score matching analysis from the European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group.
D'Ambrosio L, Touati N, Blay JY, Grignani G, Flippot R, Czarnecka AM, Piperno-Neumann S, Martin-Broto J, Sanfilippo R, Katz D, Duffaud F, Vincenzi B, Stark DP, Mazzeo F, Tuchscherer A, Chevreau C, Sherriff J, Estival A, Litière S, Sents W, Ray-Coquard I, Tolomeo F, Le Cesne A, Rutkowski P, Stacchiotti S, Kasper B, Gelderblom H, Gronchi A; European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group. D'Ambrosio L, et al. Among authors: sents w. Cancer. 2020 Jun 1;126(11):2637-2647. doi: 10.1002/cncr.32795. Epub 2020 Mar 4. Cancer. 2020. PMID: 32129883
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