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Structural insights into recognition of c-di-AMP by the ydaO riboswitch.
Gao A, Serganov A. Gao A, et al. Among authors: serganov a. Nat Chem Biol. 2014 Sep;10(9):787-92. doi: 10.1038/nchembio.1607. Epub 2014 Aug 3. Nat Chem Biol. 2014. PMID: 25086507 Free PMC article.
Bacterial second messenger cyclic di-AMP (c-di-AMP) is implicated in signaling DNA damage and cell wall stress through interactions with several protein receptors and a widespread ydaO-type riboswitch. ...In both species, the RNA adopts an unforeseen 'square'-shaped pseudo …
Bacterial second messenger cyclic di-AMP (c-di-AMP) is implicated in signaling DNA damage and cell wall stress through interactions with sev …
ykkC riboswitches employ an add-on helix to adjust specificity for polyanionic ligands.
Peselis A, Serganov A. Peselis A, et al. Among authors: serganov a. Nat Chem Biol. 2018 Sep;14(9):887-894. doi: 10.1038/s41589-018-0114-4. Epub 2018 Aug 17. Nat Chem Biol. 2018. PMID: 30120360 Free PMC article.
Crystal structure reveals specific recognition of a G-quadruplex RNA by a β-turn in the RGG motif of FMRP.
Vasilyev N, Polonskaia A, Darnell JC, Darnell RB, Patel DJ, Serganov A. Vasilyev N, et al. Among authors: serganov a. Proc Natl Acad Sci U S A. 2015 Sep 29;112(39):E5391-400. doi: 10.1073/pnas.1515737112. Epub 2015 Sep 15. Proc Natl Acad Sci U S A. 2015. PMID: 26374839 Free PMC article.
Fragile X Mental Retardation Protein (FMRP) is a regulatory RNA binding protein that plays a central role in the development of several human disorders including Fragile X Syndrome (FXS) and autism. ...Many of these interactions critically depend on a type I …
Fragile X Mental Retardation Protein (FMRP) is a regulatory RNA binding protein that plays a central role in the development o …
Preparation and Crystallization of Riboswitches.
Peselis A, Gao A, Serganov A. Peselis A, et al. Among authors: serganov a. Methods Mol Biol. 2016;1320:21-36. doi: 10.1007/978-1-4939-2763-0_3. Methods Mol Biol. 2016. PMID: 26227035
Discovered over a decade ago in all three kingdoms of life, riboswitches specifically and directly interact with various metabolites and regulate expression of multiple genes, often associated with metabolism and transport of small molecules. Thus, riboswitches do not depe …
Discovered over a decade ago in all three kingdoms of life, riboswitches specifically and directly interact with various metabolites …
Preparation of Short 5'-Triphosphorylated Oligoribonucleotides for Crystallographic and Biochemical Studies.
Vasilyev N, Serganov A. Vasilyev N, et al. Among authors: serganov a. Methods Mol Biol. 2016;1320:11-20. doi: 10.1007/978-1-4939-2763-0_2. Methods Mol Biol. 2016. PMID: 26227034
The chapter describes the principles of construct design, in vitro transcription and RNA purification applied for characterization of a protein that targets the 5' end of RNA....
The chapter describes the principles of construct design, in vitro transcription and RNA purification applied for characterization of a
Cooperativity, allostery and synergism in ligand binding to riboswitches.
Peselis A, Gao A, Serganov A. Peselis A, et al. Among authors: serganov a. Biochimie. 2015 Oct;117:100-9. doi: 10.1016/j.biochi.2015.06.028. Epub 2015 Jul 2. Biochimie. 2015. PMID: 26143008 Free PMC article. Review.
Recent progress in identification and characterization of novel types of non-coding RNAs has proven that RNAs carry out a variety of cellular functions ranging from scaffolding to gene expression control. ...Here we present an overview of the biochemical, genetic, and stru …
Recent progress in identification and characterization of novel types of non-coding RNAs has proven that RNAs carry out a variety of …
Structures of RNA complexes with the Escherichia coli RNA pyrophosphohydrolase RppH unveil the basis for specific 5'-end-dependent mRNA decay.
Vasilyev N, Serganov A. Vasilyev N, et al. Among authors: serganov a. J Biol Chem. 2015 Apr 10;290(15):9487-99. doi: 10.1074/jbc.M114.634824. Epub 2015 Feb 5. J Biol Chem. 2015. PMID: 25657011 Free PMC article.
The RNA pyrophosphohydrolase RppH, a member of the Nudix hydrolase superfamily, triggers this degradation pathway by removing pyrophosphate from the triphosphorylated RNA 5' terminus. ...These structures show distinct conformations of EcRppH·RNA complexes on the catalytic …
The RNA pyrophosphohydrolase RppH, a member of the Nudix hydrolase superfamily, triggers this degradation pathway by removing pyropho …
Structure and function of pseudoknots involved in gene expression control.
Peselis A, Serganov A. Peselis A, et al. Among authors: serganov a. Wiley Interdiscip Rev RNA. 2014 Nov-Dec;5(6):803-22. doi: 10.1002/wrna.1247. Epub 2014 Jul 8. Wiley Interdiscip Rev RNA. 2014. PMID: 25044223 Free PMC article. Review.
Natural RNA molecules can have a high degree of structural complexity but even the most complexly folded RNAs are assembled from simple structural building blocks. ...One common folding motif of RNA is a pseudoknot, defined as a bipartite helical structure fo …
Natural RNA molecules can have a high degree of structural complexity but even the most complexly folded RNAs are assembled from simp …
A decade of riboswitches.
Serganov A, Nudler E. Serganov A, et al. Cell. 2013 Jan 17;152(1-2):17-24. doi: 10.1016/j.cell.2012.12.024. Cell. 2013. PMID: 23332744 Free PMC article. Review.
During the last decade, naturally occurring RNA sensor elements have been found to bind a range of small metabolites and ions and to exert regulatory control of transcription, translation, splicing, and RNA stability. ...
During the last decade, naturally occurring RNA sensor elements have been found to bind a range of small metabolites and ions and to …
Themes and variations in riboswitch structure and function.
Peselis A, Serganov A. Peselis A, et al. Among authors: serganov a. Biochim Biophys Acta. 2014 Oct;1839(10):908-918. doi: 10.1016/j.bbagrm.2014.02.012. Epub 2014 Feb 28. Biochim Biophys Acta. 2014. PMID: 24583553 Free PMC article. Review.
Discovered a decade ago, riboswitches represent a diverse group of non-coding mRNA regions that possess a unique ability to directly sense cellular metabolites and modulate gene expression through formation of alternative metabolite-free and metabolite-bound …
Discovered a decade ago, riboswitches represent a diverse group of non-coding mRNA regions that possess a unique abilit …
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