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Cloning, characterization, and chromosomal localization to 4p16 of the human gene (LRPAP1) coding for the alpha 2-macroglobulin receptor-associated protein and structural comparison with the murine gene coding for the 44-kDa heparin-binding protein.
Van Leuven F, Hilliker C, Serneels L, Umans L, Overbergh L, De Strooper B, Fryns JP, Van den Berghe H. Van Leuven F, et al. Among authors: serneels l. Genomics. 1995 Jan 20;25(2):492-500. doi: 10.1016/0888-7543(95)80050-v. Genomics. 1995. PMID: 7789983
Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency.
Herreman A, Hartmann D, Annaert W, Saftig P, Craessaerts K, Serneels L, Umans L, Schrijvers V, Checler F, Vanderstichele H, Baekelandt V, Dressel R, Cupers P, Huylebroeck D, Zwijsen A, Van Leuven F, De Strooper B. Herreman A, et al. Among authors: serneels l. Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):11872-7. doi: 10.1073/pnas.96.21.11872. Proc Natl Acad Sci U S A. 1999. PMID: 10518543 Free PMC article.
No endogenous A beta production in presenilin-deficient fibroblasts.
Nyabi O, Pype S, Mercken M, Herreman A, Saftig P, Craessaerts K, Serneels L, Annaert W, De Strooper B. Nyabi O, et al. Among authors: serneels l. Nat Cell Biol. 2002 Jul;4(7):E164; author reply E165-6. doi: 10.1038/ncb0702-e164a. Nat Cell Biol. 2002. PMID: 12105423 No abstract available.
64 results