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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 5
1947 7
1948 13
1949 14
1950 26
1951 33
1952 66
1953 74
1954 81
1955 154
1956 244
1957 341
1958 333
1959 335
1960 377
1961 412
1962 493
1963 720
1964 946
1965 663
1966 780
1967 952
1968 1153
1969 1062
1970 1189
1971 1301
1972 1407
1973 1446
1974 1635
1975 1505
1976 1407
1977 1367
1978 1386
1979 1374
1980 1375
1981 1452
1982 1586
1983 1510
1984 1672
1985 1933
1986 1957
1987 1774
1988 1835
1989 1939
1990 2118
1991 2118
1992 2239
1993 2165
1994 2101
1995 2095
1996 2129
1997 2123
1998 2141
1999 2031
2000 2067
2001 2081
2002 1991
2003 1963
2004 2046
2005 2092
2006 2140
2007 2308
2008 2306
2009 2108
2010 2161
2011 2087
2012 2119
2013 2108
2014 1980
2015 1900
2016 1856
2017 1674
2018 1667
2019 1641
2020 1587
2021 1605
2022 1739
2023 1654
2024 1333
2025 79

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104,275 results

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Page 1
Vilazodone: a 5-HT1A receptor agonist/serotonin transporter inhibitor for the treatment of affective disorders.
Dawson LA, Watson JM. Dawson LA, et al. CNS Neurosci Ther. 2009 Summer;15(2):107-17. doi: 10.1111/j.1755-5949.2008.00067.x. CNS Neurosci Ther. 2009. PMID: 19499624 Free PMC article. Review.
Vilazodone (EMD 68843; 5-{4-[4-(5-cyano-3-indolyl)-butyl]-1-piperazinyl}-benzofuran-2-carboxamide hydrochloride) is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatme …
Vilazodone (EMD 68843; 5-{4-[4-(5-cyano-3-indolyl)-butyl]-1-piperazinyl}-benzofuran-2-carboxamide hydrochloride) is a combined serotonin …
Eletriptan.
Gawel MJ, Grujich NN. Gawel MJ, et al. Expert Opin Investig Drugs. 2001 Oct;10(10):1869-74. doi: 10.1517/13543784.10.10.1869. Expert Opin Investig Drugs. 2001. PMID: 11772292 Review.
Eletriptan (Relpax, Pfizer) is one of a group of anti-migraine medications commonly referred to as 'triptans'. It is a potent serotonin agonist at the 5-HT(1B/1D) receptor and is indicated for the acute treatment of migraine headaches. ...
Eletriptan (Relpax, Pfizer) is one of a group of anti-migraine medications commonly referred to as 'triptans'. It is a potent serotonin …
Lasmiditan: First Approval.
Lamb YN. Lamb YN. Drugs. 2019 Dec;79(18):1989-1996. doi: 10.1007/s40265-019-01225-7. Drugs. 2019. PMID: 31749059 Review.
Lasmiditan (REYVOW; Eli Lilly and Company) is an orally available serotonin (5-HT)(1F) receptor agonist. In October 2019, the US FDA approved lasmiditan 50 mg and 100 mg tablets for the acute treatment of migraine with or without aura in adults. ...
Lasmiditan (REYVOW; Eli Lilly and Company) is an orally available serotonin (5-HT)(1F) receptor agonist. In October 201 …
Frovatriptan.
Easthope SE, Goa KL. Easthope SE, et al. CNS Drugs. 2001;15(12):969-76; discussion 977-8. doi: 10.2165/00023210-200115120-00006. CNS Drugs. 2001. PMID: 11735616 Review.
black triangle Frovatriptan, a new serotonin receptor agonist developed for the acute treatment of migraine, has high affinity for serotonin 5-HT1B and 5-HT1D receptor subtypes and is a potent stimulator of contraction in human basilar arteries. …
black triangle Frovatriptan, a new serotonin receptor agonist developed for the acute treatment of migraine, has high a …
Tegaserod.
Scott LJ, Perry CM. Scott LJ, et al. Drugs. 1999 Sep;58(3):491-6; discussion 497-8. doi: 10.2165/00003495-199958030-00013. Drugs. 1999. PMID: 10493276 Review.
Tegaserod is a serotonin (5-hydroxytryptamine; 5-HT) receptor partial agonist which has been investigated for the treatment of irritable bowel syndrome (IBS). ...
Tegaserod is a serotonin (5-hydroxytryptamine; 5-HT) receptor partial agonist which has been investigated for the treat …
Frovatriptan: a selective type 1B/1D serotonin receptor agonist for the treatment of migraine headache.
Cole P, Rabasseda X. Cole P, et al. Drugs Today (Barc). 2002 Sep;38(9):615-29. doi: 10.1358/dot.2002.38.9.696537. Drugs Today (Barc). 2002. PMID: 12582449 Review.
It has been shown in pharmacological tests to act selectively as a potent agonist of serotonin 5-HT1B/1D receptors. Frovatriptan has been well tolerated in humans and efficacious in reducing headache pain and duration in clinical trials, which have also indicated th …
It has been shown in pharmacological tests to act selectively as a potent agonist of serotonin 5-HT1B/1D receptors. Frovatript …
Naratriptan.
Massiou H. Massiou H. Curr Med Res Opin. 2001;17 Suppl 1:s51-3. doi: 10.1185/0300799039117016. Curr Med Res Opin. 2001. PMID: 12463278 Review.
Naratriptan is a selective 5-HT(1B/1D) receptor agonist, with a high affinity at the 5-HT(1B), 5-HT(1D) and 5-HT(1F) receptor subtypes. ...
Naratriptan is a selective 5-HT(1B/1D) receptor agonist, with a high affinity at the 5-HT(1B), 5-HT(1D) and 5-HT(1F) recept …
Serotonin agonist-induced decreases in intermale aggression are dependent on brain region and receptor subtype.
Cologer-Clifford A, Simon NG, Lu SF, Smoluk SA. Cologer-Clifford A, et al. Pharmacol Biochem Behav. 1997 Oct;58(2):425-30. doi: 10.1016/s0091-3057(97)00295-5. Pharmacol Biochem Behav. 1997. PMID: 9300602
Testosterone (T) and its androgenic and estrogenic metabolites modulate the ability of serotonin (5-HT)1A and 5-HT1B agonists to inhibit intermale aggressive behavior. This study tested whether the lateral septum (LS) and medial preoptic area (MPO), which are part o …
Testosterone (T) and its androgenic and estrogenic metabolites modulate the ability of serotonin (5-HT)1A and 5-HT1B agonists …
Photoactivatable Agonist-Antagonist Pair as a Tool for Precise Spatiotemporal Control of Serotonin Receptor 2C Signaling.
Kim ST, Doukmak EJ, Shanguhyia M, Gray DJ, Steinhardt RC. Kim ST, et al. ACS Chem Neurosci. 2023 Oct 4;14(19):3665-3673. doi: 10.1021/acschemneuro.3c00290. Epub 2023 Sep 18. ACS Chem Neurosci. 2023. PMID: 37721710 Free PMC article.
These conjugates release the bioactive drug upon illumination with green light (agonist) or red light (antagonist). We report on the synthesis, characterization, and bioactivity testing of the conjugates against the 5-HT(2C) receptor. ...In live cells expressing the …
These conjugates release the bioactive drug upon illumination with green light (agonist) or red light (antagonist). We report on the …
Eletriptan in migraine.
Diener HC. Diener HC. Expert Rev Neurother. 2005 Jan;5(1):43-53. doi: 10.1586/14737175.5.1.43. Expert Rev Neurother. 2005. PMID: 15853473 Review.
Eletriptan, similar to other triptans, is a potent 5-HT(1B/1D) receptor agonist with a high selectivity for cranial versus coronary artery constriction and favorable pharmacokinetic profile. ...
Eletriptan, similar to other triptans, is a potent 5-HT(1B/1D) receptor agonist with a high selectivity for cranial versus cor …
104,275 results
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