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Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases.
Lynch CJ, Bernad R, Martínez-Val A, Shahbazi MN, Nóbrega-Pereira S, Calvo I, Blanco-Aparicio C, Tarantino C, Garreta E, Richart-Ginés L, Alcazar N, Graña-Castro O, Gómez-Lopez G, Aksoy I, Muñoz-Martín M, Martinez S, Ortega S, Prieto S, Simboeck E, Camasses A, Stephan-Otto Attolini C, Fernandez AF, Sierra MI, Fraga MF, Pastor J, Fisher D, Montserrat N, Savatier P, Muñoz J, Zernicka-Goetz M, Serrano M. Lynch CJ, et al. Among authors: serrano m. Nat Cell Biol. 2020 Oct;22(10):1223-1238. doi: 10.1038/s41556-020-0573-1. Epub 2020 Sep 28. Nat Cell Biol. 2020. PMID: 32989249 Free article.
Lysosomal trapping of palbociclib and its functional implications.
Llanos S, Megias D, Blanco-Aparicio C, Hernández-Encinas E, Rovira M, Pietrocola F, Serrano M. Llanos S, et al. Among authors: serrano m. Oncogene. 2019 May;38(20):3886-3902. doi: 10.1038/s41388-019-0695-8. Epub 2019 Jan 28. Oncogene. 2019. PMID: 30692638 Free PMC article.
Transient exposure to miR-203 enhances the differentiation capacity of established pluripotent stem cells.
Salazar-Roa M, Trakala M, Álvarez-Fernández M, Valdés-Mora F, Zhong C, Muñoz J, Yu Y, Peters TJ, Graña-Castro O, Serrano R, Zapatero-Solana E, Abad M, Bueno MJ, Gómez de Cedrón M, Fernández-Piqueras J, Serrano M, Blasco MA, Wang DZ, Clark SJ, Izpisua-Belmonte JC, Ortega S, Malumbres M. Salazar-Roa M, et al. Among authors: serrano m, serrano r. EMBO J. 2020 Aug 17;39(16):e104324. doi: 10.15252/embj.2019104324. Epub 2020 Jul 2. EMBO J. 2020. PMID: 32614092 Free PMC article.
Induction of Lysosome Membrane Permeabilization as a Therapeutic Strategy to Target Pancreatic Cancer Stem Cells.
Cash TP, Alcalá S, Rico-Ferreira MDR, Hernández-Encinas E, García J, Albarrán MI, Valle S, Muñoz J, Martínez-González S, Blanco-Aparicio C, Pastor J, Serrano M, Sainz B Jr. Cash TP, et al. Among authors: serrano m. Cancers (Basel). 2020 Jul 4;12(7):1790. doi: 10.3390/cancers12071790. Cancers (Basel). 2020. PMID: 32635473 Free PMC article.
Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming.
Chondronasiou D, Gill D, Mosteiro L, Urdinguio RG, Berenguer-Llergo A, Aguilera M, Durand S, Aprahamian F, Nirmalathasan N, Abad M, Martin-Herranz DE, Stephan-Otto Attolini C, Prats N, Kroemer G, Fraga MF, Reik W, Serrano M. Chondronasiou D, et al. Among authors: serrano m. Aging Cell. 2022 Mar;21(3):e13578. doi: 10.1111/acel.13578. Epub 2022 Mar 2. Aging Cell. 2022. PMID: 35235716 Free PMC article.
Natural killer cells act as an extrinsic barrier for in vivo reprogramming.
Melendez E, Chondronasiou D, Mosteiro L, Martínez de Villarreal J, Fernández-Alfara M, Lynch CJ, Grimm D, Real FX, Alcamí J, Climent N, Pietrocola F, Serrano M. Melendez E, et al. Among authors: serrano m. Development. 2022 Apr 15;149(8):dev200361. doi: 10.1242/dev.200361. Epub 2022 Apr 22. Development. 2022. PMID: 35420133 Free PMC article.
The lysosomal proteome of senescent cells contributes to the senescence secretome.
Rovira M, Sereda R, Pladevall-Morera D, Ramponi V, Marin I, Maus M, Madrigal-Matute J, Díaz A, García F, Muñoz J, Cuervo AM, Serrano M. Rovira M, et al. Among authors: serrano m. Aging Cell. 2022 Oct;21(10):e13707. doi: 10.1111/acel.13707. Epub 2022 Sep 10. Aging Cell. 2022. PMID: 36087066 Free PMC article.
1,938 results