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Serum pharmacodynamic biomarkers for chronic corticosteroid treatment of children.
Hathout Y, Conklin LS, Seol H, Gordish-Dressman H, Brown KJ, Morgenroth LP, Nagaraju K, Heier CR, Damsker JM, van den Anker JN, Henricson E, Clemens PR, Mah JK, McDonald C, Hoffman EP. Hathout Y, et al. Sci Rep. 2016 Aug 17;6:31727. doi: 10.1038/srep31727. Sci Rep. 2016. PMID: 27530235 Free PMC article.
To identify potential corticosteroid responsive biomarkers we performed proteome profiling of serum samples from DMD and IBD patients with and without corticosteroid treatment using SOMAscan aptamer panel testing 1,129 proteins in <0.1 cc of …
To identify potential corticosteroid responsive biomarkers we performed proteome profiling of serum samples from DMD an …
Omalizumab for asthma in adults and children.
Normansell R, Walker S, Milan SJ, Walters EH, Nair P. Normansell R, et al. Cochrane Database Syst Rev. 2014 Jan 13;(1):CD003559. doi: 10.1002/14651858.CD003559.pub4. Cochrane Database Syst Rev. 2014. PMID: 24414989 Review.
A recent update of National Institute for Health and Care Excellence (NICE) guidance in 2013 recommends omalizumab for use as add-on therapy in adults and children over six years of age with inadequately controlled severe persistent allergic IgE-mediated asthma who …
A recent update of National Institute for Health and Care Excellence (NICE) guidance in 2013 recommends omalizumab for use as add-on ther
Serum biomarkers of glucocorticoid response and safety in anti-neutrophil cytoplasmic antibody-associated vasculitis and juvenile dermatomyositis.
Conklin LS, Merkel PA, Pachman LM, Parikh H, Tawalbeh S, Damsker JM, Cuthbertson DD, Morgan GA, Monach PA, Hathout Y, Nagaraju K, van den Anker J, McAlear CA, Hoffman EP. Conklin LS, et al. Steroids. 2018 Dec;140:159-166. doi: 10.1016/j.steroids.2018.10.008. Epub 2018 Oct 21. Steroids. 2018. PMID: 30352204 Free PMC article.
We sought to define pharmacodynamic biomarkers of therapeutic efficacy and safety concerns of glucocorticoid treatment for these two disorders. ...Serial serum samples from patients with AAV (n = 30) and JDM (n = 12) were obtained during active disease …
We sought to define pharmacodynamic biomarkers of therapeutic efficacy and safety concerns of glucocorticoid treatment
Serum Eosinophil Cationic Protein Is a Useful Marker for Assessing the Efficacy of Inhaled Corticosteroid Therapy in Children with Bronchial Asthma.
Guo CL, Sun XM, Wang XW, Guo Q. Guo CL, et al. Tohoku J Exp Med. 2017 Aug;242(4):263-271. doi: 10.1620/tjem.242.263. Tohoku J Exp Med. 2017. PMID: 28781336 Free article. Clinical Trial.
Bronchial asthma (BA) is a chronic inflammatory disorder of airways for which the effective therapies include inhaled corticosteroids (ICS) and short-acting β2-adrenoreceptor agonist (SABA). ...ROC results revealed the diagnostic efficiency of serum ECP level …
Bronchial asthma (BA) is a chronic inflammatory disorder of airways for which the effective therapies include inhaled corticostero
Controlling the Risk Domain in Pediatric Asthma through Personalized Care.
Anderson WC 3rd, Szefler SJ. Anderson WC 3rd, et al. Semin Respir Crit Care Med. 2018 Feb;39(1):36-44. doi: 10.1055/s-0037-1608707. Epub 2018 Feb 10. Semin Respir Crit Care Med. 2018. PMID: 29427984 Review.
Strategies to control the risk domain of NHLBI EPR-3 (National Heart, Lung, and Blood Institute Expert Panel Report-3) asthma guidelines, which includes exacerbations requiring systemic corticosteroids, reduction in lung growth, and progressive loss of lung function, and …
Strategies to control the risk domain of NHLBI EPR-3 (National Heart, Lung, and Blood Institute Expert Panel Report-3) asthma guidelines, wh …
Bone mass and biochemical markers of bone turnover in children and adolescents with chronic immune thrombocytopenia: relation to corticosteroid therapy and vitamin D receptor gene polymorphisms.
Tantawy AA, El Bostany EA, Matter RM, El Ghoroury EA, Ragab S, El Sherif NH. Tantawy AA, et al. Platelets. 2013;24(4):282-7. doi: 10.3109/09537104.2012.690544. Epub 2012 Jun 6. Platelets. 2013. PMID: 22671537
FokI gene polymorphism may be one of the contributing factors in bone loss in patients on chronic steroid therapy. High cumulative doses of corticosteroids increased bone resorption in young chronic ITP patients. ...Protocols of therapy of ch
FokI gene polymorphism may be one of the contributing factors in bone loss in patients on chronic steroid therapy. High cumula …
Changes in markers of bone metabolism during dexamethasone treatment for chronic lung disease in preterm infants.
Ng PC, Lam CW, Wong GW, Lee CH, Cheng PS, Fok TF, Chan IH, Wong E, Cheung K, Lee SY. Ng PC, et al. Arch Dis Child Fetal Neonatal Ed. 2002 Jan;86(1):F49-54. doi: 10.1136/fn.86.1.f49. Arch Dis Child Fetal Neonatal Ed. 2002. PMID: 11815549 Free PMC article.
However, it was significantly lower than the urinary Dpd concentration at T(wk-6) of the non-treatment group. The rate of increase in lower leg length was significantly higher in the non-treatment group between weeks 3 and 6 than in the corresponding period during d …
However, it was significantly lower than the urinary Dpd concentration at T(wk-6) of the non-treatment group. The rate of increase in …
High dickkopf-1 levels in sera and leukocytes from children with 21-hydroxylase deficiency on chronic glucocorticoid treatment.
Brunetti G, Faienza MF, Piacente L, Ventura A, Oranger A, Carbone C, Benedetto AD, Colaianni G, Gigante M, Mori G, Gesualdo L, Colucci S, Cavallo L, Grano M. Brunetti G, et al. Am J Physiol Endocrinol Metab. 2013 Mar 1;304(5):E546-54. doi: 10.1152/ajpendo.00535.2012. Epub 2013 Jan 8. Am J Physiol Endocrinol Metab. 2013. PMID: 23299503 Free article.
Children with 21-hydroxylase deficiency (21-OHD) need chronic glucocorticoid (cGC) therapy to replace congenital deficit of cortisol synthesis, and this therapy is the most frequent and severe form of drug-induced osteoporosis. ...We also found a corre
Children with 21-hydroxylase deficiency (21-OHD) need chronic glucocorticoid (cGC) therapy to replace congenital defici
Cortisol level as risk factor for malignant hematologic pathology in children exposed to ionizing radiation after Chornobyl accident.
Bebeshko VG, Bruslova KM, Pushkareva TI, Tsvietkova NM, Lyashenko LO, Sergeeva AS, Kuzmenko VF, Iatsemyrskiy SM, Samson YM, Boyarsky VG, Tryhlіb IV. Bebeshko VG, et al. Probl Radiac Med Radiobiol. 2017 Dec;22:306-315. Probl Radiac Med Radiobiol. 2017. PMID: 29286515 English, Ukrainian.
It is shown, that lower initial blood serum cortisol level in ALL children correlates to a greater probability of relapse (Rs = -0,67). ...However, these doses did not affect blood serum cortisol levels in children and the course of AL. CONCLUSIONS: Th …
It is shown, that lower initial blood serum cortisol level in ALL children correlates to a greater probability of relapse (Rs …
Balneotherapeutic effects of high mineral spring water on the atopic dermatitis-like inflammation in hairless mice via immunomodulation and redox balance.
Bajgai J, Fadriquela A, Ara J, Begum R, Ahmed MF, Kim CS, Kim SK, Shim KY, Lee KJ. Bajgai J, et al. BMC Complement Altern Med. 2017 Oct 13;17(1):481. doi: 10.1186/s12906-017-1985-8. BMC Complement Altern Med. 2017. PMID: 29029618 Free PMC article.
BACKGROUND: Atopic dermatitis (AD) is a chronic relapsing allergic inflammatory skin disease that currently affects millions of children and adults worldwide. ...In parallel, total reactive oxygen species (ROS) of serum level was significantly decreased in PH …
BACKGROUND: Atopic dermatitis (AD) is a chronic relapsing allergic inflammatory skin disease that currently affects millions of ch
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