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Potential pharmacological control of the NF-κB pathway.
Sethi G, Tergaonkar V. Sethi G, et al. Trends Pharmacol Sci. 2009 Jun;30(6):313-21. doi: 10.1016/j.tips.2009.03.004. Epub 2009 May 14. Trends Pharmacol Sci. 2009. PMID: 19446347 Review.
Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells.
Li F, Fernandez PP, Rajendran P, Hui KM, Sethi G. Li F, et al. Among authors: sethi g. Cancer Lett. 2010 Jun 28;292(2):197-207. doi: 10.1016/j.canlet.2009.12.003. Epub 2010 Jan 6. Cancer Lett. 2010. PMID: 20053498
Identification of beta-escin as a novel inhibitor of signal transducer and activator of transcription 3/Janus-activated kinase 2 signaling pathway that suppresses proliferation and induces apoptosis in human hepatocellular carcinoma cells.
Tan SM, Li F, Rajendran P, Kumar AP, Hui KM, Sethi G. Tan SM, et al. Among authors: sethi g. J Pharmacol Exp Ther. 2010 Jul;334(1):285-93. doi: 10.1124/jpet.110.165498. Epub 2010 Apr 8. J Pharmacol Exp Ther. 2010. PMID: 20378717
Butein downregulates chemokine receptor CXCR4 expression and function through suppression of NF-κB activation in breast and pancreatic tumor cells.
Chua AW, Hay HS, Rajendran P, Shanmugam MK, Li F, Bist P, Koay ES, Lim LH, Kumar AP, Sethi G. Chua AW, et al. Among authors: sethi g. Biochem Pharmacol. 2010 Nov 15;80(10):1553-62. doi: 10.1016/j.bcp.2010.07.045. Epub 2010 Aug 10. Biochem Pharmacol. 2010. PMID: 20699088
Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway.
Li F, Rajendran P, Sethi G. Li F, et al. Among authors: sethi g. Br J Pharmacol. 2010 Oct;161(3):541-54. doi: 10.1111/j.1476-5381.2010.00874.x. Br J Pharmacol. 2010. PMID: 20880395 Free PMC article.
Suppression of signal transducer and activator of transcription 3 activation by butein inhibits growth of human hepatocellular carcinoma in vivo.
Rajendran P, Ong TH, Chen L, Li F, Shanmugam MK, Vali S, Abbasi T, Kapoor S, Sharma A, Kumar AP, Hui KM, Sethi G. Rajendran P, et al. Among authors: sethi g. Clin Cancer Res. 2011 Mar 15;17(6):1425-39. doi: 10.1158/1078-0432.CCR-10-1123. Epub 2010 Dec 3. Clin Cancer Res. 2011. PMID: 21131551
Molecular targets of celastrol derived from Thunder of God Vine: potential role in the treatment of inflammatory disorders and cancer.
Kannaiyan R, Shanmugam MK, Sethi G. Kannaiyan R, et al. Among authors: sethi g. Cancer Lett. 2011 Apr 1;303(1):9-20. doi: 10.1016/j.canlet.2010.10.025. Epub 2010 Dec 17. Cancer Lett. 2011. PMID: 21168266 Review.
γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent.
Rajendran P, Li F, Manu KA, Shanmugam MK, Loo SY, Kumar AP, Sethi G. Rajendran P, et al. Among authors: sethi g. Br J Pharmacol. 2011 May;163(2):283-98. doi: 10.1111/j.1476-5381.2010.01187.x. Br J Pharmacol. 2011. PMID: 21198544 Free PMC article.
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