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Autoreactive T cells can be protected from tolerance induction through competition by flanking determinants for access to class II MHC.
Maverakis E, Beech J, Stevens DB, Ametani A, Brossay L, van den Elzen P, Mendoza R, Thai Q, Macias LH, Ethell D, Campagnoni CW, Campagnoni AT, Sette A, Sercarz EE. Maverakis E, et al. Among authors: sette a. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5342-7. doi: 10.1073/pnas.0936151100. Epub 2003 Apr 21. Proc Natl Acad Sci U S A. 2003. PMID: 12707414 Free PMC article.
In silico prediction of peptides binding to multiple HLA-DR molecules accurately identifies immunodominant epitopes from gp43 of Paracoccidioides brasiliensis frequently recognized in primary peripheral blood mononuclear cell responses from sensitized individuals.
Iwai LK, Yoshida M, Sidney J, Shikanai-Yasuda MA, Goldberg AC, Juliano MA, Hammer J, Juliano L, Sette A, Kalil J, Travassos LR, Cunha-Neto E. Iwai LK, et al. Among authors: sette a. Mol Med. 2003 Sep-Dec;9(9-12):209-19. Mol Med. 2003. PMID: 15208742 Free PMC article.
975 results