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Novel Roles of Epoxyeicosanoids in Regulating Cardiac Mitochondria.

El-Sikhry HE, Alsaleh N, Dakarapu R, Falck JR, Seubert JM. El-Sikhry HE, et al. Among authors: seubert jm. PLoS One. 2016 Aug 5;11(8):e0160380. doi: 10.1371/journal.pone.0160380. eCollection 2016. PLoS One. 2016. PMID: 27494529 Free PMC article.

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Role of soluble epoxide hydrolase in postischemic recovery of heart contractile function.

Seubert JM, Sinal CJ, Graves J, DeGraff LM, Bradbury JA, Lee CR, Goralski K, Carey MA, Luria A, Newman JW, Hammock BD, Falck JR, Roberts H, Rockman HA, Murphy E, Zeldin DC. Seubert JM, et al. Circ Res. 2006 Aug 18;99(4):442-50. doi: 10.1161/01.RES.0000237390.92932.37. Epub 2006 Jul 20. Circ Res. 2006. PMID: 16857962 Free PMC article.

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Role of epoxyeicosatrienoic acids in protecting the myocardium following ischemia/reperfusion injury.

Seubert JM, Zeldin DC, Nithipatikom K, Gross GJ. Seubert JM, et al. Prostaglandins Other Lipid Mediat. 2007 Jan;82(1-4):50-9. doi: 10.1016/j.prostaglandins.2006.05.017. Epub 2006 Jul 10. Prostaglandins Other Lipid Mediat. 2007. PMID: 17164132 Free PMC article. Review.

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Epoxyeicosatrienoic acid prevents postischemic electrocardiogram abnormalities in an isolated heart model.

Batchu SN, Law E, Brocks DR, Falck JR, Seubert JM. Batchu SN, et al. Among authors: seubert jm. J Mol Cell Cardiol. 2009 Jan;46(1):67-74. doi: 10.1016/j.yjmcc.2008.09.711. Epub 2008 Oct 10. J Mol Cell Cardiol. 2009. PMID: 18973759

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Epoxyeicosatrienoic acids limit damage to mitochondrial function following stress in cardiac cells.

Katragadda D, Batchu SN, Cho WJ, Chaudhary KR, Falck JR, Seubert JM. Katragadda D, et al. Among authors: seubert jm. J Mol Cell Cardiol. 2009 Jun;46(6):867-75. doi: 10.1016/j.yjmcc.2009.02.028. Epub 2009 Mar 12. J Mol Cell Cardiol. 2009. PMID: 19285984

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Role of B-type natriuretic peptide in epoxyeicosatrienoic acid-mediated improved post-ischaemic recovery of heart contractile function.

Chaudhary KR, Batchu SN, Das D, Suresh MR, Falck JR, Graves JP, Zeldin DC, Seubert JM. Chaudhary KR, et al. Among authors: seubert jm. Cardiovasc Res. 2009 Jul 15;83(2):362-70. doi: 10.1093/cvr/cvp134. Epub 2009 Apr 28. Cardiovasc Res. 2009. PMID: 19401302 Free PMC article.

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Overexpression of CYP2J2 provides protection against doxorubicin-induced cardiotoxicity.

Zhang Y, El-Sikhry H, Chaudhary KR, Batchu SN, Shayeganpour A, Jukar TO, Bradbury JA, Graves JP, DeGraff LM, Myers P, Rouse DC, Foley J, Nyska A, Zeldin DC, Seubert JM. Zhang Y, et al. Among authors: seubert jm. Am J Physiol Heart Circ Physiol. 2009 Jul;297(1):H37-46. doi: 10.1152/ajpheart.00983.2008. Epub 2009 May 8. Am J Physiol Heart Circ Physiol. 2009. PMID: 19429816 Free PMC article.

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Inhibition of soluble epoxide hydrolase by trans-4- [4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid is protective against ischemia-reperfusion injury.

Chaudhary KR, Abukhashim M, Hwang SH, Hammock BD, Seubert JM. Chaudhary KR, et al. Among authors: seubert jm. J Cardiovasc Pharmacol. 2010 Jan;55(1):67-73. doi: 10.1097/FJC.0b013e3181c37d69. J Cardiovasc Pharmacol. 2010. PMID: 19834332 Free PMC article.

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Sonodynamic and photodynamic mechanisms of action of the novel hypocrellin sonosensitizer, SL017: mitochondrial cell death is attenuated by 11, 12-epoxyeicosatrienoic acid.

El-Sikhry HE, Miller GG, Madiyalakan MR, Seubert JM. El-Sikhry HE, et al. Among authors: seubert jm. Invest New Drugs. 2011 Dec;29(6):1328-36. doi: 10.1007/s10637-010-9495-2. Epub 2010 Jul 30. Invest New Drugs. 2011. PMID: 20676746

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Cardioprotective effect of a dual acting epoxyeicosatrienoic acid analogue towards ischaemia reperfusion injury.

Batchu SN, Lee SB, Qadhi RS, Chaudhary KR, El-Sikhry H, Kodela R, Falck JR, Seubert JM. Batchu SN, et al. Among authors: seubert jm. Br J Pharmacol. 2011 Feb;162(4):897-907. doi: 10.1111/j.1476-5381.2010.01093.x. Br J Pharmacol. 2011. PMID: 21039415 Free PMC article.

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