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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1976 1
1978 3
1981 2
1984 1
1985 1
1986 1
1987 5
1988 3
1989 6
1990 8
1991 3
1992 9
1993 4
1994 5
1995 4
1996 10
1997 7
1998 6
1999 8
2000 9
2001 7
2002 9
2003 10
2004 9
2005 15
2006 13
2007 8
2008 8
2009 5
2010 3
2011 10
2012 12
2013 16
2014 13
2015 20
2016 14
2017 14
2018 8
2019 12
2020 9
2021 13
2022 14
2023 10
2024 1

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325 results

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Page 1
Metformin-associated lactic acidosis: Current perspectives on causes and risk.
DeFronzo R, Fleming GA, Chen K, Bicsak TA. DeFronzo R, et al. Metabolism. 2016 Feb;65(2):20-9. doi: 10.1016/j.metabol.2015.10.014. Epub 2015 Oct 9. Metabolism. 2016. PMID: 26773926 Free article. Review.
Although metformin has become a drug of choice for the treatment of type 2 diabetes mellitus, some patients may not receive it owing to the risk of lactic acidosis. Metformin, along with other drugs in the biguanide class, increases plasma lactate levels in a plasma …
Although metformin has become a drug of choice for the treatment of type 2 diabetes mellitus, some patients may not receive it owing to the …
MELAS syndrome: Clinical manifestations, pathogenesis, and treatment options.
El-Hattab AW, Adesina AM, Jones J, Scaglia F. El-Hattab AW, et al. Mol Genet Metab. 2015 Sep-Oct;116(1-2):4-12. doi: 10.1016/j.ymgme.2015.06.004. Epub 2015 Jun 15. Mol Genet Metab. 2015. PMID: 26095523 Review.
Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is one of the most frequent maternally inherited mitochondrial disorders. MELAS syndrome is a multi-organ disease with broad manifestations including stroke-like episodes, de …
Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is one of the most frequent matern …
Biochemistry of exercise-induced metabolic acidosis.
Robergs RA, Ghiasvand F, Parker D. Robergs RA, et al. Am J Physiol Regul Integr Comp Physiol. 2004 Sep;287(3):R502-16. doi: 10.1152/ajpregu.00114.2004. Am J Physiol Regul Integr Comp Physiol. 2004. PMID: 15308499 Free article. Review.
On the basis of this explanation, if the rate of lactate production is high enough, the cellular proton buffering capacity can be exceeded, resulting in a decrease in cellular pH. These biochemical events have been termed lactic acidosis. The lactic acidos …
On the basis of this explanation, if the rate of lactate production is high enough, the cellular proton buffering capacity can be exceeded, …
Lactic Acidosis in Sepsis: It's Not All Anaerobic: Implications for Diagnosis and Management.
Suetrong B, Walley KR. Suetrong B, et al. Chest. 2016 Jan;149(1):252-61. doi: 10.1378/chest.15-1703. Epub 2016 Jan 6. Chest. 2016. PMID: 26378980 Review.

Increased blood lactate concentration (hyperlactatemia) and lactic acidosis (hyperlactatemia and serum pH < 7.35) are common in patients with severe sepsis or septic shock and are associated with significant morbidity and mortality. ...In this review, we i

…

Increased blood lactate concentration (hyperlactatemia) and lactic acidosis (hyperlactatemia and serum pH < 7.35) are commo

…
Fatigue in CKD: Epidemiology, Pathophysiology, and Treatment.
Gregg LP, Bossola M, Ostrosky-Frid M, Hedayati SS. Gregg LP, et al. Clin J Am Soc Nephrol. 2021 Sep;16(9):1445-1455. doi: 10.2215/CJN.19891220. Epub 2021 Apr 15. Clin J Am Soc Nephrol. 2021. PMID: 33858827 Free PMC article. Review.
Approximately 70% of patients with CKD report fatigue, with up to 25% reporting severe symptoms. Patient-reported fatigue is associated with death, dialysis initiation, and hospitalization among individuals with CKD. The pathophysiology is multifactorial and likely include …
Approximately 70% of patients with CKD report fatigue, with up to 25% reporting severe symptoms. Patient-reported fatigue is associat …
A Systematic Review of the Clinical Presentation, Diagnosis, and Treatment of Small Bowel Obstruction.
Rami Reddy SR, Cappell MS. Rami Reddy SR, et al. Curr Gastroenterol Rep. 2017 Jun;19(6):28. doi: 10.1007/s11894-017-0566-9. Curr Gastroenterol Rep. 2017. PMID: 28439845 Review.
Physical exam may reveal restlessness, acute illness, and signs of dehydration and sepsis, including tachycardia, pyrexia, dry mucous membranes, hypotension/orthostasis, abdominal distention, and hypoactive bowel sounds. Severe direct tenderness, involuntary guarding, abdo …
Physical exam may reveal restlessness, acute illness, and signs of dehydration and sepsis, including tachycardia, pyrexia, dry mucous membra …
[Cor pulmonale].
Aubry A, Paternot A, Vieillard-Baron A. Aubry A, et al. Rev Mal Respir. 2020 Mar;37(3):257-266. doi: 10.1016/j.rmr.2019.10.012. Epub 2020 Feb 19. Rev Mal Respir. 2020. PMID: 32088063 Review. French.
Acute cor pulmonale is usually secondary to an acute respiratory distress syndrome or to a pulmonary embolism but it can also be seen in primary lactic acidosis, a vaso-occlusive crisis in a patient with sickle cell anaemia, severe acute asthma, and entry of …
Acute cor pulmonale is usually secondary to an acute respiratory distress syndrome or to a pulmonary embolism but it can also be seen in pri …
[Metabolic acidosis].
Regolisti G, Fani F, Antoniotti R, Castellano G, Cremaschi E, Greco P, Parenti E, Morabito S, Sabatino A, Fiaccadori E. Regolisti G, et al. G Ital Nefrol. 2016 Nov-Dec;33(6):gin/33.6.1. G Ital Nefrol. 2016. PMID: 28134396 Free article. Review. Italian.
On this basis the bedside differential diagnosis of metabolic acidosis should be started from the identification of the two main subtypes of metabolic acidosis: the high anion gap metabolic acidosis and the normal anion gap (or hyperchloremic) metabolic ac …
On this basis the bedside differential diagnosis of metabolic acidosis should be started from the identification of the two main subt …
Lactic acid and exercise performance : culprit or friend?
Cairns SP. Cairns SP. Sports Med. 2006;36(4):279-91. doi: 10.2165/00007256-200636040-00001. Sports Med. 2006. PMID: 16573355 Review.
However, a number of recent high-profile papers have seriously challenged the 'lactic acid hypothesis'. In the 1990s, these findings mainly involved diminished negative effects of an induced acidosis in skinned or intact muscle fibres, at higher more physiological e …
However, a number of recent high-profile papers have seriously challenged the 'lactic acid hypothesis'. In the 1990s, these findings …
Review of Biguanide (Metformin) Toxicity.
Wang GS, Hoyte C. Wang GS, et al. J Intensive Care Med. 2019 Nov-Dec;34(11-12):863-876. doi: 10.1177/0885066618793385. Epub 2018 Aug 21. J Intensive Care Med. 2019. PMID: 30126348 Review.
The dominant source of metabolic acidosis associated with hyperlactatemia in metformin toxicity is the rapid cytosolic adenosine triphosphate (ATP) turnover when complex I is inhibited and oxidative phosphorylation cannot adequately recycle the vast quantity of H+ from ATP …
The dominant source of metabolic acidosis associated with hyperlactatemia in metformin toxicity is the rapid cytosolic adenosine trip …
325 results