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The long-term effects of capsaicin aqueous spray on the nasal mucosa.
Blom HM, Severijnen LA, Van Rijswijk JB, Mulder PG, Van Wijk RG, Fokkens WJ. Blom HM, et al. Among authors: severijnen la. Clin Exp Allergy. 1998 Nov;28(11):1351-8. doi: 10.1046/j.1365-2222.1998.00421.x. Clin Exp Allergy. 1998. PMID: 9824407 Clinical Trial.
Preventive treatment of intranasal fluticasone propionate reduces cytokine mRNA expressing cells before and during a single nasal allergen provocation.
Kleinjan A, Holm AF, Dijkstra MD, Boks SS, Severijnen L, Mulder PG, Fokkens WJ. Kleinjan A, et al. Among authors: severijnen l. Clin Exp Allergy. 2000 Oct;30(10):1476-85. doi: 10.1046/j.1365-2222.2000.00904.x. Clin Exp Allergy. 2000. PMID: 10998026 Clinical Trial.
Fluticasone propionate aqueous nasal spray reduces inflammatory cells in unchallenged allergic nasal mucosa: effects of single allergen challenge.
Holm A, Dijkstra M, Kleinjan A, Severijnen LA, Boks S, Mulder P, Fokkens W. Holm A, et al. Among authors: severijnen la. J Allergy Clin Immunol. 2001 Apr;107(4):627-33. doi: 10.1067/mai.2001.113520. J Allergy Clin Immunol. 2001. PMID: 11295650 Clinical Trial.
Increase in IL-8, IL-10, IL-13, and RANTES mRNA levels (in situ hybridization) in the nasal mucosa after nasal allergen provocation.
KleinJan A, Dijkstra MD, Boks SS, Severijnen LA, Mulder PG, Fokkens WJ. KleinJan A, et al. Among authors: severijnen la. J Allergy Clin Immunol. 1999 Mar;103(3 Pt 1):441-50. doi: 10.1016/s0091-6749(99)70469-0. J Allergy Clin Immunol. 1999. PMID: 10069878
Morphological changes in muscle tissue of patients with infantile Pompe's disease receiving enzyme replacement therapy.
Winkel LP, Kamphoven JH, van den Hout HJ, Severijnen LA, van Doorn PA, Reuser AJ, van der Ploeg AT. Winkel LP, et al. Among authors: severijnen la. Muscle Nerve. 2003 Jun;27(6):743-51. doi: 10.1002/mus.10381. Muscle Nerve. 2003. PMID: 12766987
Elevated Fmr1 mRNA levels and reduced protein expression in a mouse model with an unmethylated Fragile X full mutation.
Brouwer JR, Mientjes EJ, Bakker CE, Nieuwenhuizen IM, Severijnen LA, Van der Linde HC, Nelson DL, Oostra BA, Willemsen R. Brouwer JR, et al. Among authors: severijnen la. Exp Cell Res. 2007 Jan 15;313(2):244-53. doi: 10.1016/j.yexcr.2006.10.002. Epub 2006 Oct 13. Exp Cell Res. 2007. PMID: 17150213 Free PMC article.
The generation of a conditional Fmr1 knock out mouse model to study Fmrp function in vivo.
Mientjes EJ, Nieuwenhuizen I, Kirkpatrick L, Zu T, Hoogeveen-Westerveld M, Severijnen L, Rifé M, Willemsen R, Nelson DL, Oostra BA. Mientjes EJ, et al. Among authors: severijnen l. Neurobiol Dis. 2006 Mar;21(3):549-55. doi: 10.1016/j.nbd.2005.08.019. Epub 2005 Oct 26. Neurobiol Dis. 2006. PMID: 16257225
Refining the Spectrum of Neuronal Intranuclear Inclusion Disease: A Case Report.
Cupidi C, Dijkstra AA, Melhem S, Vernooij MW, Severijnen LA, Hukema RK, Rozemuller AJM, Neumann M, van Swieten JC, Seelaar H. Cupidi C, et al. Among authors: severijnen la. J Neuropathol Exp Neurol. 2019 Jul 1;78(7):665-670. doi: 10.1093/jnen/nlz043. J Neuropathol Exp Neurol. 2019. PMID: 31150092
HR23B pathology preferentially co-localizes with p62, pTDP-43 and poly-GA in C9ORF72-linked frontotemporal dementia and amyotrophic lateral sclerosis.
Riemslagh FW, Lans H, Seelaar H, Severijnen LWFM, Melhem S, Vermeulen W, Aronica E, Pasterkamp RJ, van Swieten JC, Willemsen R. Riemslagh FW, et al. Acta Neuropathol Commun. 2019 Mar 13;7(1):39. doi: 10.1186/s40478-019-0694-6. Acta Neuropathol Commun. 2019. PMID: 30867060 Free PMC article.
Astroglial-targeted expression of the fragile X CGG repeat premutation in mice yields RAN translation, motor deficits and possible evidence for cell-to-cell propagation of FXTAS pathology.
Wenzel HJ, Murray KD, Haify SN, Hunsaker MR, Schwartzer JJ, Kim K, La Spada AR, Sopher BL, Hagerman PJ, Raske C, Severijnen LWFM, Willemsen R, Hukema RK, Berman RF. Wenzel HJ, et al. Acta Neuropathol Commun. 2019 Feb 26;7(1):27. doi: 10.1186/s40478-019-0677-7. Acta Neuropathol Commun. 2019. PMID: 30808398 Free PMC article.
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