Severinsen K - Search Results

1

Binding of the amphetamine-like 1-phenyl-piperazine to monoamine transporters.

Severinsen K, Kraft JF, Koldsø H, Vinberg KA, Rothman RB, Partilla JS, Wiborg O, Blough B, Schiøtt B, Sinning S. Severinsen K, et al. ACS Chem Neurosci. 2012 Sep 19;3(9):693-705. doi: 10.1021/cn300040f. Epub 2012 Jun 10. ACS Chem Neurosci. 2012. PMID: 23019496 Free PMC article.

2

Characterisation of the zebrafish serotonin transporter functionally links TM10 to the ligand binding site.

Severinsen K, Sinning S, Müller HK, Wiborg O. Severinsen K, et al. J Neurochem. 2008 Jun;105(5):1794-805. doi: 10.1111/j.1471-4159.2008.05285.x. Epub 2008 Feb 7. J Neurochem. 2008. PMID: 18266934 Free article.

3

Binding of serotonin to the human serotonin transporter. Molecular modeling and experimental validation.

Celik L, Sinning S, Severinsen K, Hansen CG, Møller MS, Bols M, Wiborg O, Schiøtt B. Celik L, et al. Among authors: severinsen k. J Am Chem Soc. 2008 Mar 26;130(12):3853-65. doi: 10.1021/ja076403h. Epub 2008 Mar 4. J Am Chem Soc. 2008. PMID: 18314975

4

Binding and orientation of tricyclic antidepressants within the central substrate site of the human serotonin transporter.

Sinning S, Musgaard M, Jensen M, Severinsen K, Celik L, Koldsø H, Meyer T, Bols M, Jensen HH, Schiøtt B, Wiborg O. Sinning S, et al. Among authors: severinsen k. J Biol Chem. 2010 Mar 12;285(11):8363-74. doi: 10.1074/jbc.M109.045401. Epub 2009 Nov 30. J Biol Chem. 2010. PMID: 19948720 Free PMC article.

5

Binding of mazindol and analogs to the human serotonin and dopamine transporters.

Severinsen K, Koldsø H, Thorup KA, Schjøth-Eskesen C, Møller PT, Wiborg O, Jensen HH, Sinning S, Schiøtt B. Severinsen K, et al. Mol Pharmacol. 2014 Feb;85(2):208-17. doi: 10.1124/mol.113.088922. Epub 2013 Nov 8. Mol Pharmacol. 2014. PMID: 24214825

6

The two enantiomers of citalopram bind to the human serotonin transporter in reversed orientations.

Koldsø H, Severinsen K, Tran TT, Celik L, Jensen HH, Wiborg O, Schiøtt B, Sinning S. Koldsø H, et al. Among authors: severinsen k. J Am Chem Soc. 2010 Feb 3;132(4):1311-22. doi: 10.1021/ja906923j. J Am Chem Soc. 2010. PMID: 20055463 Free article.

7

A dualistic conformational response to substrate binding in the human serotonin transporter reveals a high affinity state for serotonin.

Bjerregaard H, Severinsen K, Said S, Wiborg O, Sinning S. Bjerregaard H, et al. Among authors: severinsen k. J Biol Chem. 2015 Mar 20;290(12):7747-55. doi: 10.1074/jbc.M114.573477. Epub 2015 Jan 22. J Biol Chem. 2015. PMID: 25614630 Free PMC article.

8

A conserved leucine occupies the empty substrate site of LeuT in the Na(+)-free return state.

Malinauskaite L, Said S, Sahin C, Grouleff J, Shahsavar A, Bjerregaard H, Noer P, Severinsen K, Boesen T, Schiøtt B, Sinning S, Nissen P. Malinauskaite L, et al. Among authors: severinsen k. Nat Commun. 2016 May 25;7:11673. doi: 10.1038/ncomms11673. Nat Commun. 2016. PMID: 27221344 Free PMC article.

9

Cholesterol binding to a conserved site modulates the conformation, pharmacology, and transport kinetics of the human serotonin transporter.

Laursen L, Severinsen K, Kristensen KB, Periole X, Overby M, Müller HK, Schiøtt B, Sinning S. Laursen L, et al. Among authors: severinsen k. J Biol Chem. 2018 Mar 9;293(10):3510-3523. doi: 10.1074/jbc.M117.809046. Epub 2018 Jan 19. J Biol Chem. 2018. PMID: 29352106 Free PMC article.

10

Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses.

Holm CK, Rahbek SH, Gad HH, Bak RO, Jakobsen MR, Jiang Z, Hansen AL, Jensen SK, Sun C, Thomsen MK, Laustsen A, Nielsen CG, Severinsen K, Xiong Y, Burdette DL, Hornung V, Lebbink RJ, Duch M, Fitzgerald KA, Bahrami S, Mikkelsen JG, Hartmann R, Paludan SR. Holm CK, et al. Among authors: severinsen k. Nat Commun. 2016 Feb 19;7:10680. doi: 10.1038/ncomms10680. Nat Commun. 2016. PMID: 26893169 Free PMC article.

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