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Page 1
Hydrophobic CDR3 residues promote the development of self-reactive T cells.
Stadinski BD, Shekhar K, Gómez-Touriño I, Jung J, Sasaki K, Sewell AK, Peakman M, Chakraborty AK, Huseby ES. Stadinski BD, et al. Among authors: sewell ak. Nat Immunol. 2016 Aug;17(8):946-55. doi: 10.1038/ni.3491. Epub 2016 Jun 27. Nat Immunol. 2016. PMID: 27348411 Free PMC article.
CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope.
Skowera A, Ellis RJ, Varela-Calviño R, Arif S, Huang GC, Van-Krinks C, Zaremba A, Rackham C, Allen JS, Tree TI, Zhao M, Dayan CM, Sewell AK, Unger WW, Drijfhout JW, Ossendorp F, Roep BO, Peakman M. Skowera A, et al. Among authors: sewell ak. J Clin Invest. 2008 Oct;118(10):3390-402. doi: 10.1172/JCI35449. J Clin Invest. 2008. PMID: 18802479 Free PMC article.
Protein kinase inhibitors substantially improve the physical detection of T-cells with peptide-MHC tetramers.
Lissina A, Ladell K, Skowera A, Clement M, Edwards E, Seggewiss R, van den Berg HA, Gostick E, Gallagher K, Jones E, Melenhorst JJ, Godkin AJ, Peakman M, Price DA, Sewell AK, Wooldridge L. Lissina A, et al. Among authors: sewell ak. J Immunol Methods. 2009 Jan 1;340(1):11-24. doi: 10.1016/j.jim.2008.09.014. Epub 2008 Oct 16. J Immunol Methods. 2009. PMID: 18929568 Free PMC article.
Tricks with tetramers: how to get the most from multimeric peptide-MHC.
Wooldridge L, Lissina A, Cole DK, van den Berg HA, Price DA, Sewell AK. Wooldridge L, et al. Among authors: sewell ak. Immunology. 2009 Feb;126(2):147-64. doi: 10.1111/j.1365-2567.2008.02848.x. Immunology. 2009. PMID: 19125886 Free PMC article. Review.
A single autoimmune T cell receptor recognizes more than a million different peptides.
Wooldridge L, Ekeruche-Makinde J, van den Berg HA, Skowera A, Miles JJ, Tan MP, Dolton G, Clement M, Llewellyn-Lacey S, Price DA, Peakman M, Sewell AK. Wooldridge L, et al. Among authors: sewell ak. J Biol Chem. 2012 Jan 6;287(2):1168-77. doi: 10.1074/jbc.M111.289488. Epub 2011 Nov 18. J Biol Chem. 2012. PMID: 22102287 Free PMC article.
Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes.
Bulek AM, Cole DK, Skowera A, Dolton G, Gras S, Madura F, Fuller A, Miles JJ, Gostick E, Price DA, Drijfhout JW, Knight RR, Huang GC, Lissin N, Molloy PE, Wooldridge L, Jakobsen BK, Rossjohn J, Peakman M, Rizkallah PJ, Sewell AK. Bulek AM, et al. Among authors: sewell ak. Nat Immunol. 2012 Jan 15;13(3):283-9. doi: 10.1038/ni.2206. Nat Immunol. 2012. PMID: 22245737 Free PMC article.
The molecular determinants of CD8 co-receptor function.
Cole DK, Laugel B, Clement M, Price DA, Wooldridge L, Sewell AK. Cole DK, et al. Among authors: sewell ak. Immunology. 2012 Oct;137(2):139-48. doi: 10.1111/j.1365-2567.2012.03625.x. Immunology. 2012. PMID: 22804746 Free PMC article. Review.
Why must T cells be cross-reactive?
Sewell AK. Sewell AK. Nat Rev Immunol. 2012 Sep;12(9):669-77. doi: 10.1038/nri3279. Nat Rev Immunol. 2012. PMID: 22918468 Free PMC article. Review.
212 results