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1996 2
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2015 1
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2019 9
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Sex Differences in the Genetic Architecture of Alzheimer's Disease.
Dumitrescu L, Mayeda ER, Sharman K, Moore AM, Hohman TJ. Dumitrescu L, et al. Curr Genet Med Rep. 2019 Mar;7(1):13-21. doi: 10.1007/s40142-019-0157-1. Epub 2019 Jan 21. Curr Genet Med Rep. 2019. PMID: 31360619 Free PMC article.
PURPOSE OF REVIEW: Summarize sex-specific contributors to the genetic architecture of Alzheimer's disease (AD). ...SUMMARY: There is a lack of comprehensive assessments of sex differences in genome-wide analyses of AD and a need fo …
PURPOSE OF REVIEW: Summarize sex-specific contributors to the genetic architecture of Alzheimer's disease
Sex differences in the genetic predictors of Alzheimer's pathology.
Dumitrescu L, Barnes LL, Thambisetty M, Beecham G, Kunkle B, Bush WS, Gifford KA, Chibnik LB, Mukherjee S, De Jager PL, Kukull W, Crane PK, Resnick SM, Keene CD, Montine TJ, Schellenberg GD, Deming Y, Chao MJ, Huentelman M, Martin ER, Hamilton-Nelson K, Shaw LM, Trojanowski JQ, Peskind ER, Cruchaga C, Pericak-Vance MA, Goate AM, Cox NJ, Haines JL, Zetterberg H, Blennow K, Larson EB, Johnson SC, Albert M; Alzheimer’s Disease Genetics Consortium and the Alzheimer’s Disease Neuroimaging Initiative; Bennett DA, Schneider JA, Jefferson AL, Hohman TJ. Dumitrescu L, et al. Brain. 2019 Sep 1;142(9):2581-2589. doi: 10.1093/brain/awz206. Brain. 2019. PMID: 31497858 Free PMC article.
However, despite evidence of sex differences in Alzheimer's disease risk, sex-stratified models have not been incorporated into previous GWAS analyses. We looked for sex-specific genetic associations with Alzheimer' …
However, despite evidence of sex differences in Alzheimer's disease risk, sex-stratified models ha …
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.
Kanoni S, Graham SE, Wang Y, Surakka I, Ramdas S, Zhu X, Clarke SL, Bhatti KF, Vedantam S, Winkler TW, Locke AE, Marouli E, Zajac GJM, Wu KH, Ntalla I, Hui Q, Klarin D, Hilliard AT, Wang Z, Xue C, Thorleifsson G, Helgadottir A, Gudbjartsson DF, Holm H, Olafsson I, Hwang MY, Han S, Akiyama M, Sakaue S, Terao C, Kanai M, Zhou W, Brumpton BM, Rasheed H, Havulinna AS, Veturi Y, Pacheco JA, Rosenthal EA, Lingren T, Feng Q, Kullo IJ, Narita A, Takayama J, Martin HC, Hunt KA, Trivedi B, Haessler J, Giulianini F, Bradford Y, Miller JE, Campbell A, Lin K, Millwood IY, Rasheed A, Hindy G, Faul JD, Zhao W, Weir DR, Turman C, Huang H, Graff M, Choudhury A, Sengupta D, Mahajan A, Brown MR, Zhang W, Yu K, Schmidt EM, Pandit A, Gustafsson S, Yin X, Luan J, Zhao JH, Matsuda F, Jang HM, Yoon K, Medina-Gomez C, Pitsillides A, Hottenga JJ, Wood AR, Ji Y, Gao Z, Haworth S, Yousri NA, Mitchell RE, Chai JF, Aadahl M, Bjerregaard AA, Yao J, Manichaikul A, Hwu CM, Hung YJ, Warren HR, Ramirez J, Bork-Jensen J, Kårhus LL, Goel A, Sabater-Lleal M, Noordam R, Mauro P, Matteo F, McDaid AF, Marques-Vidal P, Wielscher M, Trompet S, Sattar N, Møllehave LT, Munz M, Zeng L, Huang J, Yang B, Poveda A, Kurbasic A, L… See abstract for full author list ➔ Kanoni S, et al. Genome Biol. 2022 Dec 27;23(1):268. doi: 10.1186/s13059-022-02837-1. Genome Biol. 2022. PMID: 36575460 Free PMC article.
BACKGROUND: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. ...Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic …
BACKGROUND: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. ...Finally, we repo …
Sex-specific genetic predictors of Alzheimer's disease biomarkers.
Deming Y, Dumitrescu L, Barnes LL, Thambisetty M, Kunkle B, Gifford KA, Bush WS, Chibnik LB, Mukherjee S, De Jager PL, Kukull W, Huentelman M, Crane PK, Resnick SM, Keene CD, Montine TJ, Schellenberg GD, Haines JL, Zetterberg H, Blennow K, Larson EB, Johnson SC, Albert M, Moghekar A, Del Aguila JL, Fernandez MV, Budde J, Hassenstab J, Fagan AM, Riemenschneider M, Petersen RC, Minthon L, Chao MJ, Van Deerlin VM, Lee VM, Shaw LM, Trojanowski JQ, Peskind ER, Li G, Davis LK, Sealock JM, Cox NJ; Alzheimer’s Disease Neuroimaging Initiative (ADNI); Alzheimer Disease Genetics Consortium (ADGC); Goate AM, Bennett DA, Schneider JA, Jefferson AL, Cruchaga C, Hohman TJ. Deming Y, et al. Acta Neuropathol. 2018 Dec;136(6):857-872. doi: 10.1007/s00401-018-1881-4. Epub 2018 Jul 2. Acta Neuropathol. 2018. PMID: 29967939 Free PMC article.
Cerebrospinal fluid (CSF) levels of amyloid-beta 42 (Abeta42) and tau have been evaluated as endophenotypes in Alzheimer's disease (AD) genetic studies. Although there are sex differences in AD risk, sex differences have not …
Cerebrospinal fluid (CSF) levels of amyloid-beta 42 (Abeta42) and tau have been evaluated as endophenotypes in Alzheimer's
Predictors of Heterogeneity in Cognitive Function: APOE-e4, Sex, Education, Depression, and Vascular Risk.
MacAulay RK, Halpin A, Cohen AS, Calamia M, Boeve A, Zhang L, Brouillette RM, Foil HC, Bruce-Keller A, Keller JN. MacAulay RK, et al. Arch Clin Neuropsychol. 2020 Aug 28;35(6):660-670. doi: 10.1093/arclin/acaa014. Arch Clin Neuropsychol. 2020. PMID: 32129455
RESULTS: The hypothesized model(s) provided an adequate fit for the data. Sex differences in cognition, depression, and vascular risk were found. ...Future research is needed to determine whether the multifactorial risk effects on cognition vary by sex. Preci …
RESULTS: The hypothesized model(s) provided an adequate fit for the data. Sex differences in cognition, depression, and vascul …
Identification of Successful Cognitive Aging in the Alzheimer's Disease Neuroimaging Initiative Study.
Lin FV, Wang X, Wu R, Rebok GW, Chapman BP; Alzheimer’s Disease Neuroimaging Initiative. Lin FV, et al. J Alzheimers Dis. 2017;59(1):101-111. doi: 10.3233/JAD-161278. J Alzheimers Dis. 2017. PMID: 28582857 Free PMC article.
Potential individual-level predictors that were related to Alzheimer's disease pathology or genetic risk, neurodegeneration, and vascular risks were collected at baseline. ...Sex, apolipoprotein E allele 4, amyloid-beta1-42, and t-tau sig …
Potential individual-level predictors that were related to Alzheimer's disease pathology or genetic risk, …
Examination of race and gender differences in predictors of neuropsychological decline and development of Alzheimer's disease.
Johnson EEH, Alexander C, Lee GJ, Angers K, Ndiaye D, Suhr J. Johnson EEH, et al. Clin Neuropsychol. 2022 Feb;36(2):327-352. doi: 10.1080/13854046.2021.1940299. Epub 2021 Jul 5. Clin Neuropsychol. 2022. PMID: 34218735 Free PMC article.
ObjectiveBlack adults are diagnosed with Alzheimer's disease (AD) at higher rates than White adults. Biopsychosocial risk factors that differentially affect individuals by race, including health, education, and APOE e4, may explain these findings. ...We exami …
ObjectiveBlack adults are diagnosed with Alzheimer's disease (AD) at higher rates than White adults. Biopsychosocial ri …
Sex-driven modifiers of Alzheimer risk: A multimodality brain imaging study.
Rahman A, Schelbaum E, Hoffman K, Diaz I, Hristov H, Andrews R, Jett S, Jackson H, Lee A, Sarva H, Pahlajani S, Matthews D, Dyke J, de Leon MJ, Isaacson RS, Brinton RD, Mosconi L. Rahman A, et al. Neurology. 2020 Jul 14;95(2):e166-e178. doi: 10.1212/WNL.0000000000009781. Epub 2020 Jun 24. Neurology. 2020. PMID: 32580974 Free PMC article.
OBJECTIVE: To investigate sex differences in late-onset Alzheimer disease (AD) risks by means of multimodality brain biomarkers (beta-amyloid load via (11)C-Pittsburgh compound B [PiB] PET, neurodegeneration via (18)F-fluorodeoxyglucose [FDG] PET and s …
OBJECTIVE: To investigate sex differences in late-onset Alzheimer disease (AD) risks by means of multimodality b …
APOE epsilon4 carrier status and sex differentiate rates of cognitive decline in early- and late-onset Alzheimer's disease.
Polsinelli AJ, Logan PE, Lane KA, Manchella MK, Nemes S, Sanjay AB, Gao S, Apostolova LG. Polsinelli AJ, et al. Alzheimers Dement. 2023 May;19(5):1983-1993. doi: 10.1002/alz.12831. Epub 2022 Nov 17. Alzheimers Dement. 2023. PMID: 36394443 Free PMC article.
BACKGROUND: We studied the effect of apolipoprotein E (APOE) epsilon4 status and sex on rates of cognitive decline in early- (EO) and late- (LO) onset Alzheimer's disease (AD). ...HIGHLIGHTS: Apolipoprotein E (APOE) epsilon4 carrier status and sex
BACKGROUND: We studied the effect of apolipoprotein E (APOE) epsilon4 status and sex on rates of cognitive decline in early- (EO) and …
APOΕ4 lowers energy expenditure in females and impairs glucose oxidation by increasing flux through aerobic glycolysis.
Farmer BC, Williams HC, Devanney NA, Piron MA, Nation GK, Carter DJ, Walsh AE, Khanal R, Young LEA, Kluemper JC, Hernandez G, Allenger EJ, Mooney R, Golden LR, Smith CT, Brandon JA, Gupta VA, Kern PA, Gentry MS, Morganti JM, Sun RC, Johnson LA. Farmer BC, et al. Mol Neurodegener. 2021 Sep 6;16(1):62. doi: 10.1186/s13024-021-00483-y. Mol Neurodegener. 2021. PMID: 34488832 Free PMC article.
BACKGROUND: Cerebral glucose hypometabolism is consistently observed in individuals with Alzheimer's disease (AD), as well as in young cognitively normal carriers of the epsilon4 allele of Apolipoprotein E (APOE), the strongest genetic predictor
BACKGROUND: Cerebral glucose hypometabolism is consistently observed in individuals with Alzheimer's disease (AD), as w …
42 results