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Sex-specific genetic predictors of Alzheimer's disease biomarkers.
Deming Y, Dumitrescu L, Barnes LL, Thambisetty M, Kunkle B, Gifford KA, Bush WS, Chibnik LB, Mukherjee S, De Jager PL, Kukull W, Huentelman M, Crane PK, Resnick SM, Keene CD, Montine TJ, Schellenberg GD, Haines JL, Zetterberg H, Blennow K, Larson EB, Johnson SC, Albert M, Moghekar A, Del Aguila JL, Fernandez MV, Budde J, Hassenstab J, Fagan AM, Riemenschneider M, Petersen RC, Minthon L, Chao MJ, Van Deerlin VM, Lee VM, Shaw LM, Trojanowski JQ, Peskind ER, Li G, Davis LK, Sealock JM, Cox NJ; Alzheimer’s Disease Neuroimaging Initiative (ADNI); Alzheimer Disease Genetics Consortium (ADGC); Goate AM, Bennett DA, Schneider JA, Jefferson AL, Cruchaga C, Hohman TJ. Deming Y, et al. Acta Neuropathol. 2018 Dec;136(6):857-872. doi: 10.1007/s00401-018-1881-4. Epub 2018 Jul 2. Acta Neuropathol. 2018. PMID: 29967939 Free PMC article.
Cerebrospinal fluid (CSF) levels of amyloid-beta 42 (Abeta42) and tau have been evaluated as endophenotypes in Alzheimer's disease (AD) genetic studies. Although there are sex differences in AD risk, sex differences have not been evaluated in geneti
Cerebrospinal fluid (CSF) levels of amyloid-beta 42 (Abeta42) and tau have been evaluated as endophenotypes in Alzheimer's
Sex differences in the genetic predictors of Alzheimer's pathology.
Dumitrescu L, Barnes LL, Thambisetty M, Beecham G, Kunkle B, Bush WS, Gifford KA, Chibnik LB, Mukherjee S, De Jager PL, Kukull W, Crane PK, Resnick SM, Keene CD, Montine TJ, Schellenberg GD, Deming Y, Chao MJ, Huentelman M, Martin ER, Hamilton-Nelson K, Shaw LM, Trojanowski JQ, Peskind ER, Cruchaga C, Pericak-Vance MA, Goate AM, Cox NJ, Haines JL, Zetterberg H, Blennow K, Larson EB, Johnson SC, Albert M; Alzheimer’s Disease Genetics Consortium and the Alzheimer’s Disease Neuroimaging Initiative; Bennett DA, Schneider JA, Jefferson AL, Hohman TJ. Dumitrescu L, et al. Brain. 2019 Sep 1;142(9):2581-2589. doi: 10.1093/brain/awz206. Brain. 2019. PMID: 31497858 Free PMC article.
Autopsy measures of Alzheimer's disease neuropathology have been leveraged as endophenotypes in previous genome-wide association studies (GWAS). ...We looked for sex-specific genetic associations with Alzheimer's disease
Autopsy measures of Alzheimer's disease neuropathology have been leveraged as endophenotypes in previous genome-wide as …
Sex Differences in the Genetic Architecture of Alzheimer's Disease.
Dumitrescu L, Mayeda ER, Sharman K, Moore AM, Hohman TJ. Dumitrescu L, et al. Curr Genet Med Rep. 2019 Mar;7(1):13-21. doi: 10.1007/s40142-019-0157-1. Epub 2019 Jan 21. Curr Genet Med Rep. 2019. PMID: 31360619 Free PMC article.
PURPOSE OF REVIEW: Summarize sex-specific contributors to the genetic architecture of Alzheimer's disease (AD). ...Ultimately, sex-specific genetic association studies represent a logical first step towards precision …
PURPOSE OF REVIEW: Summarize sex-specific contributors to the genetic architecture of Alzheimer's dise
Memory Resilience to Alzheimer's Genetic Risk: Sex Effects in Predictor Profiles.
McDermott KL, McFall GP, Andrews SJ, Anstey KJ, Dixon RA. McDermott KL, et al. J Gerontol B Psychol Sci Soc Sci. 2017 Oct 1;72(6):937-946. doi: 10.1093/geronb/gbw161. J Gerontol B Psychol Sci Soc Sci. 2017. PMID: 28025282 Free PMC article.
OBJECTIVES: Apolipoprotein E (APOE) e4 and Clusterin (CLU) C alleles are risk factors for Alzheimer's disease (AD) and episodic memory (EM) decline. Memory resilience occurs when genetically at-risk adults perform at high and sustained levels. ...Se
OBJECTIVES: Apolipoprotein E (APOE) e4 and Clusterin (CLU) C alleles are risk factors for Alzheimer's disease (AD) and …
Leveraging electronic health records and knowledge networks for Alzheimer's disease prediction and sex-specific biological insights.
Tang AS, Rankin KP, Cerono G, Miramontes S, Mills H, Roger J, Zeng B, Nelson C, Soman K, Woldemariam S, Li Y, Lee A, Bove R, Glymour M, Aghaeepour N, Oskotsky TT, Miller Z, Allen IE, Sanders SJ, Baranzini S, Sirota M. Tang AS, et al. Nat Aging. 2024 Feb 21. doi: 10.1038/s43587-024-00573-8. Online ahead of print. Nat Aging. 2024. PMID: 38383858
Identification of Alzheimer's disease (AD) onset risk can facilitate interventions before irreversible disease progression. ...Knowledge networks highlight shared genes between multiple top predictors and AD (for example, APOE, ACTB, IL6 and INS …
Identification of Alzheimer's disease (AD) onset risk can facilitate interventions before irreversible disease p …
Trajectories of depressive and anxiety symptoms in older adults: a 6-year prospective cohort study.
Holmes SE, Esterlis I, Mazure CM, Lim YY, Ames D, Rainey-Smith S, Fowler C, Ellis K, Martins RN, Salvado O, Doré V, Villemagne VL, Rowe CC, Laws SM, Masters CL, Pietrzak RH, Maruff P; Australian Imaging, Biomarkers and Lifestyle Research Group. Holmes SE, et al. Int J Geriatr Psychiatry. 2018 Feb;33(2):405-413. doi: 10.1002/gps.4761. Epub 2017 Jul 24. Int J Geriatr Psychiatry. 2018. PMID: 28736899 Free PMC article.
OBJECTIVE: Depressive and anxiety symptoms are common in older adults, significantly affect quality of life, and are risk factors for Alzheimer's disease. We sought to identify the determinants of predominant trajectories of depressive and anxiety symptoms in …
OBJECTIVE: Depressive and anxiety symptoms are common in older adults, significantly affect quality of life, and are risk factors for Alz
Magnetic Resonance Volumetry: Prediction of Subjective Memory Complaints and Mild Cognitive Impairment, and Associations with Genetic and Cardiovascular Risk Factors.
Rogne S, Vangberg T, Eldevik P, Wikran G, Mathiesen EB, Schirmer H. Rogne S, et al. Dement Geriatr Cogn Dis Extra. 2016 Nov 25;6(3):529-540. doi: 10.1159/000450885. eCollection 2016 Sep-Dec. Dement Geriatr Cogn Dis Extra. 2016. PMID: 28101099 Free PMC article.
BACKGROUND/AIMS: Subjective memory complaints (SMC) are strong predictors of mild cognitive impairment (MCI) and subsequent Alzheimer's disease. Our aims were to see if fully automated cerebral MR volume measurements could distinguish subjects with SMC …
BACKGROUND/AIMS: Subjective memory complaints (SMC) are strong predictors of mild cognitive impairment (MCI) and subsequent Alzhei
Psychological and neurobiological mechanisms involved in the relationship between loneliness and cognitive decline in older adults.
Dabiri S, Mwendwa DT, Campbell A. Dabiri S, et al. Brain Behav Immun. 2024 Feb;116:10-21. doi: 10.1016/j.bbi.2023.11.034. Epub 2023 Nov 24. Brain Behav Immun. 2024. PMID: 38008386
These pathways included depressive symptoms, total gray matter volume, and conditional analyses of pro-inflammatory cytokines and brain-derived neurotrophic factor (BDNF) expression. Second, it examined loneliness as a predictor of mild cognitive impairment (MCI) and Al
These pathways included depressive symptoms, total gray matter volume, and conditional analyses of pro-inflammatory cytokines and brain-deri …