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Daunomycin- and adriamycin-N-(2-hydroxypropyl)methacrylamide copolymer conjugates; toxicity reduction by improved drug-delivery.
Seymour LW, Duncan R, Kopeckov√° P, Kopecek J. Seymour LW, et al. Cancer Treat Rev. 1987 Dec;14(3-4):319-27. doi: 10.1016/0305-7372(87)90024-7. Cancer Treat Rev. 1987. PMID: 3326668 Review. No abstract available.
The pharmacokinetics of polymer-bound adriamycin.
Seymour LW, Ulbrich K, Strohalm J, Kopecek J, Duncan R. Seymour LW, et al. Biochem Pharmacol. 1990 Mar 15;39(6):1125-31. doi: 10.1016/0006-2952(90)90293-t. Biochem Pharmacol. 1990. PMID: 2322298
Effect of molecular weight (Mw) of N-(2-hydroxypropyl)methacrylamide copolymers on body distribution and rate of excretion after subcutaneous, intraperitoneal, and intravenous administration to rats.
Seymour LW, Duncan R, Strohalm J, Kopecek J. Seymour LW, et al. J Biomed Mater Res. 1987 Nov;21(11):1341-58. doi: 10.1002/jbm.820211106. J Biomed Mater Res. 1987. PMID: 3680316
Passive tumor targeting of soluble macromolecules and drug conjugates.
Seymour LW. Seymour LW. Crit Rev Ther Drug Carrier Syst. 1992;9(2):135-87. Crit Rev Ther Drug Carrier Syst. 1992. PMID: 1386002 Review.
The effect of size of polystyrene particles on their retention within the rat peritoneal compartment, and on their interaction with rat peritoneal macrophages in vitro.
Seymour L, Schacht E, Duncan R. Seymour L, et al. Cell Biol Int Rep. 1991 Apr;15(4):277-86. doi: 10.1016/0309-1651(91)90166-g. Cell Biol Int Rep. 1991. PMID: 1878974
Reduced cardiotoxicity of doxorubicin given in the form of N-(2-hydroxypropyl)methacrylamide conjugates: and experimental study in the rat.
Yeung TK, Hopewell JW, Simmonds RH, Seymour LW, Duncan R, Bellini O, Grandi M, Spreafico F, Strohalm J, Ulbrich K. Yeung TK, et al. Cancer Chemother Pharmacol. 1991;29(2):105-11. doi: 10.1007/BF00687318. Cancer Chemother Pharmacol. 1991. PMID: 1760851
Hepatic drug targeting: phase I evaluation of polymer-bound doxorubicin.
Seymour LW, Ferry DR, Anderson D, Hesslewood S, Julyan PJ, Poyner R, Doran J, Young AM, Burtles S, Kerr DJ; Cancer Research Campaign Phase I/II Clinical Trials committee. Seymour LW, et al. J Clin Oncol. 2002 Mar 15;20(6):1668-76. doi: 10.1200/JCO.2002.20.6.1668. J Clin Oncol. 2002. PMID: 11896118 Clinical Trial.
P-selectin dependent targeting to inflamed endothelium of recombinant P-selectin glycoprotein ligand-1 immunoglobulin chimera-coated poly[N-(2-hydroxypropyl) methacrylamide]-DNA polyplexes in vivo visualised by intravital microscopy.
Newman CM, Crosdale DJ, Fisher KD, Briggs SS, Norman KE, Seymour LW, Hellewell PG. Newman CM, et al. J Gene Med. 2009 Apr;11(4):326-34. doi: 10.1002/jgm.1294. J Gene Med. 2009. PMID: 19219895
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