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"Submergence" of Western equine encephalitis virus: Evidence of positive selection argues against genetic drift and fitness reductions.
Bergren NA, Haller S, Rossi SL, Seymour RL, Huang J, Miller AL, Bowen RA, Hartman DA, Brault AC, Weaver SC. Bergren NA, et al. Among authors: Seymour RL. PLoS Pathog. 2020 Feb 6;16(2):e1008102. doi: 10.1371/journal.ppat.1008102. eCollection 2020 Feb. PLoS Pathog. 2020. PMID: 32027727 Free PMC article.
Novel chikungunya vaccine candidate with an IRES-based attenuation and host range alteration mechanism.
Plante K, Wang E, Partidos CD, Weger J, Gorchakov R, Tsetsarkin K, Borland EM, Powers AM, Seymour R, Stinchcomb DT, Osorio JE, Frolov I, Weaver SC. Plante K, et al. PLoS Pathog. 2011 Jul;7(7):e1002142. doi: 10.1371/journal.ppat.1002142. Epub 2011 Jul 28. PLoS Pathog. 2011. PMID: 21829348 Free PMC article.
Vector-borne transmission imposes a severe bottleneck on an RNA virus population.
Forrester NL, Guerbois M, Seymour RL, Spratt H, Weaver SC. Forrester NL, et al. Among authors: Seymour RL. PLoS Pathog. 2012 Sep;8(9):e1002897. doi: 10.1371/journal.ppat.1002897. Epub 2012 Sep 13. PLoS Pathog. 2012. PMID: 23028310 Free PMC article.
Recombinant Isfahan Virus and Vesicular Stomatitis Virus Vaccine Vectors Provide Durable, Multivalent, Single-Dose Protection against Lethal Alphavirus Challenge.
Nasar F, Matassov D, Seymour RL, Latham T, Gorchakov RV, Nowak RM, Leal G, Hamm S, Eldridge JH, Tesh RB, Clarke DK, Weaver SC. Nasar F, et al. Among authors: Seymour RL. J Virol. 2017 Mar 29;91(8):e01729-16. doi: 10.1128/JVI.01729-16. Print 2017 Apr 15. J Virol. 2017. PMID: 28148802 Free PMC article.
Attenuation of Chikungunya virus vaccine strain 181/clone 25 is determined by two amino acid substitutions in the E2 envelope glycoprotein.
Gorchakov R, Wang E, Leal G, Forrester NL, Plante K, Rossi SL, Partidos CD, Adams AP, Seymour RL, Weger J, Borland EM, Sherman MB, Powers AM, Osorio JE, Weaver SC. Gorchakov R, et al. Among authors: Seymour RL. J Virol. 2012 Jun;86(11):6084-96. doi: 10.1128/JVI.06449-11. Epub 2012 Mar 28. J Virol. 2012. PMID: 22457519 Free PMC article.
Chikungunya vaccine candidate is highly attenuated and protects nonhuman primates against telemetrically monitored disease following a single dose.
Roy CJ, Adams AP, Wang E, Plante K, Gorchakov R, Seymour RL, Vinet-Oliphant H, Weaver SC. Roy CJ, et al. Among authors: Seymour RL. J Infect Dis. 2014 Jun 15;209(12):1891-9. doi: 10.1093/infdis/jiu014. Epub 2014 Jan 7. J Infect Dis. 2014. PMID: 24403555 Free PMC article.
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