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88 results
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Formation of cyclopropanone during cytochrome P450-catalyzed N-dealkylation of a cyclopropylamine.
Shaffer CL, Harriman S, Koen YM, Hanzlik RP. Shaffer CL, et al. J Am Chem Soc. 2002 Jul 17;124(28):8268-74. doi: 10.1021/ja0119346. J Am Chem Soc. 2002. PMID: 12105905
Enzymatic N-dealkylation of an N-cyclopropylamine: an unusual fate for the cyclopropyl group.
Shaffer CL, Morton MD, Hanzlik RP. Shaffer CL, et al. J Am Chem Soc. 2001 Jan 17;123(2):349-50. doi: 10.1021/ja003048l. J Am Chem Soc. 2001. PMID: 11456529 No abstract available.
N-dealkylation of an N-cyclopropylamine by horseradish peroxidase. Fate of the cyclopropyl group.
Shaffer CL, Morton MD, Hanzlik RP. Shaffer CL, et al. J Am Chem Soc. 2001 Sep 5;123(35):8502-8. doi: 10.1021/ja0111479. J Am Chem Soc. 2001. PMID: 11525657
Regulation of group I metabotropic glutamate receptor expression in the rat striatum and prefrontal cortex in response to amphetamine in vivo.
Shaffer C, Guo ML, Fibuch EE, Mao LM, Wang JQ. Shaffer C, et al. Brain Res. 2010 Apr 22;1326:184-92. doi: 10.1016/j.brainres.2010.02.062. Epub 2010 Feb 26. Brain Res. 2010. PMID: 20193665 Free PMC article.
Reversible palmitoylation regulates surface stability of AMPA receptors in the nucleus accumbens in response to cocaine in vivo.
Van Dolah DK, Mao LM, Shaffer C, Guo ML, Fibuch EE, Chu XP, Buch S, Wang JQ. Van Dolah DK, et al. Biol Psychiatry. 2011 Jun 1;69(11):1035-42. doi: 10.1016/j.biopsych.2010.11.025. Epub 2011 Jan 8. Biol Psychiatry. 2011. PMID: 21216391 Free PMC article.
Neurophysiological signals as potential translatable biomarkers for modulation of metabotropic glutamate 5 receptors.
Harvey BD, Siok CJ, Kiss T, Volfson D, Grimwood S, Shaffer CL, Hajós M. Harvey BD, et al. Among authors: shaffer cl. Neuropharmacology. 2013 Dec;75:19-30. doi: 10.1016/j.neuropharm.2013.06.020. Epub 2013 Jul 4. Neuropharmacology. 2013. PMID: 23831682
Mechanisms of Skin Toxicity Associated with Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators.
Shah F, Stepan AF, O'Mahony A, Velichko S, Folias AE, Houle C, Shaffer CL, Marcek J, Whritenour J, Stanton R, Berg EL. Shah F, et al. Among authors: shaffer cl. Cell Chem Biol. 2017 Jul 20;24(7):858-869.e5. doi: 10.1016/j.chembiol.2017.06.003. Epub 2017 Jun 29. Cell Chem Biol. 2017. PMID: 28669525
Prevention of ketamine-induced working memory impairments by AMPA potentiators in a nonhuman primate model of cognitive dysfunction.
Roberts BM, Holden DE, Shaffer CL, Seymour PA, Menniti FS, Schmidt CJ, Williams GV, Castner SA. Roberts BM, et al. Among authors: shaffer cl. Behav Brain Res. 2010 Sep 1;212(1):41-8. doi: 10.1016/j.bbr.2010.03.039. Epub 2010 Mar 27. Behav Brain Res. 2010. PMID: 20347881
A rational chemical intervention strategy to circumvent bioactivation liabilities associated with a nonpeptidyl thrombopoietin receptor agonist containing a 2-amino-4-arylthiazole motif.
Kalgutkar AS, Driscoll J, Zhao SX, Walker GS, Shepard RM, Soglia JR, Atherton J, Yu L, Mutlib AE, Munchhof MJ, Reiter LA, Jones CS, Doty JL, Trevena KA, Shaffer CL, Ripp SL. Kalgutkar AS, et al. Among authors: shaffer cl. Chem Res Toxicol. 2007 Dec;20(12):1954-65. doi: 10.1021/tx700270r. Epub 2007 Oct 13. Chem Res Toxicol. 2007. PMID: 17935300
Therapeutic doses of antidepressants are projected not to inhibit human α4β2 nicotinic acetylcholine receptors.
Weber ML, Hofland CM, Shaffer CL, Flik G, Cremers T, Hurst RS, Rollema H. Weber ML, et al. Among authors: shaffer cl. Neuropharmacology. 2013 Sep;72:88-95. doi: 10.1016/j.neuropharm.2013.04.027. Epub 2013 Apr 30. Neuropharmacology. 2013. PMID: 23639435
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