Shaffer CL - Search Results

1

A comprehensive listing of bioactivation pathways of organic functional groups.

Kalgutkar AS, Gardner I, Obach RS, Shaffer CL, Callegari E, Henne KR, Mutlib AE, Dalvie DK, Lee JS, Nakai Y, O'Donnell JP, Boer J, Harriman SP. Kalgutkar AS, et al. Among authors: shaffer cl. Curr Drug Metab. 2005 Jun;6(3):161-225. doi: 10.2174/1389200054021799. Curr Drug Metab. 2005. PMID: 15975040 Review.

2

Biotransformation of a GABAA receptor partial agonist in sprague-dawley rats and cynomolgus monkeys: identification of two unique N-carbamoyl metabolites.

Shaffer CL, Gunduz M, O'Connell TN, Obach RS, Yee S. Shaffer CL, et al. Drug Metab Dispos. 2005 Nov;33(11):1688-99. doi: 10.1124/dmd.105.004630. Epub 2005 Aug 4. Drug Metab Dispos. 2005. PMID: 16081672

3

A rational chemical intervention strategy to circumvent bioactivation liabilities associated with a nonpeptidyl thrombopoietin receptor agonist containing a 2-amino-4-arylthiazole motif.

Kalgutkar AS, Driscoll J, Zhao SX, Walker GS, Shepard RM, Soglia JR, Atherton J, Yu L, Mutlib AE, Munchhof MJ, Reiter LA, Jones CS, Doty JL, Trevena KA, Shaffer CL, Ripp SL. Kalgutkar AS, et al. Among authors: shaffer cl. Chem Res Toxicol. 2007 Dec;20(12):1954-65. doi: 10.1021/tx700270r. Epub 2007 Oct 13. Chem Res Toxicol. 2007. PMID: 17935300

4

Using Simcyp to project human oral pharmacokinetic variability in early drug research to mitigate mechanism-based adverse events.

Shaffer CL, Scialis RJ, Rong H, Obach RS. Shaffer CL, et al. Biopharm Drug Dispos. 2012 Mar;33(2):72-84. doi: 10.1002/bdd.1768. Epub 2012 Jan 17. Biopharm Drug Dispos. 2012. PMID: 22213407

5

Application of liquid chromatography-accelerator mass spectrometry (LC-AMS) to evaluate the metabolic profiles of a drug candidate in human urine and plasma.

Prakash C, Shaffer CL, Tremaine LM, Liberman RG, Skipper PL, Flarakos J, Tannenbaum SR. Prakash C, et al. Among authors: shaffer cl. Drug Metab Lett. 2007 Aug;1(3):226-31. doi: 10.2174/187231207781369735. Drug Metab Lett. 2007. PMID: 19356047

6

Formation of cyclopropanone during cytochrome P450-catalyzed N-dealkylation of a cyclopropylamine.

Shaffer CL, Harriman S, Koen YM, Hanzlik RP. Shaffer CL, et al. J Am Chem Soc. 2002 Jul 17;124(28):8268-74. doi: 10.1021/ja0119346. J Am Chem Soc. 2002. PMID: 12105905

7

Metabolism and disposition of a gamma-aminobutyric acid type A receptor partial agonist in humans.

Shaffer CL, Gunduz M, Vaz AD, Venkatakrishnan K, Burstein AH. Shaffer CL, et al. Drug Metab Dispos. 2008 Apr;36(4):655-62. doi: 10.1124/dmd.107.019760. Epub 2008 Jan 7. Drug Metab Dispos. 2008. PMID: 18180269

8

Metabolism and disposition of a selective alpha(7) nicotinic acetylcholine receptor agonist in humans.

Shaffer CL, Gunduz M, Scialis RJ, Fang AF. Shaffer CL, et al. Drug Metab Dispos. 2007 Jul;35(7):1188-95. doi: 10.1124/dmd.106.014449. Epub 2007 Apr 19. Drug Metab Dispos. 2007. PMID: 17446264 Clinical Trial.

9

Species differences in the biotransformation of an alpha 4 beta 2 nicotinic acetylcholine receptor partial agonist: the effects of distinct glucuronide metabolites on overall compound disposition.

Shaffer CL, Gunduz M, Ryder TF, O'Connell TN. Shaffer CL, et al. Drug Metab Dispos. 2010 Feb;38(2):292-301. doi: 10.1124/dmd.109.030171. Epub 2009 Nov 12. Drug Metab Dispos. 2010. PMID: 19910512

10

Using a tritiated compound to elucidate its preclinical metabolic and excretory pathways in vivo: exploring tritium exchange risk.

Shaffer CL, Gunduz M, Thornburgh BA, Fate GD. Shaffer CL, et al. Drug Metab Dispos. 2006 Sep;34(9):1615-23. doi: 10.1124/dmd.106.010934. Epub 2006 Jun 21. Drug Metab Dispos. 2006. PMID: 16790552

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