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GDNF/Ret signaling and the development of the kidney.
Costantini F, Shakya R. Costantini F, et al. Bioessays. 2006 Feb;28(2):117-27. doi: 10.1002/bies.20357. Bioessays. 2006. PMID: 16435290 Review.
Ret-dependent cell rearrangements in the Wolffian duct epithelium initiate ureteric bud morphogenesis.
Chi X, Michos O, Shakya R, Riccio P, Enomoto H, Licht JD, Asai N, Takahashi M, Ohgami N, Kato M, Mendelsohn C, Costantini F. Chi X, et al. Dev Cell. 2009 Aug;17(2):199-209. doi: 10.1016/j.devcel.2009.07.013. Dev Cell. 2009. PMID: 19686681 Free PMC article.
Branching morphogenesis of the ureteric epithelium during kidney development is coordinated by the opposing functions of GDNF and Sprouty1.
Basson MA, Watson-Johnson J, Shakya R, Akbulut S, Hyink D, Costantini FD, Wilson PD, Mason IJ, Licht JD. Basson MA, et al. Dev Biol. 2006 Nov 15;299(2):466-77. doi: 10.1016/j.ydbio.2006.08.051. Epub 2006 Aug 25. Dev Biol. 2006. PMID: 17022962
The role of GDNF in patterning the excretory system.
Shakya R, Jho EH, Kotka P, Wu Z, Kholodilov N, Burke R, D'Agati V, Costantini F. Shakya R, et al. Dev Biol. 2005 Jul 1;283(1):70-84. doi: 10.1016/j.ydbio.2005.04.008. Dev Biol. 2005. PMID: 15890330
Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction.
Basson MA, Akbulut S, Watson-Johnson J, Simon R, Carroll TJ, Shakya R, Gross I, Martin GR, Lufkin T, McMahon AP, Wilson PD, Costantini FD, Mason IJ, Licht JD. Basson MA, et al. Dev Cell. 2005 Feb;8(2):229-39. doi: 10.1016/j.devcel.2004.12.004. Dev Cell. 2005. PMID: 15691764
The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression.
Shakya R, Szabolcs M, McCarthy E, Ospina E, Basso K, Nandula S, Murty V, Baer R, Ludwig T. Shakya R, et al. Proc Natl Acad Sci U S A. 2008 May 13;105(19):7040-5. doi: 10.1073/pnas.0711032105. Epub 2008 Apr 28. Proc Natl Acad Sci U S A. 2008. PMID: 18443292 Free PMC article.
Stromal ETS2 Regulates Chemokine Production and Immune Cell Recruitment during Acinar-to-Ductal Metaplasia.
Pitarresi JR, Liu X, Sharma SM, CuitiƱo MC, Kladney RD, Mace TA, Donohue S, Nayak SG, Qu C, Lee J, Woelke SA, Trela S, LaPak K, Yu L, McElroy J, Rosol TJ, Shakya R, Ludwig T, Lesinski GB, Fernandez SA, Konieczny SF, Leone G, Wu J, Ostrowski MC. Pitarresi JR, et al. Neoplasia. 2016 Sep;18(9):541-52. doi: 10.1016/j.neo.2016.07.006. Neoplasia. 2016. PMID: 27659014 Free PMC article.
The transcriptional regulatory network of proneural glioma determines the genetic alterations selected during tumor progression.
Sonabend AM, Bansal M, Guarnieri P, Lei L, Amendolara B, Soderquist C, Leung R, Yun J, Kennedy B, Sisti J, Bruce S, Bruce R, Shakya R, Ludwig T, Rosenfeld S, Sims PA, Bruce JN, Califano A, Canoll P. Sonabend AM, et al. Cancer Res. 2014 Mar 1;74(5):1440-1451. doi: 10.1158/0008-5472.CAN-13-2150. Epub 2014 Jan 3. Cancer Res. 2014. PMID: 24390738 Free PMC article.
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