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Pharmacokinetics and pharmacodynamics of dichloroacetate in patients with cirrhosis.

Shangraw RE, Fisher DM. Shangraw RE, et al. Clin Pharmacol Ther. 1999 Oct;66(4):380-90. doi: 10.1053/cp.1999.v66.a101340. Clin Pharmacol Ther. 1999. PMID: 10546922

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Dichloroacetate stabilizes the intraoperative acid-base balance during liver transplantation.

Shangraw RE, Lohan-Mannion D, Hayes A, Moriarty RM, Fu R, Robinson ST. Shangraw RE, et al. Liver Transpl. 2008 Jul;14(7):989-98. doi: 10.1002/lt.21485. Liver Transpl. 2008. PMID: 18581513 Free article.

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Mechanism of dichloroacetate-induced hypolactatemia in humans with or without cirrhosis.

Shangraw RE, Jahoor F. Shangraw RE, et al. Metabolism. 2004 Aug;53(8):1087-94. doi: 10.1016/j.metabol.2004.02.020. Metabolism. 2004. PMID: 15281024 Clinical Trial.

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Metabolic issues in liver transplantation.

Shangraw RE. Shangraw RE. Int Anesthesiol Clin. 2006 Summer;44(3):1-20. doi: 10.1097/00004311-200604430-00003. Int Anesthesiol Clin. 2006. PMID: 16832203 Review. No abstract available.

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Lipolysis and lipid oxidation in cirrhosis and after liver transplantation.

Shangraw RE, Jahoor F. Shangraw RE, et al. Am J Physiol Gastrointest Liver Physiol. 2000 Jun;278(6):G967-73. doi: 10.1152/ajpgi.2000.278.6.G967. Am J Physiol Gastrointest Liver Physiol. 2000. PMID: 10859227 Free article.

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Effect of liver disease and transplantation on urea synthesis in humans: relationship to acid-base status.

Shangraw RE, Jahoor F. Shangraw RE, et al. Am J Physiol. 1999 May;276(5):G1145-52. doi: 10.1152/ajpgi.1999.276.5.G1145. Am J Physiol. 1999. PMID: 10330005

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Hepatic pyruvate dehydrogenase activity in humans: effect of cirrhosis, transplantation, and dichloroacetate.

Shangraw RE, Rabkin JM, Lopaschuk GD. Shangraw RE, et al. Am J Physiol. 1998 Mar;274(3):G569-77. doi: 10.1152/ajpgi.1998.274.3.G569. Am J Physiol. 1998. PMID: 9530159 Clinical Trial.

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Oxygen metabolism during liver transplantation: the effect of dichloroacetate.

Shangraw RE, Robinson ST. Shangraw RE, et al. Anesth Analg. 1997 Oct;85(4):746-52. doi: 10.1097/00000539-199710000-00007. Anesth Analg. 1997. PMID: 9322450 Clinical Trial.

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Pharmacokinetics of dichloroacetate in patients undergoing liver transplantation.

Shangraw RE, Fisher DM. Shangraw RE, et al. Anesthesiology. 1996 Apr;84(4):851-8. doi: 10.1097/00000542-199604000-00012. Anesthesiology. 1996. PMID: 8638839 Free article. Clinical Trial.

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Amelioration of lactic acidosis with dichloroacetate during liver transplantation in humans.

Shangraw RE, Winter R, Hromco J, Robinson ST, Gallaher EJ. Shangraw RE, et al. Anesthesiology. 1994 Nov;81(5):1127-38. doi: 10.1097/00000542-199411000-00006. Anesthesiology. 1994. PMID: 7978471 Free article. Clinical Trial.

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