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A systems study reveals concurrent activation of AMPK and mTOR by amino acids.
Dalle Pezze P, Ruf S, Sonntag AG, Langelaar-Makkinje M, Hall P, Heberle AM, Razquin Navas P, van Eunen K, Tölle RC, Schwarz JJ, Wiese H, Warscheid B, Deitersen J, Stork B, Fäßler E, Schäuble S, Hahn U, Horvatovich P, Shanley DP, Thedieck K. Dalle Pezze P, et al. Among authors: shanley dp. Nat Commun. 2016 Nov 21;7:13254. doi: 10.1038/ncomms13254. Nat Commun. 2016. PMID: 27869123 Free PMC article.
Modelling the checkpoint response to telomere uncapping in budding yeast.
Proctor CJ, Lydall DA, Boys RJ, Gillespie CS, Shanley DP, Wilkinson DJ, Kirkwood TB. Proctor CJ, et al. Among authors: shanley dp. J R Soc Interface. 2007 Feb 22;4(12):73-90. doi: 10.1098/rsif.2006.0148. J R Soc Interface. 2007. PMID: 17015293 Free PMC article.
Increasing extracellular H2O2 produces a bi-phasic response in intracellular H2O2, with peroxiredoxin hyperoxidation only triggered once the cellular H2O2-buffering capacity is overwhelmed.
Tomalin LE, Day AM, Underwood ZE, Smith GR, Dalle Pezze P, Rallis C, Patel W, Dickinson BC, Bähler J, Brewer TF, Chang CJ, Shanley DP, Veal EA. Tomalin LE, et al. Among authors: shanley dp. Free Radic Biol Med. 2016 Jun;95:333-48. doi: 10.1016/j.freeradbiomed.2016.02.035. Epub 2016 Mar 2. Free Radic Biol Med. 2016. PMID: 26944189 Free PMC article.
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