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Butein downregulates chemokine receptor CXCR4 expression and function through suppression of NF-κB activation in breast and pancreatic tumor cells.
Chua AW, Hay HS, Rajendran P, Shanmugam MK, Li F, Bist P, Koay ES, Lim LH, Kumar AP, Sethi G. Chua AW, et al. Biochem Pharmacol. 2010 Nov 15;80(10):1553-62. doi: 10.1016/j.bcp.2010.07.045. Epub 2010 Aug 10. Biochem Pharmacol. 2010. PMID: 20699088
Suppression of signal transducer and activator of transcription 3 activation by butein inhibits growth of human hepatocellular carcinoma in vivo.
Rajendran P, Ong TH, Chen L, Li F, Shanmugam MK, Vali S, Abbasi T, Kapoor S, Sharma A, Kumar AP, Hui KM, Sethi G. Rajendran P, et al. Clin Cancer Res. 2011 Mar 15;17(6):1425-39. doi: 10.1158/1078-0432.CCR-10-1123. Epub 2010 Dec 3. Clin Cancer Res. 2011. PMID: 21131551
γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent.
Rajendran P, Li F, Manu KA, Shanmugam MK, Loo SY, Kumar AP, Sethi G. Rajendran P, et al. Br J Pharmacol. 2011 May;163(2):283-98. doi: 10.1111/j.1476-5381.2010.01187.x. Br J Pharmacol. 2011. PMID: 21198544 Free PMC article.
Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice.
Shanmugam MK, Rajendran P, Li F, Nema T, Vali S, Abbasi T, Kapoor S, Sharma A, Kumar AP, Ho PC, Hui KM, Sethi G. Shanmugam MK, et al. J Mol Med (Berl). 2011 Jul;89(7):713-27. doi: 10.1007/s00109-011-0746-2. Epub 2011 Apr 5. J Mol Med (Berl). 2011. PMID: 21465181
Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate model.
Shanmugam MK, Manu KA, Ong TH, Ramachandran L, Surana R, Bist P, Lim LH, Kumar AP, Hui KM, Sethi G. Shanmugam MK, et al. Int J Cancer. 2011 Oct 1;129(7):1552-63. doi: 10.1002/ijc.26120. Epub 2011 Jul 20. Int J Cancer. 2011. PMID: 21480220
Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells.
Kannaiyan R, Hay HS, Rajendran P, Li F, Shanmugam MK, Vali S, Abbasi T, Kapoor S, Sharma A, Kumar AP, Chng WJ, Sethi G. Kannaiyan R, et al. Br J Pharmacol. 2011 Nov;164(5):1506-21. doi: 10.1111/j.1476-5381.2011.01449.x. Br J Pharmacol. 2011. PMID: 21506956 Free PMC article.
Honokiol inhibits signal transducer and activator of transcription-3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP-1.
Rajendran P, Li F, Shanmugam MK, Vali S, Abbasi T, Kapoor S, Ahn KS, Kumar AP, Sethi G. Rajendran P, et al. J Cell Physiol. 2012 May;227(5):2184-95. doi: 10.1002/jcp.22954. J Cell Physiol. 2012. PMID: 21792937
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